Non-invasive detection of aortic and coronary atherosclerosis in homozygous familial hypercholesterolemia by 64 slice multi-detector row computed tomography angiography

Santos, Raúl D.; Miname, Márcio H.; Martínez, Luis López; Rochitte, Carlos Eduardo; Chacra, Ana Paula Marte; Nakandakare, Edna Regina; Chen, David; Schaefer, Ernst J.

doi:10.1016/j.atherosclerosis.2007.08.017

Cited by 40 publications

(30 citation statements)

References 17 publications

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“…9 CTA detects the presence of CAD in both asymptomatic and symptomatic homozygous FH. 103,104 CTA can be used to detect aortic plaques affecting the coronary ostia and the coronary tree. Because extensive CAC may not be present in plaques in young subjects, CTA is preferable to simple noncontrast CT to detect CAC.…”

Section: Natural History Of Homozygous Fh and Subclinical Atherosclermentioning

confidence: 99%

The Agenda for Familial Hypercholesterolemia

Gidding¹,

Champagne²,

Ferranti³

et al. 2015

Circulation

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556

330

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Section: Natural History Of Homozygous Fh and Subclinical Atherosclermentioning

confidence: 99%

The Agenda for Familial Hypercholesterolemia

Gidding¹,

Champagne²,

Ferranti³

et al. 2015

Circulation

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556

330

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“…Indeed advanced subclinical atherosclerosis can be detected in FH patients cardiac computed tomography [79][80][81][82] Advanced subclinical atherosclerosis is defined as an elevated burden of subclinical atherosclerosis detected in the coronary arteries as shown in Table 1. …”

Section: Advanced Subclinical Coronary Atherosclerosis Burdenmentioning

confidence: 99%

Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel

Santos

Gidding

Hegele

et al. 2016

The Lancet Diabetes & Endocrinology

339

208

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Familial hypercholesterolaemia is common in individuals who had a myocardial infarction at a young age. As many as one in 200 people could have heterozygous familial hypercholesterolaemia, and up to one in 300 000 individuals could be homozygous. The phenotypes of heterozygous and homozygous familial hypercholesterolaemia overlap considerably; the response to treatment is also heterogeneous. In this Review, we aim to define a phenotype for severe familial hypercholesterolaemia and identify people at highest risk for cardiovascular disease, based on the concentration of LDL cholesterol in blood and individuals' responsiveness to conventional lipid-lowering treatment. We assess the importance of molecular characterisation and define the role of other cardiovascular risk factors and advanced subclinical coronary atherosclerosis in risk stratification. Individuals with severe familial hypercholesterolaemia might benefit in particular from early and more aggressive cholesterol-lowering treatment (eg, with PCSK9 inhibitors). In addition to better tailored therapy, more precise characterisation of individuals with severe familial hypercholesterolaemia could improve resource use

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“…Развитие ин-фаркта миокарда может встречаться уже на первом-втором десятилетии жизни (у «рецептор-дефект-ных» -на втором десятилетии жизни [3,6,11,12]. Атеросклеротическим процессом поражаются корень аорты, аортальный клапан, сосуды эластического типа [3,6,13,14]. Часто возникают дегенеративные изменения створок аортального клапана в связи с от-ложением липидов.…”

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“…Часто возникают дегенеративные изменения створок аортального клапана в связи с от-ложением липидов. Типичен систолический шум из-гнания над аортальным клапаном за счет над-и/или клапанного аортального стеноза [13][14][15]. Отложение холестерина на створках аортального клапана мо-жет также приводить к аортальной недостаточности [3,14].…”

unclassified

“…Для ранней диагностики субклинических форм коронарного атеросклероза должна использо-ваться компъютерная коронарная ангиография или магнитно-резонансная томография с частотой 1 раз в 5 лет. Поражение аортального клапана устанавлива-ется при проведении допплерэхокардиографии и ве-рифицируется результатами транспищеводной эхо-кардиографии [14,15].…”

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Modern Approaches to the Treatment of Homozygous Familial Hypercholesterolemia

Леонтьева¹

2017

Ross. vestn. perinatol. pediatr.

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Non-invasive detection of aortic and coronary atherosclerosis in homozygous familial hypercholesterolemia by 64 slice multi-detector row computed tomography angiography

Cited by 40 publications

References 17 publications

The Agenda for Familial Hypercholesterolemia

The Agenda for Familial Hypercholesterolemia

Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel

Modern Approaches to the Treatment of Homozygous Familial Hypercholesterolemia

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