Non-invasive characterization of stationary phases in capillary flow systems using scanning capacitively coupled contactless conductivity detection (sC4D)

Connolly, Damian; Floris, Patrick; Paull, Brett; Nesterenko, Pavel N.

doi:10.1016/j.trac.2010.04.007

Cited by 30 publications

(21 citation statements)

References 48 publications

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“…Contactless conductivity scanning also represents an easy tool for characterizing PLOT-column homogeneity, as the conductivity of bulk solution corresponds to the layer thickness [56][57][58]. Confocal scanning microscopy [59] and X-ray scanning also represent non-destructive options, but at much higher costs at this stage [60].…”

Section: Resultsmentioning

confidence: 99%

Surface-area expansion with monolithic open tubular columns

Knob

Kulsing

Boysen

et al. 2015

TrAC Trends in Analytical Chemistry

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Section: Resultsmentioning

confidence: 99%

Surface-area expansion with monolithic open tubular columns

Knob

Kulsing

Boysen

et al. 2015

TrAC Trends in Analytical Chemistry

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“…Contactless conductivity detection has been proven to be a very versatile detection method, frequently used in electrophoresis [21] ion chromatography and nonintrusive inspection of monolithic columns [22]. This technique typically utilizes two electrodes separated from the electrolyte by an insulating layer in which the excitation voltage is applied to the cell actuating electrode (S1) and the current from the sensing electrode is directed to the measurement electronics, see Figure 3.…”

Section: System Descriptionmentioning

confidence: 99%

Design and Test Issues for Lab-on-Chip Ion Separation for In-Situ Water Quality Monitoring

Joly

Bell

Fallatah

et al. 2012

2012 IEEE 18th International Mixed-Signal, Sensors, and Systems Test Workshop

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Recently there have been advances in automatic monitoring systems for water quality linked to environmental modeling. The difficulty of performing such sensing in natural environments leads to a high probability of faults and demands for high density data make automated self-test an important requirement. As part of an evaluation of failures in Lab-onChip (LOC) Ion Chromatography (IC) and Capillary Electrophoresis (CE) based systems, we passed river water through LOC devices for long periods showing that such system are feasible, but illustrating that failures are likely. Conductivity is the preferred method of detection for IC and CE, but a problem with all such detectors is the need to suppress background conductivity. Chemical suppression is often utilized, but in-situ systems can be simplified using electronic methods. We have developed an approach which directly suppresses baseline current. Detection signals and baseline profiles can be used to diagnose faults, typically manually by an experienced technician. In this paper we discuss automated test strategies for in-situ monitors at both the sensor network and individual instrument level. We also report preliminary investigations into development of automated fault detection using baseline and detection signals.

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“…Currivan et al prepared capillary monolithic columns with a gradient of IDA ligand along the column length 68 and the gradient ligand coverage was studied by scanning capacitively coupled contactless conductivity detection (sC 4 D) 69. Although the application of these novel monolithic columns has not been demonstrated, it is important to mention that the characterization technique used in this work could be a useful non‐invasive method to gain information on the longitudinal homogeneity of capillary columns used in IMAC.…”

Section: Special Applications Of Monolithic Columns In Acmentioning

confidence: 99%

Macroporous monolithic supports for affinity chromatography

Arrua

Igarzabal

2011

J of Separation Science

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In the early 1990s, three research groups simultaneously developed continuous macroporous rod-shaped polymeric systems to eliminate the problem of flow through the interparticle spaces generally presented by the chromatography columns that use particles as filler. The great advantage of those materials, forming a continuous phase rod, is to increase the mass transfer by convective transport, as the mobile phase is forced to go through all means of separation, in contrast to particulate media where the mobile phase flows through the interparticle spaces. Due to their special characteristics, the monolithic polymers are used as base-supports in different separation techniques, those chromatographic processes being the most important and, to a greater extent, those involving the separation of biomolecules as in the case of affinity chromatography. This mini-review reports the contributions of several groups to the development of macroporous monoliths and their modification by immobilization of specific ligands on the products for their application in affinity chromatography.

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Non-invasive characterization of stationary phases in capillary flow systems using scanning capacitively coupled contactless conductivity detection (sC4D)

Cited by 30 publications

References 48 publications

Surface-area expansion with monolithic open tubular columns

Surface-area expansion with monolithic open tubular columns

Design and Test Issues for Lab-on-Chip Ion Separation for In-Situ Water Quality Monitoring

Macroporous monolithic supports for affinity chromatography

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