Non-invasive assessment of hepatic fibrosis in a series of patients with Wilson's Disease

Sini, Margherita; Sorbello, Orazio; Civolani, Alberto; Liggi, Mauro; Demelia, Luigi

doi:10.1016/j.dld.2011.12.010

Cited by 41 publications

(23 citation statements)

References 17 publications

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“…However, current liver biopsies were not justifiable in the clinically stable population. Comparison between noninvasively estimated and biopsy-proven fibrosis has only been performed in one small monocentric Wilson's population so far [26]. This cohort included only two cirrhotic patients, and described a TE cutoff value of 8.4 kPa for the detection of cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores

Karlas

Hempel

Tröltzsch

et al. 2012

Scandinavian Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 99%

Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores

Karlas

Hempel

Tröltzsch

et al. 2012

Scandinavian Journal of Gastroenterology

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“…In particular, repeated examinations on serial follow-up, especially in infants and children, are nearly impossible. In contrast, TE, a physical (ultrasonographic) method for evaluating fibrosis, is simple and noninvasive (10) and has been analyzed in many adults and some pediatric studies (2,3,11,12). Because of its noninvasiveness, TE has already been widely used in children, despite a lack of clinical data.…”

Section: Discussionmentioning

confidence: 99%

Points to Be Considered When Applying FibroScan S Probe in Children With Biliary Atresia

Kim¹,

Kang²,

Lee³

et al. 2014

J. pediatr. gastroenterol. nutr.

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Objectives:With the introduction of smaller probes (S1, S2), the use of transient elastography has been expanded to children. Accordingly, we aimed to address points of consideration in probe choice and interpretation of measured liver stiffness by applying and comparing FibroScan S and M probes in biliary atresia.Methods:Using S1, S2, and M probes, 3 liver stiffness measurements, success rates, and interquartile ranges were obtained from 100 patients. Patients were assigned to 2 groups according to thoracic perimeter (≤45 cm vs >45 cm). In both groups, obtained values were compared and the relation between liver stiffness measurement and aspartate aminotransferase-to-platelet ratio index was analyzed.Results:In the small-thorax group, the success rate was highest with the S1 probe and the intraclass correlation coefficient (ICC) was highest for S1 versus S2 (0.98), compared with that for S1 versus M (0.69) and S2 versus M (0.77). In the large-thorax group, ICC was the highest for S2 versus M (0.88), compared with that for S1 versus S2 (0.69) and S1 versus M (0.51). In the small-thorax group, correlations between aspartate aminotransferase-to-platelet ratio index and liver stiffness measurement were stronger for S1 (0.65) and S2 (0.64) than for M (0.49). In the large-thorax group, all probes showed good correlation, S1 (0.68), S2 (0.62), and M (0.62).Conclusions:We recommend that the S1 probe is more appropriate for use in small children, especially those with a thorax perimeter of <45 cm. If no S probe is available, the M probe may be acceptable in children whose thorax perimeter is >45 cm.

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“…TE uses the propagation velocity of a pressure‐induced shear wave to calculate liver stiffness. Its results have been shown to correlate well with fibrosis score on liver histology in various liver diseases in adults . The technique is generally applicable in children and has been shown to be of some diagnostic value in children with biliary atresia, cystic fibrosis, autoimmune liver disease, and NASH/NAFLD .…”

mentioning

confidence: 85%

The use of transient elastography and non‐invasive serum markers of fibrosis in pediatric liver transplant recipients

Goldschmidt

Stieghorst

Munteanu

et al. 2013

Pediatric Transplantation

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The use of non-invasive markers to diagnose liver allograft fibrosis is not well established in children after LTx. TE, FT, and ELF score were performed in 117 liver-transplanted children (60M, 8.9 [0.5-18.5] yr) and 336 healthy controls. Liver biopsy was available in 36 children. Results of histology and non-invasive markers were compared using correlation coefficient or Mann-Whitney U-test as appropriate. TE correlated best with histological degree of fibrosis (r = 0.85 vs. r = 0.04 [FT] or r = -0.38 [ELF]). Liver stiffness values for transplanted children without fibrosis were significantly higher than those of healthy controls (7.55 [5.4-20.4] kPa vs. 4.5 [2.5-8.9] kPa). Presence of rejection was a potent confounder for the performance of TE. Both TE and FT reflected clinical changes (acute rejection, cholestasis, increasing fibrosis) in a total of 16 patients who underwent serial measurements. TE correlates better with histological degree of fibrosis in liver-transplanted children than FT or ELF, but an individual baseline value needs to be determined for each patient. Normal or cutoff values for pathological degrees of fibrosis cannot be transferred from non-transplanted children. Follow-up studies, preferably with protocol biopsies, might help to improve the diagnostic quality of TE.

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Non-invasive assessment of hepatic fibrosis in a series of patients with Wilson's Disease

Cited by 41 publications

References 17 publications

Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores

Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores

Points to Be Considered When Applying FibroScan S Probe in Children With Biliary Atresia

The use of transient elastography and non‐invasive serum markers of fibrosis in pediatric liver transplant recipients

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