Points to Be Considered When Applying FibroScan S Probe in Children With Biliary Atresia

Kim, Seung; Kang, Yunkoo; Lee, Mi Jung; Kim, Myung Joon; Han, Seok Joo; Koh, Hong

doi:10.1097/mpg.0000000000000489

Cited by 22 publications

(28 citation statements)

References 18 publications

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“…Recently, 2D-SWE accuracy was evaluated in children post liver transplantation [21]. Other studies analyzed the influence of some technical parameters on measurement reliability such as: type of probe used, place and depth of measurement [15,22]. Tutar et al [23] showed that although liver fibrosis can be assessed using 2D-SWE in children, differentiation of mild to moderate fibrosis stages (F1, F2) could not be achieved.…”

Section: Discussionmentioning

confidence: 99%

“…The paediatric S probes can improve reliability in this regard. A recent study [22] aimed at addressing points of consideration in the probe choice and interpretation of measured LS by comparing FibroScan S1, S2 and M probes in children with biliary atresia. The authors concluded that the S1 probe is more appropriate for use in small children, especially those with a thorax perimeter of <45 cm, but if no S probe is available, the M probe may be acceptable in children whose thorax perimeter is >45 cm [22].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of three ultrasound based elastographic techniques in children and adolescents with chronic diffuse liver diseases.

et al. 2016

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Non-invasive techniques for liver fibrosis assessment were developed for adults and recent researches tested their accuracy in children. The only validated elastographic method for non-invasive liver fibrosis evaluation in children is Transient Elastography (TE). The aim of our study was to investigate the feasibility of liver stiffness (LS) measurement in paediatric patients with chronic liver diseases by means of Acoustic Radiation Force Impulse Elastography (ARFI) and 2D-Shear Wave Elastography (2D-SWE), compared to TE as reference method. Material and methods: We enrolled 54 consecutive children and adolescents with different chronic liver diseases. All patients were examined by means of TE, ARFI, and 2D-SWE. All measurements were performed in the right liver lobe, in the same session, in fasting condition. We considered reliable LS elastographic measurements as follows: for TE and ARFI -the median value of ten measurements with a success rate≥60% and an interquartile range<30%, for 2D-SWE -the median value of five measurements. Results: The successful measurement rate for TE was 94.4% (51/54). Taking TE as a reference method, sensitivity of ARFI for detecting fibrosis F1 was 71.42%, for F2-77.77%, for F3-62.5% and for F4-71.42%. Sensitivity of 2D-SWE for detecting F1 was 92.85%, for F2-83.33%, for F3-87.5% and for F4-85.71%. We found significant correlations between TE and 2D-SWE on the entire lot (Kappa correlation factor=0.843, p=0.001). Analyzing the subgroup with SR=60%-70%, we did not find significant correlation between TE and ARFI (Kappa correlation factor=0.172, p=0.452). Assessing the subgroup with SR>70%, we found a significant correlation between TE and ARFI (Kappa correlation factor=0.761, p=0.001). Conclusions: Overall, 2D-SWE correlate better with TE compared to ARFI in children. Excluding patients with less satisfactory technical parameters, we obtained significant correlations between all three methods. Both SWE and ARFI are non-invasive techniques feasible of performing on paediatric patients along with TE.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of three ultrasound based elastographic techniques in children and adolescents with chronic diffuse liver diseases.

et al. 2016

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“…The S probes (S1 and S2) use a pulse-tracking frequency of 5 MHz at window depths of 15–40 mm and 20–50 mm, respectively [21]. The M probe uses a pulse-tracking frequency of 3.5 MHz at a window depth of 20–60 mm, and the XL probe uses a lower pulse-tracking frequency of 2.5 MHz at a window depth of 35–75 mm [19, 22].…”

Section: Ultrasound-based Dynamic Elastographymentioning

confidence: 99%

Ultrasound Elastography and MR Elastography for Assessing Liver Fibrosis: Part 1, Principles and Techniques

Tang

Cloutier

Szeverenyi

et al. 2015

American Journal of Roentgenology

172

141

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OBJECTIVE The purpose of this article is to provide an overview of ultrasound and MR elastography, including a glossary of relevant terminology, a classification of elastography techniques, and a discussion of their respective strengths and limitations. CONCLUSION Elastography is an emerging technique for the noninvasive assessment of mechanical tissue properties. These techniques report metrics related to tissue stiffness, such as shear-wave speed, magnitude of the complex shear modulus, and the Young modulus.

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“…It has been shown that LSM decreased with probe size (S1 < S2 < M) and caution is needed when interpreting the results [52].…”

Section: Te In Healthy Childrenmentioning

confidence: 99%

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

et al. 2018

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Featured Application: In this review we present and discuss the published literature on the use of ultrasound-based liver elastography in children. The published data show that all the available shear wave elastography techniques are feasible and accurate for the assessment of liver fibrosis in children with diffuse liver disease due to several etiologies. For the assessment of focal liver lesions evidences are limited and no conclusion can be drawn so far.Abstract: Studies performed using transient elastography (TE), point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) have shown that these techniques are all feasible and accurate in children for the evaluation of liver fibrosis due to several etiologies. However, for some specific pediatric pathologies, such as biliary atresia, the evidence is still limited. As shown in adults, inflammation is a confounding factor when assessing fibrosis severity and care should be taken when interpreting the results. Due to the scarce comparative data between serological tests and elastography techniques in children, a definite conclusion regarding which is the best cannot be drawn. Neither non-invasive elastographic techniques nor laboratory scores allow determination of the presence and the degree of inflammation, necrosis, iron or copper deposits.

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Points to Be Considered When Applying FibroScan S Probe in Children With Biliary Atresia

Cited by 22 publications

References 18 publications

Comparison of three ultrasound based elastographic techniques in children and adolescents with chronic diffuse liver diseases.

Comparison of three ultrasound based elastographic techniques in children and adolescents with chronic diffuse liver diseases.

Ultrasound Elastography and MR Elastography for Assessing Liver Fibrosis: Part 1, Principles and Techniques

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

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