Non-Helicobacter pylori Helicobacter Infections in Humans and Animals

Flahou, Bram; Haesebrouck, Freddy; Smet, Annemieke

doi:10.1007/978-4-431-55936-8_10

Cited by 16 publications

(30 citation statements)

References 240 publications

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“…3). These two latter species are also the most prevalent species in cats and dogs, respectively [16,17]. Furthermore, our admixture analysis based on the BAPS population assignment indicated that the singleton pet-associated strains canine H. cynogastricus and feline H. baculiformis are hybrids, in that they have received a considerable amount of DNA from H. felis (Fig.…”

Section: Discussionmentioning

confidence: 72%

“…The Helicobacter genus currently comprises 46 Gramnegative species that have established symbiotic relationships in the gastrointestinal tract of one or more hosts; several of these are of pathogenic importance both to humans and animals [17]. This work aimed to elucidate a scenario of Helicobacter evolution and, in particular, the natural history of gastric Helicobacter species based on comparative genomics encompassing the species known to date.…”

Section: Discussionmentioning

confidence: 99%

“…A distinct feature is their association with mucosa-associated lymphoid tissue (MALT) lymphoma, another type of gastric cancer that is less prevalent in humans [14,16]. Not all NHPH colonize the pets and pigs, for example H. suncus colonizes the stomach of house musk shrews [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence

et al. 2018

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Since the discovery of the human pathogen Helicobacter pylori, various other Helicobacter species have been identified in the stomach of domesticated and wild mammals. To better understand the evolutionary history of these ecologically similar but genetically distinct species, we analyzed 108 gastric Helicobacter genomes and included 54 enterohepatic Helicobacter genomes for comparison purposes. An admixture analysis supported the presence of an ecological barrier, preventing the genetic exchange between the gastric and enterohepatic Helicobacter species, and unraveled many gene flow events within and across species residing in the stomach. As pets can be colonized by multiple gastric Helicobacter species, the genetic exchange between the canine and feline strains was evident, with H. heilmannii and H. bizzozeronii showing the highest interspecies recombination. An admixture between H. pylori (in particular, the ancestral African strains), H. acinonychis from wild felines and H. cetorum from marine mammals was also identified. Because these latter species do not share the same host, this phenomenon is most likely a remaining signal of shared ancestry. A reconstruction of the time of divergence of the gastric Helicobacter spp. revealed that the domestic animal-related Helicobacter species evolved in parallel with H. pylori and its two closest relatives (H. acinonychis and H. cetorum), rather than together.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence

et al. 2018

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“…GH are able to colonize the gastric mucosa by expressing urease to overcome the acidic environment in the stomach, while EHH colonize the intestinal mucosa and/or the liver . EHH have become increasingly important over recent years as emerging pathogens and potential zoonotic agents associated with hepatobiliary, pancreatic, and bowel diseases in humans . However, the traditional culture methods used in clinical laboratories are generally unable to detect them and consequently their clinical significance is underestimated …”

Section: Introductionmentioning

confidence: 99%

“…4 EHH have become increasingly important over recent years as emerging pathogens and potential zoonotic agents associated with hepatobiliary, pancreatic, and bowel diseases in humans. 5 However, the traditional culture methods used in clinical laboratories are generally unable to detect them and consequently their clinical significance is underestimated. 6,7 In 2014, we described the species Helicobacter valdiviensis, a novel EHH isolated from wild bird fecal samples in the south of Chile (South America), 8 and since then other putative new non-H. pylori species have been isolated from several wild animals.…”

Section: Introductionmentioning

confidence: 99%

Genomic and clinical evidence uncovers the enterohepatic species Helicobacter valdiviensis as a potential human intestinal pathogen

et al. 2017

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Horizontal gene transfer has contributed to shape the gene repertory of H. valdiviensis, which codes for virulence factors conserved in other pathogens that are well-known human pathogens. Additionally, the detection of H. valdiviensisDNA in diarrheic patients supports its role as a potential emergent intestinal pathogen. Further, sampling efforts are needed to uncover the clinical relevance of this species, which should be accomplished by the isolation of H. valdiviensis from ill humans and the obtention of whole genomes from clinical isolates.

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In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species

Bauwens

Joosten

Taganna

et al. 2018

Sci Rep

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Helicobacter (H.) pylori is an important risk factor for gastric malignancies worldwide. Its outer membrane proteome takes an important role in colonization of the human gastric mucosa. However, in zoonotic non-H. pylori helicobacters (NHPHs) also associated with human gastric disease, the composition of the outer membrane (OM) proteome and its relative contribution to disease remain largely unknown. By means of a comprehensive survey of the diversity and distribution of predicted outer membrane proteins (OMPs) identified in all known gastric Helicobacter species with fully annotated genome sequences, we found genus- and species-specific families known or thought to be implicated in virulence. Hop adhesins, part of the Helicobacter-specific family 13 (Hop, Hor and Hom) were restricted to the gastric species H. pylori, H. cetorum and H. acinonychis. Hof proteins (family 33) were putative adhesins with predicted Occ- or MOMP-family like 18-stranded β-barrels. They were found to be widespread amongst all gastric Helicobacter species only sporadically detected in enterohepatic Helicobacter species. These latter are other members within the genus Helicobacter, although ecologically and genetically distinct. LpxR, a lipopolysaccharide remodeling factor, was also detected in all gastric Helicobacter species but lacking as well from the enterohepatic species H. cinaedi, H. equorum and H. hepaticus. In conclusion, our systemic survey of Helicobacter OMPs points to species and infection-site specific members that are interesting candidates for future virulence and colonization studies.

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Non-Helicobacter pylori Helicobacter Infections in Humans and Animals

Cited by 16 publications

References 240 publications

Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence

Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence

Genomic and clinical evidence uncovers the enterohepatic species Helicobacter valdiviensis as a potential human intestinal pathogen

In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species

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