Non-HDL-C vs. LDL-C in Predicting the Severity of Coronary Atherosclerosis

Roever, Leonardo; Biondi‐Zoccai, Giuseppe; Chagas, Antônio Carlos Palandri

doi:10.1016/j.hlc.2016.06.790

Cited by 21 publications

(19 citation statements)

References 26 publications

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“…LDL-C content of the mice was clearly an independent risk factor for atherosclerosis [ 29 ] and the rate of LDL-C/HDL-C (Atherosclerosis-index, AI) was a more relevant risk indicator in lipid metabolism disorders [ 30 ]. Different diets affected AI with KO diet had better AI than lard based high fat diet, which followed the order: HF diets (0.20) > KO diets (0.15) > NC diets (0.04).…”

Section: Resultsmentioning

confidence: 99%

Effects of Antarctic krill oil on lipid and glucose metabolism in C57BL/6J mice fed with high fat diet

et al. 2017

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BackgroundObesity and other metabolic diseases have become epidemic which greatly affect human health. Diets with healthy nutrition are efficient means to prevent this epidemic occurrence. Novel food resources and process technology were needed for these purpose. In this study, Antarctic krill oil (KO) extracted from a dry krill by a procedure of hot pump dehydration in combined with freezing-drying was used to investigate health effect in animals including the growth, lipid and glucose metabolism.MethodsC57BL/6J mice were fed with a lard based high fat (HF) diet and substituted with KO for a period of 12 weeks in comparison with low fat normal control (NC) diet. Mice body weight and food consumption were recorded. Serum lipid metabolism - of C57BL/6J mice serum was measured. A glucose tolerance tests (GTTs) and pathology analysis of mice were performed at the end of the experiment.ResultsThe KO fed mice had less body weight gain, less fat accumulation in tissue such as adipose and liver. Dyslipidemia induced by high fat diet was partially improved by KO feeding with significant reduction of serum low density lipoprotein-cholesterol (LDL-C) content. Furthermore, KO feeding also improved glucose metabolism in C57BL/6J mice including a glucose tolerance of about 22% vs. 32% of AUC (area under the curve) for KO vs HF diet and the fast blood glucose level of 8.5 mmol/L, 9.8 mmol/L and 9.3 mmol/L for NC, HF and KO diet groups, respectively. In addition, KO feeding also reduced oxidative damage in liver with a decrease of malondialdehyde (MDA) content and increase of superoxide dismutase (SOD) content.ConclusionThis study provided evidence of the beneficial effects of KO on animal health from the processed technology, particularly on lipid and glucose metabolism. This study confirmed that as the Antarctic krill was extracted with a procedure of efficient energy, it might make it possible for Krill oil to be available for food industry.

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Section: Resultsmentioning

confidence: 99%

Effects of Antarctic krill oil on lipid and glucose metabolism in C57BL/6J mice fed with high fat diet

et al. 2017

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“…In addition, non-HDL-c and HDL-c can predict the severity of coronary artery lesions. Non-HDL-c indicates a total of cholesterol within all the apolipoprotein B (Apo B) particle including LDL-c and remnant cholesterol [20]. From a prospective study of CGPS, the remnant cholesterol, composed of VLDL-c and intermediate-density lipoproteins (IDL-c), is also a causal risk factor for ischemic heart disease (IHD) [21].…”

Section: Discussionmentioning

confidence: 99%

Non-HDL-c/TC: A Novel Lipid-Related Marker in the Assessment of Severity of Coronary Artery Lesions and Cardiovascular Outcomes

Huang

Wei

et al. 2019

Cardiology Research and Practice

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Background. Non-high-density lipoprotein cholesterol (non-HDL-c) predicts the severity of coronary artery lesions in patients not treated with statin. The association between non-HDL-c and severity of coronary artery lesions in patients treated with lipid-lowering therapy has been unknown. Hypothesis. We hypothesize a novel marker of non-HDL-c/TC predicts the severity of coronary artery lesions and clinical outcomes in 12 months in the patients treated with statin. Method. 473 subjects who met inclusion criteria were eligible for inclusion. Coronary artery angiography (CAG) was performed, and the Gensini score (GS) was calculated in all the subjects divided into three subgroups of low risk, medium risk, and high risk by the tertiles of GS. The non-HDL-c value was calculated as TC minus HDL-c, while non-HDL-c/TC was the ratio of non-HDL-c and TC. Results. The concentration of non-LDL-c differed between non-obstructive-CAD group and obstructive-CAD group (P<0.05), and non-HDL-c/TC was elevated in the obstructive-CAD group (P<0.05). Increased GS was associated with increasing non-HDL-c/TC (P<0.05). Non-HDL-c/TC (OR: 108.50, 95% CI: 1.57–7520.28; P=0.030) remained as an independent predicting factor of high risk under GS stratification. In unadjusted Cox model, high non-HDL-c/TC (RR: 1.976, 95% CI: 1.155–3.382; P=0.013) predicted the occurrence of adverse events. After multivariate adjustment, high non-HDL-c/TC (RR: 1.921, 95% CI: 1.105–3.339; P=0.021) was an independent predictor of poor outcomes. Conclusion. High level of non-HDL-c/TC presented an excellent prognostic value compared with other lipid-related markers in CAD patients treated with statin.

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“…Warto zauważyć, że lipidogram zazwyczaj rozpoczyna się od podania wartości TC, choć obecnie ma to przede wszystkim wartość historyczną, a sam wynik służy jako: -bardzo wstępne określenie natężenia tego czynnika ryzyka; -substrat do działania matematycznego (wyliczenia wartości nie-HDL-C); -określenie ryzyka w skali SCORE (Systematic COronary Risk Evaluation), w której stężenie TC jest potrzebne na równi z wartością ciśnienia skurczowego, informacją o nałogu palenia tytoniu, wiekiem i płcią pacjenta do oszacowania jego ryzyka sercowo-naczyniowego w prewencji pierwotnej. Dlatego w lipidogramie nadal powinny się znaleźć stężenia: -TC; -LDL-C; wyniku lipidogramu, który mógłby wyglądać jak na rycinie 3 i spełniać omówione zmiany celów i hierarchii wartości poszczególnych frakcji lipidowych [19].…”

Section: Podsumowanieunclassified

Czy nie-HDL cholesterol lepiej niż cholesterol frakcji LDL odzwierciedla ryzyko sercowo-naczyniowe?

2018

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Non-HDL-C vs. LDL-C in Predicting the Severity of Coronary Atherosclerosis

Cited by 21 publications

References 26 publications

Effects of Antarctic krill oil on lipid and glucose metabolism in C57BL/6J mice fed with high fat diet

Effects of Antarctic krill oil on lipid and glucose metabolism in C57BL/6J mice fed with high fat diet

Non-HDL-c/TC: A Novel Lipid-Related Marker in the Assessment of Severity of Coronary Artery Lesions and Cardiovascular Outcomes

Czy nie-HDL cholesterol lepiej niż cholesterol frakcji LDL odzwierciedla ryzyko sercowo-naczyniowe?

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