Czy nie-HDL cholesterol lepiej niż cholesterol frakcji LDL odzwierciedla ryzyko sercowo-naczyniowe?

2021 PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on the diagnosis and therapy of lipid disorders in Poland

“…This is of particular diagnostic importance if the accuracy of the LDL-C concentration calculation is limited. According to numerous studies, non-HDL-C concentration is more predictive for cardiovascular risk than LDL-C concentration [87,88]. Non-HDL-C concentration is calculated using the following formula: Non-HDL-C = TC -HDL-C (in mmol/l or mg/dl)…”

2020 Guidelines of the Polish Society of Laboratory Diagnostics (PSLD) and the Polish Lipid Association (PoLA) on laboratory diagnostics of lipid metabolism disorders

“…It should be a permanent element of the lipid profile as it represents the concentration of all atherogenic lipoprotein fractions. The available studies show that it is more predictive in CV risk assessment than LDL-C [44,45].…”

“…Non-HDL-C calculation is more reliable than the calculation of LDL-C [45,46]. As with other formulas, the accuracy of non-HDL-C calculation depends on the biological and analytical variability of the TC and HDL-C levels.…”

2024 Guidelines of the Polish Society of Laboratory Diagnostics and the Polish Lipid Association on laboratory diagnostics of lipid metabolism disorders.

“…These include the apoB-containing particles LDL, VLDL, IDL, CM, TRL remnants and Lp(a). Determination of non-HDL-C level is very important for cardiovascular risk assessment and, as of 2021 (Guidelines of PoLA and five other scientific societies [ 5 ]), is recommended as a permanent element of the lipid profile because it complements LDL-C by allowing the assessment of residual risk and, based on available studies, is more predictive of cardiovascular risk than LDL-C levels and most often equally predictive as apoB measurement reflecting the number of atherogenic lipoprotein particles [ 65 , 66 ]. Non-HDL-cholesterol is now also a recommended parameter in the assessment of cardiovascular risk in SCORE2 and SCORE2-OP and, according to recent Polish recommendations, is the basis for the diagnosis of metabolic syndrome [ 67 ].…”

“…The calculation of non-HDL-C is more reliable than the calculation of LDL-C [ 66 , 68 ]. Nevertheless, as with the use of other formulas, the accuracy of non-HDL-C calculation depends on the biological and analytical variability of TC and HDL-C concentrations.…”