Interpretation: Higher resting heart rate was independently associated with increased risks of all-cause and cardiovascular mortality. This indicates that resting heart rate is a predictor of all-cause and cardiovascular mortality in the general population. Abstract Research E54CMAJ, February 16, 2016, 188(3) traditional risk factors of cardiovascular disease on the association of resting heart rate with risk of all-cause and cardiovascular mortality. Methods Literature search and selectionWe searched PubMed, Embase and MEDLINE from inception to Jan. 1, 2015, restricting the search to studies involving humans and published in English or Chinese. Details of the search strategy are shown in Appendix 1 (available at www.cmaj.ca/lookup/suppl/doi:10.1503/ cmaj.150535/-/DC1). We reviewed the reference lists from retrieved articles to search for further relevant studies. Studies were included if they met the following criteria: the study group was the general population (i.e., excluding studies in disease-specific populations); the exposure of interest was resting heart rate; the outcome of interest was all-cause or cardiovascular mortality; age-or multivariateadjusted relative risk estimates with 95% confidence intervals (CIs) were provided; and the study used a prospective design. If data were duplicated in more than 1 study, we included the study with the longest follow-up duration. Two investigators (D.Z. and X.S) independently conducted the literature search and selection.

New 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivatives (1 and 2) were synthesized as an "off-on" fluorescent chemosensor and fluorescent chemodosimeter for Cu2+ and Pb2+. Compound 1 displayed selective and large chelation enhanced fluorescence effects with Pb2+ and Cu2+ among the metal ions examined. On the other hand, compound 2, a fluorescent chemodosimeter, effectively recognized Cu2+ via a selective hydrolysis of the acetyl group.

A layer of SiO was deposited on the surface of poly(L-lactic acid) (PLLA) film to fabricate a PLLA/SiO layered film, by plasma-enhanced chemical vapor deposition (PECVD) process. PLLA/SiO film showed Young's modulus and tensile strength increased by 119.2% and 91.6%, respectively, over those of neat PLLA film. At 5 °C, the oxygen (O ) and carbon dioxide (CO ) permeability of PLLA/SiO film decreased by 78.7% and 71.7%, respectively, and the CO /O permselectivity increased by 32.5%, compared to that of the neat PLLA film. When the PLLA/SiO film was applied to the equilibrium-modified atmosphere packaging of chilled meat, the gas composition in packaging reached a dynamic equilibrium with 6% to 11% CO and 8% to 13% O . Combined with tea polyphenol pads, which effectively inhibited the microbial growth, the desirable color of meat was maintained and an extended shelf life of 52 d was achieved for the chilled meat.

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The liquid−liquid-phase equilibrium of a five-component system of methanol−water−H2O2−trimethylbenzene−trioctyl phosphate was studied, and the data were correlated with UNIQUAC and NRTL models, respectively, and used for the simulation of the extraction of H2O2 with an aqueous methanol solution in the H2O2 production process based on anthraquinone hydrogenation−oxidation cycles. The results showed that, with an aqueous methanol solution for the extraction of H2O2, after a few cycles the concentration of methanol in an anthraquinone working solution becomes constant and would not influence the H2O2 production process. All of the impurities in the H2O2 solution obtained with an aqueous methanol solution as the extractant from the H2O2 generation process as well as the stabilizers and corrosion inhibitors that should be added in the H2O2 solution did not appreciably affect the direct ammoximation of cyclohexanone with NH3 and H2O2 catalyzed by TS-1. The results indicated that the processes of cyclohexanone oxime production through the direct ammoximation of cyclohexanone and H2O2 generation through the anthraquinone hydrogenation−oxidation cycles could be integrated.

The aim of the present study was to investigate whether the serum levels of complements and high-sensitivity C-reactive protein (hs-CRP) in patients with acute myocardial infarction (AMI) are associated with the severity of myocardial injury. Consecutive patients (n=110) with AMI and 33 healthy individuals, who served as control subjects, were enrolled from May 2013 to February 2015. These patients were divided into two groups, those with ST segment elevation MI (STEMI) and those with non-ST segment elevation MI (NSTEMI). The patients with STEMI exhibited progression to diastolic dysfunction and heart failure. Furthermore, the results revealed that the level of serum complement and hs-CRP in patients with AMI increased rapidly when compared with the subjects from the control group, particularly in the STEMI patients, at different time-points. A statistically significant elevation of the complement and hs-CRP levels was observed at day 3 after AMI in the STEMI group. The activation of complement and hs-CRP following AMI may serve as a specific marker to successfully predict left ventricular dysfunction. Thus, biomarker-based approaches may be adopted to identify the severity of AMI with distinct pathophysiologic responses in order to rationally implement clinical therapeutic strategies.

Unexpected syn beta-amino-alpha-bromination of unsaturated phosphonates was observed under typical Sharpless AA reaction conditions with excess N-bromoacetamide.