Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients

Guo, Liling; Chen, Yanqiao; Lin, Qiuzhen; Tian, Feng; Xiang, Qunyan; Zhu, Liyuan; Xu, Jin; Wen, Tie; Liu, Ling

doi:10.3389/fcvm.2021.649181

Cited by 9 publications

(10 citation statements)

References 32 publications

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“…It is a little different between previous researches and our study that the altitude of participants living. Our results have been partly con rmed by other researchers (39,40) who established that non-HDL-C was more stable than LDL-C and showed signi cantly higher predictive value.…”

Section: Discussionsupporting

confidence: 85%

Association of Elevated Non-HDL-C and LDL-C with Carotid atherosclerosis among Tibetans Living at High Altitudes: A Cross-sectional Study

Zhang

Gou

et al. 2022

Preprint

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Background: Hypoxic circumstances impair endothelial function and may contribute to carotid atherosclerosis. In high-altitude areas, there is a scarcity of data on the correlation between lipid particles and carotid atherosclerosis. Methods: A total of 587 patients who underwent carotid artery ultrasound and met the inclusion and exclusion criteria were enrolled in our cross-sectional study. All participants resided in Luhuo County, Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China (mean altitude: 3,860 meters). We used questionnaires, physical examination, blood sample testing, and ultrasound in our investigation. Spearman correlation analysis and multiple linear regression analysis were performed to explore the association between lipid particles and carotid atherosclerosis. We compared the disparity between lipid particles in predicting atherosclerosis using the receiver operator characteristic curve.Results: We found a statistically significant association between lipid particles and carotid atherosclerosis. After adjustment for certain variables, including age, gender, mean arterial pressure, and fasting blood glucose, we discovered that non-high-density lipoprotein-cholesterol (non-HDL-C) was a risk factor for carotid intima-media thickness (β = 0.012, p = 0.032) but not for low-density lipoprotein cholesterol (LDL-C) (p = 0.073). In terms of lifestyle, non-HDL-C was also found to be a risk factor for atherosclerosis independent of cigarette smoking and vegetarian (β = 0.012, p = 0.049). The area under the curve (AUC) of non-HDL-C was 0.644 (CI: 0.583 – 0.706) while LDL-C was 0.599 (CI: 0.534 - 0.664) in predicting carotid atherosclerosis. The optimal cut-off value of non-HDL-C was 3.625 mmol/L in predicting carotid plaques. Conclusions: Among Tibetans living in high-altitude areas, non-HDL-C is a better biomarker than LDL-C for carotid artery atherosclerosis independent of conventional risk factors. It is crucial to resolve non-HDL-C dyslipidemia in order to mitigate carotid atherosclerosis in Tibetans living at high-altitude settings.

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Section: Discussionsupporting

confidence: 85%

Association of Elevated Non-HDL-C and LDL-C with Carotid atherosclerosis among Tibetans Living at High Altitudes: A Cross-sectional Study

Zhang

Gou

et al. 2022

Preprint

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“…It is worth noting that measurement of either a fasting or non-fasting lipid profile is effective in estimating cardiovascular risk ( 39 ) and for documenting a baseline LDL-C level to evaluate cholesterol control in patients with CHD ( 40 ). In other words, the non-fasting reduction in LDL-C level either obvious or not in Chinese subjects should not be a factor interfering with the application of non-fasting blood lipid detection in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…It supported that it is feasible to detect the non-fasting non-HDL-C level in Chinese patients at high or very high risk of ASCVD during the day. Recently, it was reported that non-HDL-C level was more stable than LDL-C level in assessing the percent attainment of the non-fasting lipids for Chinese patients with CHD ( 40 ). It indicated that non-HDL-C level could be quite important, either in the fasting or non-fasting state, especially when considering it nearly covers the cholesterol of all atherosclerotic lipoproteins in the circulation.…”

Section: Discussionmentioning

confidence: 99%

Non-fasting Changes in Blood Lipids After Three Daily Meals Within a Day in Chinese Inpatients With Cardiovascular Diseases

Tan

Lin

et al. 2022

Front. Cardiovasc. Med.

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BackgroundNon-fasting (i.e., postprandial) lipid detection is recommended in clinical practice. However, the change in blood lipids in Chinese patients with cardiovascular diseases after three daily meals has never been reported yet.MethodsSerum levels of blood lipids were measured or calculated in 77 inpatients (48 men and 29 women) at high or very high risk of atherosclerotic cardiovascular disease (ASCVD) in the fasting state and at 4 h after three meals within a day according to their diet habits.ResultsFemale patients showed significantly higher level of high-density lipoprotein cholesterol (HDL-C) than male patients, and the gender difference in other lipid parameters did not reach statistical significance at any time-point. Levels of triglyceride (TG) and remnant cholesterol (RC) increased, while that of low-density lipoprotein cholesterol (LDL-C) decreased significantly after three meals (p < 0.05). Levels of HDL-C, total cholesterol (TC), and non-high-density lipoprotein cholesterol (non-HDL-C) showed smaller changes after three meals. Percent reductions in the non-fasting LDL-C levels after lunch and supper were around 20%, which were greater than that after breakfast. The percent reductions in the non-fasting non-HDL-C levels after three meals were smaller than those in the non-fasting LDL-C levels. Patients with TG level ≥ 2.0 mmol/L (177 mg/dL) after lunch had significantly greater absolute reduction of LDL-C level than those with TG level < 2.0 mmol/L (177 mg/dL) after lunch [–0.69 mmol/L (–27 mg/dL) vs. –0.36 mmol/L (–14 mg/dL), p<0.01]. There was a significant and negative correlation between absolute change in LDL-C level and that in TG level (r = −0.32) or RC level (r = −0.67) after lunch (both p<0.01).ConclusionLDL-C level decreased significantly after three daily meals in Chinese patients at high or very high risk of ASCVD, especially when TG level reached its peak after lunch. Relatively, non-HDL-C level was more stable than LDL-C level postprandially. Therefore, when LDL-C level was measured in the non-fasting state, non-HDL-C level could be evaluated simultaneously to reduce the interference of related factors, such as postprandial hypertriglyceridemia, on detection.

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“…It has been suggested that the clinical bene t afforded by controlling the non-HDL-C level is better than that available by controlling the LDL-C level [24]. Non-HDL-C assessment is better than LDL-C evaluation when exploring the percentage attainments of non-fasting lipid levels that improve the coronary health of dialysis patients [23].…”

Section: Discussionmentioning

confidence: 99%

Non-high-density Lipoprotein Cholesterol May Predict the Cardio-cerebrovascular Risk in Patients on Maintenance Hemodialysis

Luo

Zou

et al. 2021

Preprint

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BackgroundNon-high-density lipoprotein cholesterol (non-HDL-C) may be an independent risk factor for cardio-cerebrovascular disease (CVD); however, the cutoff level in patients on maintenance hemodialysis (MHD) is unknown. MethodsWe performed a multicenter retrospective study of MHD patients treated at 10 dialysis centers in Guangdong Province from July 1, 2016, to April 1, 2017. We collected laboratory test data and recorded CVD complications and outcomes. ResultsA total of 1,288 patients were enrolled; the non-HDL-C interquartile range was 2.76 (2.24–3.45) mmol/L. Over a median follow-up time of 23 months, 142 patients developed CVD. The non-HDL-C level was a principal risk factor for such events (P < 0.05; area under the curve 0.822, 95% confidence interval 0.800–0.842). The maximum Youden index was 0.549 and the best cutoff > 3.39 mmol/L. ConclusionHigher baseline non-HDL-C levels are associated with an increased risk of CVD in MHD patients. Thus, non-HDL-C effectively predicts CVD.

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Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients

Cited by 9 publications

References 32 publications

Association of Elevated Non-HDL-C and LDL-C with Carotid atherosclerosis among Tibetans Living at High Altitudes: A Cross-sectional Study

Association of Elevated Non-HDL-C and LDL-C with Carotid atherosclerosis among Tibetans Living at High Altitudes: A Cross-sectional Study

Non-fasting Changes in Blood Lipids After Three Daily Meals Within a Day in Chinese Inpatients With Cardiovascular Diseases

Non-high-density Lipoprotein Cholesterol May Predict the Cardio-cerebrovascular Risk in Patients on Maintenance Hemodialysis

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