Non-high-density Lipoprotein Cholesterol May Predict the Cardio-cerebrovascular Risk in Patients on Maintenance Hemodialysis

Abstract

BackgroundNon-high-density lipoprotein cholesterol (non-HDL-C) may be an independent risk factor for cardio-cerebrovascular disease (CVD); however, the cutoff level in patients on maintenance hemodialysis (MHD) is unknown. MethodsWe performed a multicenter retrospective study of MHD patients treated at 10 dialysis centers in Guangdong Province from July 1, 2016, to April 1, 2017. We collected laboratory test data and recorded CVD complications and outcomes. ResultsA total of 1,288 patients were enrolled; the non-HDL-C interquartile range was 2.76 (2.24–3.45) mmol/L. Over a median follow-up time of 23 months, 142 patients developed CVD. The non-HDL-C level was a principal risk factor for such events (P < 0.05; area under the curve 0.822, 95% confidence interval 0.800–0.842). The maximum Youden index was 0.549 and the best cutoff > 3.39 mmol/L. ConclusionHigher baseline non-HDL-C levels are associated with an increased risk of CVD in MHD patients. Thus, non-HDL-C effectively predicts CVD.