Non-Escherichia coli Versus Escherichia coli Community-Acquired Urinary Tract Infections in Children Hospitalized in a Tertiary Center

Marcus, Nir; Ashkenazi, Shai; Yaari, Arnon; Samra, Zmira; Livni, Gilat

doi:10.1097/01.inf.0000168743.57286.13

Cited by 79 publications

(51 citation statements)

References 17 publications

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“…were often isolated, as expected considering the age of our cohort [17]. As reported in previous studies [25], non-E. coli pathogens are more resistant to most antimicrobial agents (amoxicillin-clavulanate, cephalosporin, nitrofurantoin and amikacin); thus, empirical antibiotic therapy may not always be appropriate.…”

Section: Spectrum Of Uropathogensmentioning

confidence: 62%

Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

et al. 2014

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Section: Spectrum Of Uropathogensmentioning

confidence: 62%

Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

et al. 2014

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“…10 According to the Kids' Inpatient Database 2009, there are 48,100 annual admissions for patients less than 20 years of age with a discharge diagnosis code of UTI in the United States. 1 This suggests that nearly 4800 children with UTI could be affected by discordant therapy annually.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 Discordant antibiotic therapy, initial antibiotic therapy to which the causative bacterium is not susceptible, occurs in up to 9% of children hospitalized for UTI. 10 However, there is reason to believe that discordant therapy may matter less for UTIs than for infections at other sites. First, in adults hospitalized with UTIs, discordant initial therapy did not affect the time to resolution of symptoms.…”

mentioning

confidence: 99%

Discordant antibiotic therapy and length of stay in children hospitalized for urinary tract infection

Jerardi

Auger

Shah

et al. 2012

Journal of Hospital Medicine

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“…In vitro resistance is a significant problem, not only in complicated UTIs, but also in community-acquired urinary infections. Escherichia coli is the most frequent etiological agent, accounting for 65%-90% of urinary infections [1][2][3][4]. Frequent use of wide-spectrum antibiotics may change the intestinal flora, and as a consequence, induce bacterial resistance [5,6].…”

mentioning

confidence: 99%

Antibiotic resistance patterns of pediatric community-acquired urinary infections

Guidoni¹,

Berezin²,

Nigro³

et al. 2008

Braz J Infect Dis

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Knowledge about antimicrobial resistance patterns of the etiological agents of urinary tract infections (UTIs) is essential for appropriate therapy. Urinary isolates from symptomatic UTI cases attended at Santa Casa University Hospital of São Paulo from August 1986 to December 1989 and August 2004 to December 2005 were identified by conventional methods. Antimicrobial resistance testing was performed by Kirby Bauer's disc diffusion method. Among the 257 children, E. coli was found in 77%. A high prevalence of resistance was observed against ampicillin and TMP/SMX (55% and 51%). The antibiotic resistance rates for E. coli were: nitrofurantoin (6%), nalidixic acid (14%), 1 st generation cephalosporin (13%), 3 rd generation cephalosporins (5%), aminoglycosides (2%), norfloxacin (9%) and ciprofloxacin (4%). We found that E. coli was the predominant bacterial pathogen of community-acquired UTIs. We also detected increasing resistance to TMP/SMX among UTI pathogens in this population. Key-Words: Urinary tract infection, pediatrics urinary tract infection, bacterial resistance, Escherichia coli.Urinary tract infection (UTI) is a common cause of fever and one of the most common community-acquired infections. In vitro resistance is a significant problem, not only in complicated UTIs, but also in community-acquired urinary infections. Escherichia coli is the most frequent etiological agent, accounting for 65%-90% of urinary infections [1][2][3][4]. Frequent use of wide-spectrum antibiotics may change the intestinal flora, and as a consequence, induce bacterial resistance [5,6].The American Academy of Pediatrics, the Royal College of Physicians of London and the National Guideline Clearinghouse recommend empirical and precocious treatment of UTI, based on the susceptibility standard to the antimicrobials that are habitually utilized, with the objective of reducing risks of pyelonephritic scarring [7]. There is a paucity of literature concerning antibiotic therapy for uncomplicated UTI in the developing world. Increasing rates of resistance among bacterial uropathogens has caused growing concern in both developed and developing countries [8]. We evaluated the frequency of uropathogens in a community of São Paulo, Brazil, and we examined the antimicrobial susceptibility of E. coli and other uropathogens. Additionally, we compared the antimicrobial susceptibility of E. coli between two periods. Material and Methods PatientsThe study population consisted of children younger than 17 years old, who had culture-proven UTI evaluated in the pediatrics department of Santa Casa Hospital, from August 2004 to December 2005 and August 1986 to December 1989. The exclusion criteria were previous hospitalization (<30 days), presence of catheters and vesicle continent derivation (Mitrofanoff procedure). Urine CultureEpisodes of UTI were identified by positive urine culture. Cultures were obtained from midstream-collected urine or transurethral bladder catheterization. Bacterial identification and determination of antimicrobial susceptibilit...

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Non-Escherichia coli Versus Escherichia coli Community-Acquired Urinary Tract Infections in Children Hospitalized in a Tertiary Center

Cited by 79 publications

References 17 publications

Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

Discordant antibiotic therapy and length of stay in children hospitalized for urinary tract infection

Antibiotic resistance patterns of pediatric community-acquired urinary infections

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