Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

Alberici, Irene; Bayazıt, Aysun Karabay; Drożdż, Dorota; Emre, Sevinç; Fischbach, Michel; Harambat, Jérôme; Jankauskienė, Augustina; Litwin, Mieczysław; Mır, Sevgı; Morello, William; Peco-Antić, Amira; Sartipy, Peter; Sever, Lale; Simonetti, Giacomo D.; Szcześniak, Przemysław; Teixeira, Ana; Vidal, Enrico; Wuehl, Elke; Mehls, Otto; Weber, Lutz T.; Schaefer, Franz; Montini, Giovanni

doi:10.1007/s00431-014-2459-3

Cited by 38 publications

(28 citation statements)

References 32 publications

(31 reference statements)

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“…There is a growing problem of resistance to antibiotics in GNBs, which cause sepsis in neonates and UTIs in children (4,5,(9)(10)(11). A significant proportion of UTIs in the infants in our study were caused by GNBs that were resistant to several antibiotic classes and 11.8% were MDR.…”

Section: Discussionmentioning

confidence: 60%

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Infants under two months of age with urinary tract infections are showing increasing resistance to empirical and oral antibiotics

et al. 2016

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Section: Discussionmentioning

confidence: 60%

“…Urinary tract infections (UTIs) are frequent causes of serious bacterial infections in infants in the first weeks of life (1)(2)(3). Several studies have reported antibiotic resistance to bacteria causing UTIs in children (4,5). Data on infants up to the age of three months are scarce.…”

Section: Introductionmentioning

confidence: 99%

Infants under two months of age with urinary tract infections are showing increasing resistance to empirical and oral antibiotics

et al. 2016

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“…Other isolated bacterial strains were Klebsiella, Enterococcus, Proteus, and Pseudomonas, not only from hospital settings. This underlines the fact that E. coli is the most common organism causing UTIs in infants, however other bacterial strains are now being isolated more frequently than in the past [15].…”

Section: Etiology/physiopathologymentioning

confidence: 96%

“…There is no gold standard empirical antibiotic treatment; resistance patterns can be very different between countries, as demonstrated by the above-mentioned recent European survey [15], which evaluated the resistance patterns of E. coli. A high rate of resistance to amoxicillin was reported by almost all the centers.…”

Section: Treatment and Hospitalizationmentioning

confidence: 99%

Acute pyelonephritis in children

et al. 2015

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Acute pyelonephritis is one of the most serious bacterial illnesses during childhood. Escherichia coli is responsible in most cases, however other organisms including Klebsiella, Enterococcus, Enterobacter, Proteus, and Pseudomonas species are being more frequently isolated. In infants, who are at major risk of complications such as sepsis and meningitis, symptoms are ambiguous and fever is not always useful in identifying those at high risk. A diagnosis of acute pyelonephritis is initially made on the basis of urinalysis; dipstick tests for nitrites and/or leukocyte esterase are the most accurate indicators of infection. Collecting a viable urine sample for urine culture using clean voided methods is feasible, even in young children. No gold standard antibiotic treatment exists. In children appearing well, oral therapy and outpatient care is possible. New guidelines suggest less aggressive imaging strategies after a first infection, reducing radiation exposure and costs. The efficacy of antibiotic prophylaxis in preventing recurrence is still a matter of debate and the risk of antibiotic resistance is a warning against its widespread use. Well-performed randomized controlled trials are required in order to better define both the imaging strategies and medical options aimed at preserving long-term renal function.

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“…It is used empirically before the urine culture and sensitivity test. E. coli is the most common causative pathogen of UTI in children (ranging from <50% to 62.4%) [15][16][17] and has a high resistance to both amoxicillin 15 and ampicillin. 16,17 Brady et al reported that short-duration (≤3 day) i.v.…”

Section: Discussionmentioning

confidence: 99%

Risk factors affecting the prognosis of urinary tract infection in Chinese pediatric patients: Single‐center experience

Wang

Zhu

Huang

et al. 2020

Pediatrics International

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Background Urinary tract infection (UTI) is common in children. The purpose of this retrospective study was to determine the various risk factors that usually affect the prognosis of UTI in children diagnosed with the disease. Methods In the present retrospective study, we enrolled all pediatric patients diagnosed with UTI and hospitalized between 1 January 2013 and 31 July 2016 at Nanjing Children's Hospital. We then collected all the relevant patient clinical demographics and characteristics. Results The study involved 2,092 pediatric patients diagnosed with UTI. On logistic regression analysis, factors that could affect the prognosis of pediatric UTI were complications, hospitalization, intensive care unit (ICU) admission, type of UTI, urine culture results, blood lymphocytes, urine nitrites (NIT) and antibiotics (unstandardized coefficients, 0.06, <0.001, −0.28, 0.32, <0.001, 0.01, −0.11, 0.01, respectively, all P < 0.001). Conclusion Complications, hospitalization, type of UTI, urine culture results, blood lymphocytes, and antibiotics had a significant, positive association with UTI prognosis. Meanwhile, ICU admission and urine NIT had a negative association with prognosis.

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Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

Abstract: E. coli is the most common organism causing UTIs in infants; however, other bacterial strains are frequently isolated. As a result, antibiotic prophylaxis should be more elastic and adaptable over time in order to guarantee maximum efficacy.

Cited by 38 publications

References 32 publications

Infants under two months of age with urinary tract infections are showing increasing resistance to empirical and oral antibiotics

Infants under two months of age with urinary tract infections are showing increasing resistance to empirical and oral antibiotics

Acute pyelonephritis in children

Risk factors affecting the prognosis of urinary tract infection in Chinese pediatric patients: Single‐center experience

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