Non-enzymatic glucose sensing based on hierarchical platinum micro-/nanostructures

Unmüssig, Tobias; Weltin, Andreas; Urban, Sebastian; Daubinger, Patrick; Urban, G.; Kieninger, Jochen

doi:10.1016/j.jelechem.2018.03.061

Cited by 43 publications

(20 citation statements)

References 48 publications

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“…A representative real‐time current response of the MWCNT/PtNP/PPD‐based interface to H 2 O 2 is shown in Figure e. It is worth mentioning that the demonstrated sensitivity to H 2 O 2 is superior to those reported previously …”

Section: Resultsmentioning

confidence: 79%

A Mediator‐Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring

Cheng

Wang

Zhao

et al. 2019

Adv Funct Materials

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Wearable electroenzymatic sensors enable monitoring of clinically informative biomolecules in epidermally retrievable biofluids. Conventional wearable enzymatic sensors utilize Prussian Blue (a redox mediator) to achieve selectivity against electroactive interferents. However, the use of Prussian Blue presents fundamental challenges including: 1) the susceptibility of the sensor response to dynamic concentration variation of ionic species and 2) the poor operational stability due to the degradation of its framework. As an alternative wearable electroenzymatic sensor development methodology to bypass the aforementioned limitations, a mediator‐free sensing interface is devised, comprising of a coupled platinum nanoparticle/multiwall carbon nanotube layer and a permselective membrane. The interface is adapted to develop sensors targeting glucose, lactate, and choline (as examples of informative metabolites and nutrients), showing high degrees of sensitivity, selectivity (against a wide panel of naturally present and diverse interfering species), stability (<6.5% signal drift over 20 h operation), and reliability of sensing operation in sweat samples. By integration within a readout board, a wireless sample‐to‐answer system is realized for on‐body sweat biomarker analysis. This methodology can be adapted to target a wide panel of biomarkers in various biofluids, introducing a new sensor development direction for personal health monitoring.

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Section: Resultsmentioning

confidence: 79%

A Mediator‐Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring

Cheng

Wang

Zhao

et al. 2019

Adv Funct Materials

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“…Compared with a single Pt or Au electrode (4 mm in diameter) modified with Pt flowers, the detection range was much wider from 1–30 × 10 −3 m and a better linearity (correlation coefficient 0.9989) was observed, demonstrating good performance for glucose detection. Table 2 compared the performance of some glucose sensors with some widely reported materials . The sensitivity for glucose determination at the IrO x /Pt microelectrode was ≈130 µA cm −2 m m −1 , the detection limit was 1.08 × 10 −6 m with a signal‐to‐noise ratio (SNR) of 3, which was comparable and even better than those best records.…”

Section: Resultsmentioning

confidence: 91%

Well Controlled 3D Iridium Oxide/Platinum Nanocomposites with Greatly Enhanced Electrochemical Performances

Zeng

Xia

Zhang

et al. 2019

Adv Materials Inter

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It is crucial to improve charge storage capacity (CSC) and charge transport efficiency with low impedance for electrochemical capacitors. Here, a well‐controlled three‐dimensional (3D) nanocrystal platinum (Pt) is electrodeposited as the intermediate layer on microelectrode (200 µm in diameter) to provide extensive large surface area, followed by introducing iridium oxide (IrOx) nanoparticles with excellent adhesion on the rough layer to fabricate high‐performance IrOx/Pt composite coatings. The uniform flower‐shaped coating presents a significantly low impedance ≈2.01 kΩ at 1 kHz (reduction of 94.52%). It has a cathodic CSC (CSCc) up to ≈200.64 mC cm−2, about 2, 17.51, and 56.18 times higher than that of nanocrystal Pt, IrOx, and flat Pt respectively. Robust chronic stability is observed with CSCc at ≈171.97 mC cm−2 after electrical stimulation for 12 d (>1 × 108 cycles). It also demonstrates record‐high charge injection capacity ≈6.37 mC cm−2 with excellent biocompatibility. Such coating is widely applicable for batch production on multichannel microelectrode arrays or substrates with different sizes. Moreover, it promotes excellent sensitivity to glucose detection up to ≈130 µA cm−2 mm−1, with a linear range of 1–30 × 10−3 m and a detection limit of 1.08 × 10−6 m. The promising coating will pave a new way for various electrochemical applications.

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“…Strategies to overcome the Pt limitations comprise nanoengineering the Pt surface, fabricating nanocomposite structures, adjusting surface morphology, roughness, and increasing porosity [ 147 , 157 , 158 , 159 , 160 ]. Additionally, the fabrication of nanocomposite Pt-based structures is a widely used approach to improve the catalytic efficiency of noble metals [ 22 , 134 , 144 ].…”

Section: Recent Developments In Non-enzymatic Glucose Sensorsmentioning

confidence: 99%

Recent Advances in Enzymatic and Non-Enzymatic Electrochemical Glucose Sensing

Hassan

Vyas

Grieve

et al. 2021

Sensors

187

111

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The detection of glucose is crucial in the management of diabetes and other medical conditions but also crucial in a wide range of industries such as food and beverages. The development of glucose sensors in the past century has allowed diabetic patients to effectively manage their disease and has saved lives. First-generation glucose sensors have considerable limitations in sensitivity and selectivity which has spurred the development of more advanced approaches for both the medical and industrial sectors. The wide range of application areas has resulted in a range of materials and fabrication techniques to produce novel glucose sensors that have higher sensitivity and selectivity, lower cost, and are simpler to use. A major focus has been on the development of enzymatic electrochemical sensors, typically using glucose oxidase. However, non-enzymatic approaches using direct electrochemistry of glucose on noble metals are now a viable approach in glucose biosensor design. This review discusses the mechanisms of electrochemical glucose sensing with a focus on the different generations of enzymatic-based sensors, their recent advances, and provides an overview of the next generation of non-enzymatic sensors. Advancements in manufacturing techniques and materials are key in propelling the field of glucose sensing, however, significant limitations remain which are highlighted in this review and requires addressing to obtain a more stable, sensitive, selective, cost efficient, and real-time glucose sensor.

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Non-enzymatic glucose sensing based on hierarchical platinum micro-/nanostructures

Cited by 43 publications

References 48 publications

A Mediator‐Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring

A Mediator‐Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring

Well Controlled 3D Iridium Oxide/Platinum Nanocomposites with Greatly Enhanced Electrochemical Performances

Recent Advances in Enzymatic and Non-Enzymatic Electrochemical Glucose Sensing

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