Non-cryopreserved peripheral blood progenitor cells collected by a single very large-volume leukapheresis: A simplified and effective procedure for support of high-dose chemotherapy

Performance and safety of femoral central venous catheters in pediatric autologous peripheral blood stem cell collection

“…These results are equivalent or better than those reported in adults (Table ) . Shariatmadar and Noto reported bleeding in 1/63 (1.6%) of autologous adult patients, with no episodes of occlusion or flow‐related AE, even after 6 days .…”

“…These results are equivalent or better than those reported in adults (Table 5). 1,4,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] Shariatmadar and Noto reported bleeding in 1/63 (1.6%) of autologous adult patients, with no episodes of occlusion or flow-related AE, even after 6 days. 24 In contrast, Moreiras-Plaza et al encountered catheter-related flow issues in 12% (29/232) of procedures that were resolved by patient repositioning or reversing lines: other AE included minor bleeding after insertion (2%) and hematoma (15.8%).…”

Retention of cellular properties of PBPCs following liquid storage and cryopreservation

“…Autologous PBPC units are usually cryopreserved and allogeneic PBPC units are infused within 24 hours of apheresis collection. A number of studies, laboratory and clinical, have demonstrated that PBPC properties, including engraftment potential, were not altered by storage for 24 hours in cold (1‐6°C) or at ambient temperatures (20‐24°C) 1‐4 . The use of allogeneic PBPCs has been extended to older patients with nonablative conditioning 5,6 and new indications, such as renal cell carcinoma 7 .…”