Non-Chinese herbal medicines for functional dyspepsia

Baez, German Nicolas; Vargas, Camila Lehnhart; Arancibia, Marcelo; Papuzinski, Cristian; Franco, Juan VA

doi:10.1002/14651858.cd013323.pub2

Cited by 4 publications

(1 citation statement)

References 126 publications

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“…Completeness of the clinical data was ensured by performing a literature review, which revealed no additional published clinical trials investigating STW 5-II in FD. A recently published systematic review and meta-analysis on herbal medications did not specifically focus on the efficacy of STW 5-II in FD [23]. The main inclusion criteria were FD symptoms consistent with the Rome IV criteria, comprising at least one of the key symptoms of fullness, early satiety, and upper abdominal pain, rated as moderate.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of STW 5-II for Functional Dyspepsia Treatment: A Patient Data-Based Meta-Analysis

Andresen,

Shah,

Fink

et al. 2024

Digestion

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Introduction: Functional dyspepsia (FD) is a chronic relapsing gastroduodenal disorder with limited treatment options. Herbal products, like the six-herb combination STW 5-II, can target multiple FD gastrointestinal symptoms. In this meta-analysis, we evaluated the efficacy and safety of STW 5-II for overall FD, and key symptoms, based on Rome IV criteria. Methods: We systematically screened the literature for randomized controlled clinical studies testing STW 5-II in FD. Meta-analysis was performed using data from individual patients with at least one key FD symptom (fullness, early satiety, or epigastric pain) of at least moderate severity at baseline. ANCOVA-based meta-analyses were performed on improvements in the total symptom sum score, and single symptoms, after 4 and 8 weeks. Safety data were analyzed by calculating odds ratios for all adverse events. Results: Four randomized controlled trials, including 613 patients, were identified, and two were eligible for efficacy analysis. STW 5-II significantly improved the FD symptom sum score (mean difference of 1.74 after 4 weeks and 2.07 after 8 weeks) and key FD symptoms of fullness (0.28 and 0.29), early satiety (0.25 and 0.26), and epigastric/upper abdominal pain (0.26 and 0.3). Treatment-related or severe adverse events did not differ between STW 5-II and placebo. Conclusion: The results support that STW 5-II significantly improves FD symptoms after 4 and 8 weeks of treatment with no difference in relation to safety signals compared to placebo. Thus, STW 5-II can be considered an effective and safe treatment option for FD.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of STW 5-II for Functional Dyspepsia Treatment: A Patient Data-Based Meta-Analysis

Andresen,

Shah,

Fink

et al. 2024

Digestion

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Funktionelle Magen-Darm-Erkrankungen

Keller,

Kandulski

2023

Gastroenterologie

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Therapy of Upper Gastrointestinal Symptoms: Experience with a Medical Device Made of Natural Substances

Corazziari,

Ribichini

2024

Curr Treat Options Gastro

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Purpose of review Medical devices made of substances are widely used in clinical practice, but they are considered to have less therapeutic efficacy than pharmacological agents. In this narrative review, we report a recent RCT experience of a medical device made of natural substances (Poliprotect) that proved as effective as the standard reference treatment. The RCT addressed three questions: (1) Is Poliprotect useful in the initial treatment of heartburn and epigastric pain/burning as an alternative to the reference standard therapy with PPI, (2) is Poliprotect useful in the medium-term treatment of heartburn and epigastric pain/burning, and (3) is Poliprotect useful in the deprescribing phase of PPI? Recent findings Firstly, Poliprotect proved non-inferior to omeprazole for symptom relief in confirmed upper endoscopic negativity; secondly, the benefit remained unaltered after shifting to on-demand intake, with no gut microbiota variation; and thirdly, Poliprotect can be used to deprescribe the PPI treatment, avoiding the symptomatic worsening that accompanies the hyper secretive gastric acid rebound effect. Summary A medical device made of natural substances can be as effective as a pharmacological agent in the therapy of upper gastrointestinal symptoms in endoscopy-negative patients. Poliprotect effect started from the first day of treatment to improve in the following 2 weeks and to be maintained unaltered in the following 4 weeks with on-demand regimen. Finally, this medical device of natural substances showed high safety without affecting the gut microbiota.

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Non-Chinese herbal medicines for functional dyspepsia

Cited by 4 publications

References 126 publications

Efficacy and Safety of STW 5-II for Functional Dyspepsia Treatment: A Patient Data-Based Meta-Analysis

Efficacy and Safety of STW 5-II for Functional Dyspepsia Treatment: A Patient Data-Based Meta-Analysis

Funktionelle Magen-Darm-Erkrankungen

Therapy of Upper Gastrointestinal Symptoms: Experience with a Medical Device Made of Natural Substances

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