Non-adherence among patients initiating antiretroviral therapy: a challenge for health professionals in Brazil

Bonolo, Palmira de Fátima; César, Cibele Comini; Acúrcio, Francisco de Assis; Ceccato, Maria das Graças Braga; Pádua, Cristiane Aparecida Menezes de; Álvares, Juliana; Campos, Lorenza Nogueira; Carmo, Ricardo Andrade; Guimarães, Mark D. C.

doi:10.1097/01.aids.0000191484.84661.2b

Cited by 86 publications

(106 citation statements)

References 14 publications

(23 reference statements)

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“…Another factor of great importance that potentially contributes to the mortality is that low use of ART among those being cared for in renowned centers. The rate of non-use of ART in the first months of treatment is high (30-44%) 12 and the irregular use of it can reach up to 66% according to recent studies 13 . Brazil is a long way from the UNAIDS goal which includes 90% of infections having been diagnosed, 90% of these tied to ART services, and 90% of these with virologic control (90-90-90) with the ambitious proposal of eliminating HIV by 2030 14 .…”

Section: Discussionmentioning

confidence: 99%

Mortalidade por HIV/Aids no Brasil, 2000-2015: motivos para preocupação?

Guimarães

Carneiro

Abreu

et al. 2017

Rev. bras. epidemiol.

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RESUMO: Introdução e objetivo: Estudos de mortalidade são fundamentais no monitoramento da epidemia de HIV/Aids. Qualidade e completude dos dados do sistema de informação de mortalidade (SIM) requerem abordagens complementares. Métodos: Foram utilizadas duas fontes de dados para avaliação das tendências de mortalidade por HIV/Aids no Brasil entre 2000 e 2014/15: a) dados do SIM publicados pelo Departamento de DST, Aids e Hepatites Virais; e b) estudos de carga de doença 2015 (GBD 2015). Foi conduzida a análise descritiva e realizada uma comparação das tendências de redução relativa dos coeficientes de mortalidade por 100 mil, padronizados por idade. Resultados: A magnitude dos coeficientes de mortalidade estimados pelo GBD para o Brasil e estados foi maior do que a daqueles obtidos pelo SIM. A redução relativa foi maior para os dados gerados pelo SIM e houve mudança de ranking de acordo com os estados. Entre 2000 e 2014/15, houve aumento nos coeficientes de mortalidade para a maioria dos estados (78 e 88%, segundo o SIM e o GBD, respetivamente). Conclusões: São preocupantes os dados sobre mortalidade por HIV/Aids no Brasil, independentemente do método utilizado. As diferenças de magnitude, redução relativa e ranking podem ser atribuídas a diferenças metodológicas, sendo o GBD mais abrangente e com maior capacidade de captar dados classificados incorretamente, não registrados ou não codificados como causa de óbito devido ao HIV/Aids. O estudo de fontes complementares e metodologias alternativas podem fornecer importantes subsídios para as políticas públicas de HIV/Aids no Brasil.

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Section: Discussionmentioning

confidence: 99%

Mortalidade por HIV/Aids no Brasil, 2000-2015: motivos para preocupação?

Guimarães

Carneiro

Abreu

et al. 2017

Rev. bras. epidemiol.

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“…The present analysis was part of a prospective study on adherence to ART carried out at two public AIDS-referral centers in the city of Belo Horizonte, Minas Gerais State, Brazil 15 . Patients receiving their first antiretroviral (ARV ) prescription from May 2001 through May 2002 were recruited and followed up to May 2003.…”

Section: Subjects and Recruitmentmentioning

confidence: 99%

Vulnerability and non-adherence to antiretroviral therapy among HIV patients, Minas Gerais State, Brazil

et al. 2008

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“…Non-adherence is multifactorial and several groups of variables have been implicated in its occurrence ranging from individual to health service and social factors 2,4,15,24 .…”

Section: Introductionmentioning

confidence: 99%

“…BONOLO et al 2 review 43 articles on adherence to HAART. They found a mean rate of non-adherence of 30.4%, range from 5% to 67%.…”

mentioning

confidence: 99%

Risk-factors for non-adherence to antiretroviral therapy

Silva

Ximenes

Filho

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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SUMMARYCross-sectional study analyzed as case-control to identify risk factors for non-adherence to antiretroviral therapy. We studied 412 out-clinics HIV infected subjects of three public hospitals of Recife, Pernambuco. The objective was to examine the association between non-adherence to the antiretroviral therapy and biological, social-behavior and demographics and economic factors, factors related to the disease and/or treatment, factors related to life habits and depression symptoms. Variables significantly associated with non-adherence to antiretroviral therapy were: time elapsed since HIV diagnosis (p = 0.002), daily dose (p = 0.046), use of alcohol (p = 0.030) and past drug use (p = 0.048), and borderline p-values were found for educational level (p = 0.093) and family monthly income (p = 0.08). In the multivariable analysis, the factors that remained in the final model were family monthly income, time period with HIV infection and use of alcohol. No association was observed between non-adherence to antiretroviral therapy and gender, age, sexual orientation, marital status, educational level and place of residence.Based on our results and the local situation we suggest: assessment of social needs; training of partners and/or families on supporting adherence, creation of "adherence groups" to motivate and to reassure patients on the benefits of treatment; counseling and/or psychotherapy for alcohol drinkers.

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Non-adherence among patients initiating antiretroviral therapy: a challenge for health professionals in Brazil

Cited by 86 publications

References 14 publications

Mortalidade por HIV/Aids no Brasil, 2000-2015: motivos para preocupação?

Mortalidade por HIV/Aids no Brasil, 2000-2015: motivos para preocupação?

Vulnerability and non-adherence to antiretroviral therapy among HIV patients, Minas Gerais State, Brazil

Risk-factors for non-adherence to antiretroviral therapy

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