No link between low‐grade periodontal disease and preterm birth: a pilot study in a healthy Caucasian population

Holbrook, W. P.; Óskarsdóttir, Ásta; Fridjónsson, Theódór; Einarsson, Hrólfur; Hauksson, Arnar; Geirsson, Reynir Tómas

doi:10.1080/00016350410001522

Cited by 53 publications

(67 citation statements)

References 9 publications

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“…Two studies published their preliminary results (n = 176 women), but their full results were not available at the time of writing. 251,258 The accuracy of one study was not evaluated further because data were not extractable from the publication and the corresponding author was not able to provide it within the time scale of this project. 253 There was no study evaluating the accuracy of periodontal assessment as a predictor of spontaneous preterm birth in women who presented with threatened preterm labour.…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

185

146

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For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

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Section: Study Characteristics and Qualitymentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

185

146

View full text Add to dashboard Cite

show abstract

“…However, results have been mixed and several studies have not found associations between periodontal disease and preterm birth or low birthweight. (13)(14)(15) Systematic reviews of published studies tend to confirm a relationship between periodontal disease and preterm birth with an overall relative risk approaching 3. (16) Few studies on periodontal disease have examined women in developing countries, with very limited data available from Pakistan.…”

Section: Introductionmentioning

confidence: 99%

Periodontal disease and adverse birth outcomes: a study from Pakistan

Mobeen

Jehan

Banday

et al. 2008

American Journal of Obstetrics and Gynecology

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OBJECTIVES-Periodontal disease may increase the risk of adverse birth outcomes; however, results have been mixed. Few studies have examined periodontal disease in developing countries. We describe the relationship between periodontal disease and birth outcomes in a community setting in Pakistan. METHODS-Enrollment occurred at 20-26 wks.A study dentist performed the periodontal examination to assess probing depth (PD), clinical attachment level (CAL), gingivitis index (GI) and plaque index (PI). Outcomes included stillbirth, neonatal mortality, <32 wk preterm birth (PTB), 32-36 wk PTB, and low birthweight (LBW), and are presented for increasing periodontal disease severity by quartiles (Q1-4).RESULTS-Dental examinations and outcome data were completed for 1152 women. 81% were multiparous with a mean age of 27 yrs. 33% had no education. Dental caries were present in 47%, missing teeth in 27%, and 92% had no dental care in the last year. Periodontal disease was common: 87% had ≥ 4 teeth with a PD of >3mm, 54% had ≥4 teeth with a PI = 3, and 58% had ≥ 4 teeth with a GI = 3. In general, as the measure of periodontal disease increased, stillbirth, PTB <32 wks and neonatal mortality also increased. Late PTB and LBW were not related to measures of periodontal disease. Adjustment for demographic characteristics did not significantly change the relationships.

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“…The mRNA surveillance systems not only contribute to the maintenance of cellular homeostasis, but are also implicated in certain diseases (3,4). One of the best characterized mRNA surveillance pathways is nonsense-mediated mRNA decay (NMD), 3 in which the Upframeshift (Upf) complex composed of Upf protein 1 (Upf1), Upf2, and Upf3 recognizes and eliminates mRNAs containing a PTC. Translation termination at a PTC leads to the assembly of the Upf complex, which couples premature translation termination to mRNA decay by interacting with both eukaryotic translation termination factors (i.e.…”

mentioning

confidence: 99%

The Upf Factor Complex Interacts with Aberrant Products Derived from mRNAs Containing a Premature Termination Codon and Facilitates Their Proteasomal Degradation

Kuroha

Ando

Nakagawa

et al. 2013

Journal of Biological Chemistry

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Background: Up-frameshift (Upf) factors eliminate aberrant mRNAs that contain a premature termination codon (PTC). Results: The Upf complex was recruited to a PTC product and promoted the degradation of a model unfolded protein. Conclusion:Upf factors facilitate the ubiquitin-dependent degradation of products derived from mRNA containing specific PTCs. Significance: The findings reveal a mechanism of quality control that prevents the production of aberrant products derived from mRNAs containing specific PTCs.

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No link between low‐grade periodontal disease and preterm birth: a pilot study in a healthy Caucasian population

Cited by 53 publications

References 9 publications

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Periodontal disease and adverse birth outcomes: a study from Pakistan

The Upf Factor Complex Interacts with Aberrant Products Derived from mRNAs Containing a Premature Termination Codon and Facilitates Their Proteasomal Degradation

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