No Evidence of Involvement of<i>Chlamydia Pneumoniae</i>in Lung Cancer by Means of Quantitative Real-Time Polymerase Chain Reaction

Sessa, Rosa; Santino, Iolanda; M, Di Pietro; Schiavoni, Giovanna; Ripa, Chiara; Galdiero, Marilena; Iannone, Marie A.; Izzo, Luciano; Pi, Mingazzini; Bolognese, Alexandra C.; M, Del Piano

doi:10.1177/039463200802100221

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…Many clinical epidemiological studies analyzing the association between Cpn infection and the risk of lung cancer have been reported (Jackson et al, 2000;Koyi et al, 2001;Anttila et al, 2003;Kocazeybek, 2003;Littman et al, 2004;Littman et al, 2005;Chaturvedi et al, 2010), but no clear consensus has been reached (Koh et al, 2005;Sessa et al, 2008;Smith et al, 2008). This relationship was assessed more closely by performing a meta-analysis (Zhan et al, 2011) based on publications collected from electronic databases such as Pubmed, Embase, Web of Science, and CNKI.…”

Section: Discussionmentioning

confidence: 99%

An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

Chu

Guo²,

Pan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

Chu

Guo²,

Pan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The null association remained when limited to non-smokers (OR 1.01, 95% CI 0.55–1.83). However, a possible association among younger subjects aged 60 years and below could not be excluded (OR 1.70, 95% CI 0.79 –3.67) This study findings of a null association generally do not support the hypothesis that C. pneumoniae is independently associated with lung cancer among Chinese women, particularly in non-smokers Molecular-based investigation Sessa [ 18 ] An experimental study using lung biopsy specimens during surgery Investigated the presence of C. pneumoniae DNA in tumor lung tissues by using real-time PCR assay. Simultaneously, tumor and healthy tissues from the same patient with primary carcinoma lung were analyzed C. pneumoniae DNA was not detected in a single lung tumor tissue using a highly sensitive and specific real-time PCR assay based on FRET hybridization probes This study does not support C. pneumoniae in the pathogenesis of lung cancer, suggesting that further investigations are needed to clarify other potential causative factors for the development of this malignancy …”

Section: Resultsmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

“…Among the relevant literature, three case–control studies do not support the causal relationship between C. pneumoniae infection and lung cancer [ 18 – 20 ]. Out of three, one study looked for C. pneumoniae DNA by using PCR, while they failed to detect any [ 18 ]. The other two studies measured C. pneumoniae IgG and IgA titres, but there was no significant difference among cases and controls [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Chlamydia pneumoniae infections and development of lung cancer: systematic review

Premachandra

Jayaweera

2022

Infect Agents Cancer

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Background Chlamydia pneumoniae is an obligate intracellular pathogen and is a common cause of human respiratory diseases, including pneumonia. It has been already known to have a causal relationship with some chronic diseases such as chronic obstructive pulmonary disease, asthma, and atherosclerotic cardiovascular diseases. In this review, we aim to find out the association between C. pneumoniae infection and lung cancer. Methods This is a systematic review on C. pneumoniae infection and the development of lung cancer, based on published articles consolidated from PubMed and Google Scholar on the topic. Results Out of 46 articles, 27 were selected and screened through the process. Twenty-four articles positively supported the hypothesis with one animal model, while 3 of them were negatively supportive. Several proposed mechanisms explain the pathogenesis with some knowledge gaps. Conclusion Although some studies showed an association between C. pneumoniae infection and lung cancer, whether the C. pneumoniae infection is an individual risk factor for lung cancer is still debatable. And it needs further experimental studies on both humans and animals with large observational studies to better understand the association between C. pneumoniae infection and lung cancer.

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“…Furthermore, other studies [ 6 – 8 ] showed ORs of 1.2 to 2.8 after adjusting for smoking status, indicating that chronic Cpn infection is an independent risk factor for lung cancer. Several case-control studies showed that Cpn infection increased the risk of lung cancer development [ 10 – 13 , 16 ] but failed to show a correlation between serum Cpn antibodies and cancer risk [ 14 , 15 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Combined and interaction effect of chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in Southeast China

Liu

Xiong³

et al. 2020

BMC Cancer

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Background This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Cpn infection, smoking, and various environmental factors. Methods The study comprised 449 lung cancer patients and 512 age- and sex-matched healthy controls. All participants provided a 5 ml fasting peripheral venous blood sample for testing Cpn-specific IgG and IgA by using micro-immunofluorescence. Besides analyzing the associations between Cpn and lung cancer, combined effect analysis, logistic regression, and the Excel table made by Andersson were used to analyze the combined and interaction effects of Cpn and environmental factors on lung cancer. Results Compared to those with no evidence of serum Cpn IgA or Cpn IgG, those with both Cpn IgG+ and IgA+ had 2.00 times the risk (95% CI: 1.34–3.00) of developing lung cancer. Cpn IgG+ or IgA+ was associated with a significantly increased risk of lung cancer among smokers; the adjusted odds ratio (OR) was 1.79 (95% CI: 1.10–2.91) and 2.27 (95% CI: 1.38–3.72), respectively. Those exposed to passive smoking with Cpn IgG+ or IgA+ also showed an increased risk of lung cancer; the adjusted OR was 1.82 (95% CI: 1.20–2.77) or 1.87 (95% CI: 1.22–2.87), respectively. Similar results were also observed among alcohol drinkers. Multiplicative and additive interactions were not observed between Cpn infection and environmental factors. The combined effects of Cpn IgG+ or IgA+ with smoking, passive smoking, and family history of cancer on lung cancer were determined. Conclusion Cpn infection is potentially associated with primary lung cancer in the Chinese Han population and has combined effects with smoking, passive smoking, and family history of cancer.

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No Evidence of Involvement ofChlamydia Pneumoniaein Lung Cancer by Means of Quantitative Real-Time Polymerase Chain Reaction

Cited by 5 publications

References 24 publications

An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

Chlamydia pneumoniae infections and development of lung cancer: systematic review

Combined and interaction effect of chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in Southeast China

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