Chlamydia pneumoniae infections and development of lung cancer: systematic review

Premachandra, Nadeesha Madushani; Jayaweera, Jayaweera Arachchige Asela Sampath

doi:10.1186/s13027-022-00425-3

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…Furthermore, evidence suggest that C. pneumoniae and HPV infections may have a synergistic effect on promoting lung cancer development [65] , [66] . Both infections can independently induce cellular changes and genetic instability, increasing the susceptibility to malignant transformation [67] – [69] . The combination of these infections may lead to more severe and long-lasting inflammation and immune dysregulation, further promoting the development of lung cancer [67] – [69] .…”

Section: Discussionmentioning

confidence: 99%

Microbial infections as potential risk factors for lung cancer: Investigating the role of human papillomavirus and chlamydia pneumoniae

Drokow,

Effah,

Agboyibor

et al. 2023

AIMSPH

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<abstract><sec> <title>Background</title> Lung cancer is the leading cause of cancer morbidity and mortality worldwide. Apart from tobacco smoke and dietary factors, microbial infections have been reported as the third leading cause of cancers globally. Deciphering the association between microbiome and lung cancer will provide potential biomarkers and novel insight in lung cancer progression. In this current study, we performed a meta-analysis to decipher the possible association between <italic>C. pneumoniae</italic> and human papillomavirus (HPV) and the risk of lung cancer. </sec><sec> <title>Methods</title> Literature search was conducted in most English and Chinese databases. Data were analyzed using CMA v.3.0 and RevMan v.5.3 software (Cochrane-Mantel-Haenszel method) by random-effects (DerSimonian and Laird) model. </sec><sec> <title>Results</title> The overall pooled estimates for HPV studies revealed that HPV infections in patients with lung cancer were significantly higher than those in the control group (<italic>OR</italic> = 2.33, 95% <italic>CI</italic> = 1.57–3.37, <italic>p</italic> < 0.001). Base on subgroup analysis, HPV infection rate was significantly higher in Asians (<italic>OR</italic> = 6.38, 95% <italic>CI</italic> = 2.33–17.46, <italic>p</italic> < 0.001), in tissues (<italic>OR</italic> = 5.04, 95% <italic>CI</italic> = 2.27–11.19, <italic>p</italic> < 0.001) and blood samples (<italic>OR</italic> = 1.40, 95% <italic>CI</italic> = 1.02–1.93, <italic>p</italic> = 0.04) of lung cancer patients but non-significantly lower in males (<italic>OR</italic> = 0.84, 95% <italic>CI</italic> = 0.57–1.22, <italic>p</italic> =0.35) and among lung cancer patients at clinical stage I-II (<italic>OR</italic> = 0.95, 95% <italic>CI</italic> = 0.61–1.49, <italic>p</italic> = 0.82). The overall pooled estimates from <italic>C. pneumoniae</italic> studies revealed that <italic>C. pneumoniae</italic> infection is a risk factor among lung cancer patients who are IgA seropositive (<italic>OR</italic> = 1.88, 95% <italic>CI</italic> = 1.30–2.70, <italic>p</italic> < 0.001) and IgG seropositive (<italic>OR</italic> = 1.50, 95% <italic>CI</italic> = 1.10–2.04, <italic>p</italic> = 0.010). All seronegative IgA (<italic>OR</italic> = 0.69, 95% <italic>CI</italic> = 0.42–1.16, <italic>p</italic> = 0.16) and IgG (<italic>OR</italic> = 0.66, 95% <italic>CI</italic> = 0.42–105, <italic>p</italic> = 0.08) titers are not associative risk factors to lung cancer. </sec><sec> <title>Conclusions</title> Immunoglobulin (IgA) and IgG seropositive titers of <italic>C. pneumoniae</italic> and lungs infected with HPV types 16 and 18 are potential risk factors associated with lung cancer. </sec></abstract>

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Section: Discussionmentioning

confidence: 99%

Microbial infections as potential risk factors for lung cancer: Investigating the role of human papillomavirus and chlamydia pneumoniae

Drokow,

Effah,

Agboyibor

et al. 2023

AIMSPH

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“…Chlamydia pneumoniae (Cpn) is an obligate intracellular bacterium that causes various respiratory diseases in humans, including pneumonia [ 70 ]. Chronic obstructive pulmonary disease, asthma, and lung cancer may result from repeated or prolonged exposure to Chlamydia antigens [ 71 ].…”

Section: The Link Between Bacterial Infection and The Onset Of Cancermentioning

confidence: 99%

“…A systematic review of published articles was recently conducted on C. pneumoniae infection and the development of lung cancer. The authors of this study discovered that twenty-four articles describing one animal model positively supported the hypothesis, while three of the articles did not [ 70 ].…”

Section: The Link Between Bacterial Infection and The Onset Of Cancermentioning

confidence: 99%

Bacterial Infections and Cancer: Exploring This Association And Its Implications for Cancer Patients

Yusuf

Sampath

Umar

2023

IJMS

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Bacterial infections are common in the etiology of human diseases owing to the ubiquity of bacteria. Such infections promote the development of periodontal disease, bacterial pneumonia, typhoid, acute gastroenteritis, and diarrhea in susceptible hosts. These diseases may be resolved using antibiotics/antimicrobial therapy in some hosts. However, other hosts may be unable to eliminate the bacteria, allowing them to persist for long durations and significantly increasing the carrier's risk of developing cancer over time. Indeed, infectious pathogens are modifiable cancer risk factors, and through this comprehensive review, we highlight the complex relationship between bacterial infections and the development of several cancer types. For this review, searches were performed on the PubMed, Embase, and Web of Science databases encompassing the entirety of 2022. Based on our investigation, we found several critical associations, of which some are causative: Porphyromonas gingivalis and Fusobacterium nucleatum are associated with periodontal disease, Salmonella spp., Clostridium perfringens, Escherichia coli, Campylobacter spp., and Shigella are associated with gastroenteritis. Helicobacter pylori infection is implicated in the etiology of gastric cancer, and persistent Chlamydia infections present a risk factor for the development of cervical carcinoma, especially in patients with the human papillomavirus (HPV) coinfection. Salmonella typhi infections are linked with gallbladder cancer, and Chlamydia pneumoniae infection is implicated in lung cancer, etc. This knowledge helps identify the adaptation strategies used by bacteria to evade antibiotic/antimicrobial therapy. The article also sheds light on the role of antibiotics in cancer treatment, the consequences of their use, and strategies for limiting antibiotic resistance. Finally, the dual role of bacteria in cancer development as well as in cancer therapy is briefly discussed, as this is an area that may help to facilitate the development of novel microbe-based therapeutics as a means of securing improved outcomes.

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“…Similar to the concerns related to the evidence for various viruses as causes of lung cancer further investigations are needed to solidify the evidence for a causal role of Chlamydia in lung cancer [85].…”

Section: The Correlation Between Other Diseases Smoking and Lung Cancermentioning

confidence: 99%

The Epidemiology of Lung Cancer- How Much Have We Discovered?

Bagoury

Fahmy²

2022

JPRI

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Lung Cancer has become a global health burden in the past years due to being the second largest contributor to new cases and the high mortality rates worldwide which is around 1.8 million patients. There are two main histological groups of Lung Cancer, however non-small cell lung cancer is more prevalent and is composed of three histologic subtypes of which adenocarcinoma represents the highest prevalence. It is calculated that the incidence in male is higher than female. Cigarette smoking is the main risk factor for developing lung cancer, however, other risk factors contribute to the increasing cases. Studying the epidemiology of lung cancer is essential to establish robust surveillance system and establish policies to reduce this global concern. In this article we will review the epidemiological data, the history of the disease, and the associated risk factors.

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Chlamydia pneumoniae infections and development of lung cancer: systematic review

Cited by 13 publications

References 28 publications

Microbial infections as potential risk factors for lung cancer: Investigating the role of human papillomavirus and chlamydia pneumoniae

Microbial infections as potential risk factors for lung cancer: Investigating the role of human papillomavirus and chlamydia pneumoniae

Bacterial Infections and Cancer: Exploring This Association And Its Implications for Cancer Patients

The Epidemiology of Lung Cancer- How Much Have We Discovered?

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