An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

Chu, De-Jie; Guo, Sisi; Pan, Chunfeng; Wang, Jing; Du, Yong; Lu, Xufeng; Zhuyuan, YU

doi:10.7314/apjcp.2012.13.6.2819

Cited by 5 publications

(7 citation statements)

References 16 publications

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“…Kocazeybek et al (2003) reported that the titers of Cpn-IgA and Cpn-IgG in lung cancer patients could be higher than 1:40 and 1:512, respectively; they found a Cpn infection rate of 50.4% in general cases, which indicated that chronic Cpn infection enhanced the risk of lung cancer. Chu et al (2012) confirmed this opinion through the establishment of a lung cancer model by repeatedly infecting Wistar rats with Cpn. Although there is dispute regarding the relationship of Cpn infection and lung cancer, Cpn infection rate in patients with lung cancer is obviously higher than that of healthy people, and these patients benefit from the application of azithromycin.…”

Section: Discussionsupporting

confidence: 51%

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Azithromycin enhances the favorable results of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer

Chu¹,

Yao²,

Zhuang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT.Although new chemotherapeutic drugs have been applied constantly, their efficacy for non-small cell lung cancer (NSCLC) is still not satisfactory. In recent years, epidemiological investigations have shown that lung cancer may be induced by chronic Chlamydia pneumoniae (Cpn) infection, since stable high titers of Cpn antibodies, especially IgA, are a hallmark of chronic infections. Azithromycin is commonly used for the treatment of Cpn infections; however, there are only few reports regarding the application of azithromycin (A) combined with paclitaxel and cisplatin (TP) for advanced NSCLC. Considering that patients with NSCLC have a higher rate of Cpn infection, we proposed to employ azithromycin for Cpn infection in chemotherapy for advanced NSCLC. The aim of this study was to explore the effects of azithromycin on chemotherapy for NSCLC. A total of 86 patients with stage III-IV NSCLC were randomly divided into TP and ATP groups; the characteristics of patients in the two groups showed no significant differences. The TP group was treated with paclitaxel and cisplatin, and the ATP group was treated with Azithromycin, paclitaxel and cisplatin in lung cancer azithromycin combined with TP for at least 4 weeks, followed by evaluation and comparison of efficacy, side effects and patients' quality of life before and after chemotherapy between the two groups. Testing for Cpn infection revealed a significant difference in the case number before and after therapy in the ATP group (P < 0.01) compared with the TP group (P > 0.05), and a statistical difference was observed (P < 0.01) between the ATP and TP groups after treatment. The changes in quality of life of patients after two different chemotherapy regimens were statistically significant (P < 0.05), but there was a significant difference in only cognitive function after treatment. The changes in symptom scores of patients after the two different chemotherapy regimens were statistically significant (P < 0.05), but there was a significant difference in only shortness of breath and cough after treatment. Kaplan-Meier estimate was utilized to describe the survival function of patients in the two groups. The median survival time was 12.0 months for the TP group and 13.0 months for the ATP group. One-year survival rates of the TP and ATP groups were 45.0 and 75.0%, respectively, which were significantly different (P < 0.05). Our study of azithromycin+paclitaxe l+cisplatin on stage III-IV NSCLC patients achieved favorable results in terms of side effects and overall survival.

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Section: Discussionsupporting

confidence: 51%

“…In conclusion, Cpn infection is associated with an increased risk for lung cancer, and higher titers may be a better predictor of lung cancer risk. Earlier, we established a lung cancer model by repeatedly infecting Wistar rats with C. pneumoniae (Chu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Azithromycin enhances the favorable results of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer

Chu¹,

Yao²,

Zhuang³

et al. 2014

Genet. Mol. Res.

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“…Beside smoking, there are other potential genetic and environmental factors such as exposure to asbestos and radon definite metals, coal smoke, various hormones, and air pollution as well as genetic incompatibility and chronic infections of bacteria and parasites have been connected to lung carcinogenesis including C . Pneumoniae , [ 3 – 6 ]. The equivocal association of infectious agents in the etiology of cancer has focused the interest of scientists in recent year.…”

Section: Introductionmentioning

confidence: 99%

Systems Biology Approaches for the Prediction of Possible Role of Chlamydia pneumoniae Proteins in the Etiology of Lung Cancer

et al. 2016

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Accumulating evidence has recently supported the association of bacterial infection with the growth and development of cancers, particularly in organs that are constantly exposed to bacteria such as the lungs, colon, cervical cancer etc. Our in silico study on the proteome of Chlamydia pneumoniae suggests an unprecedented idea of the etiology of lung cancer and have revealed that the infection of C. pneumoniae is associated with lung cancer development and growth. It is reasonable to assume that C. pneumoniae transports its proteins within host-intracellular organelles during infection, where they may work with host-cell proteome. The current study was performed for the prediction of nuclear targeting protein of C. pneumoniae in the host cell using bioinformatics predictors including ExPASy pI/Mw tool, nuclear localization signal (NLS) mapper, balanced sub cellular localization predictor (BaCeILo), and Hum-mPLoc 2.0. We predicted 47/1112 nuclear-targeting proteins of C. pneumoniae connected with several possible alterations in host replication and transcription during intracellular infection. These nuclear-targeting proteins may direct to competitive interactions of host and C. pneumoniae proteins with the availability of same substrate and may be involved as etiological agents in the growth and development of lung cancer. These novel findings are expected to access in better understanding of lung cancer etiology and identifying molecular targets for therapy.

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“…Furthermore, cellular experiments also showed that Cpn infection could transform mesothelial cells, which in turn could increase lung cancer risk [ 25 ]. Researchers have also established a Cpn infection-induced lung cancer model in rats [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Combined and interaction effect of chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in Southeast China

Liu

Xiong³

et al. 2020

BMC Cancer

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Background This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Cpn infection, smoking, and various environmental factors. Methods The study comprised 449 lung cancer patients and 512 age- and sex-matched healthy controls. All participants provided a 5 ml fasting peripheral venous blood sample for testing Cpn-specific IgG and IgA by using micro-immunofluorescence. Besides analyzing the associations between Cpn and lung cancer, combined effect analysis, logistic regression, and the Excel table made by Andersson were used to analyze the combined and interaction effects of Cpn and environmental factors on lung cancer. Results Compared to those with no evidence of serum Cpn IgA or Cpn IgG, those with both Cpn IgG+ and IgA+ had 2.00 times the risk (95% CI: 1.34–3.00) of developing lung cancer. Cpn IgG+ or IgA+ was associated with a significantly increased risk of lung cancer among smokers; the adjusted odds ratio (OR) was 1.79 (95% CI: 1.10–2.91) and 2.27 (95% CI: 1.38–3.72), respectively. Those exposed to passive smoking with Cpn IgG+ or IgA+ also showed an increased risk of lung cancer; the adjusted OR was 1.82 (95% CI: 1.20–2.77) or 1.87 (95% CI: 1.22–2.87), respectively. Similar results were also observed among alcohol drinkers. Multiplicative and additive interactions were not observed between Cpn infection and environmental factors. The combined effects of Cpn IgG+ or IgA+ with smoking, passive smoking, and family history of cancer on lung cancer were determined. Conclusion Cpn infection is potentially associated with primary lung cancer in the Chinese Han population and has combined effects with smoking, passive smoking, and family history of cancer.

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An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

Cited by 5 publications

References 16 publications

Azithromycin enhances the favorable results of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer

Azithromycin enhances the favorable results of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer

Systems Biology Approaches for the Prediction of Possible Role of Chlamydia pneumoniae Proteins in the Etiology of Lung Cancer

Combined and interaction effect of chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in Southeast China

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