No evidence for mutagenic effects of ribavirin: report of two normal pregnancies

Crimean-Congo hemorrhagic fever treated with ribavirin in a pregnant woman

“…10 But there are some individual reports that no teratogenic effect was observed with ribavirin treatment in pregnancy. 11 In our case, the patient was at the 36th week of her gestation, and she had a severe disease. The baby had almost completed intrauterine maturation.…”

Ribavirin and pegylated interferon treatment for hepatitis C was associated not only with semen alterations but also with sperm deoxyribonucleic acid fragmentation in humans

“…After the recommended period of contraception a pregnancy occurred and resulted in delivery of a healthy girl. In humans, only 22 pregnancies during or within 3 months of male ribavirin exposure have been reported in four studies (37)(38)(39)(40). Seven pregnancy outcomes were unknown, but 33.3% of known outcomes were miscarriages.…”

The Ribavirin Pregnancy Registry: An Interim Analysis of Potential Teratogenicity at the Mid-Point of Enrollment

“…Data on human pregnancy exposures to ribavirin are limited. Single case reports and case series have been published that describe both normal pregnancies, resulting in healthy babies coincident with maternal and paternal exposure to ribavirin, and adverse pregnancy outcomes including spontaneous and induced abortions [20][21][22][23][24][25]. No birth defects have been reported except in the setting of concomitant teratogen exposure [24].…”