Ribavirin and pegylated interferon treatment for hepatitis C was associated not only with semen alterations but also with sperm deoxyribonucleic acid fragmentation in humans

Pecou, Stephane; Moinard, Nathalie; Walschaerts, Marie; Pasquier, Christophe; Daudin, Myriam; Bujan, Louis

doi:10.1016/j.fertnstert.2008.07.1755

Cited by 45 publications

(39 citation statements)

References 36 publications

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“…Samples were collected by masturbation in our laboratory after a mean sexual abstinence duration of 4.1 AE 0.1 days. After liquefaction (37 C for 30 minutes), semen analysis was performed as previously published (14,39). Briefly, semen volume was measured by a graduated pipette and the pH measured with reaction paper.…”

Section: Semen Samplingmentioning

confidence: 99%

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Mild induced testicular and epididymal hyperthermia alters sperm chromatin integrity in men

Ahmad

Moinard

Esquerré-Lamare

et al. 2012

Fertility and Sterility

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Section: Semen Samplingmentioning

confidence: 99%

“…Sperm DFI and high DNA stainability (HDS) were measured by conventional sperm chromatin structure assay (SCSA) techniques (35,40) routinely used in our laboratory (14,39). Briefly, a fraction of semen sample containing a minimum of 4 Â 10 6 spermatozoa was separated from the original sample.…”

Section: Sperm Chromatin Structure Assaymentioning

confidence: 99%

Mild induced testicular and epididymal hyperthermia alters sperm chromatin integrity in men

Ahmad

Moinard

Esquerré-Lamare

et al. 2012

Fertility and Sterility

Self Cite

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“…Herbal medicines such as Syosaikoto are recommended for use after a six-month washout period. In addition, a recent study demonstrated that the fragmentation of sperm deoxyribonucleic acid induced by peginterferon and ribavirin persisted for eight months after the end of treatment [9]. Therefore, a washout period of six months or longer may be advisable before starting UDCA administration.…”

Section: Discussionmentioning

confidence: 99%

Ursodeoxycholic acid exacerbates peginterferon-induced interstitial pneumonia in a patient with hepatitis C

Kaneko

Ogawa

Iwata

et al. 2009

Clin J Gastroenterol

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Pegylated interferon alpha combined with ribavirin is currently the standard treatment for hepatitis C virus (HCV) infection. Ursodeoxycholic acid (UDCA) is used as a complementary treatment in patients who are non-responders or who develop severe side effects of this combined therapy. UDCA is generally considered to be a relatively safe drug. However, we recently encountered a patient with chronic hepatitis C in whom interferon-induced interstitial pneumonia was exacerbated by UDCA. This patient responded to initial antiviral therapy with non-pegylated interferon alpha-2b and ribavirin, but hepatitis recurred soon after the end of treatment. A second course of antiviral therapy using peginterferon alpha-2b and ribavirin achieved normalization of serum transaminases and HCV-RNA, but also caused interstitial pneumonia. After discontinuing peginterferon, this side effect was ameliorated. On the other hand, hepatitis relapsed four months later. UDCA treatment was started and serum transaminase levels decreased, but exacerbation of interstitial pneumonia occurred with marked elevation of the serum KL-6 level. To our knowledge, this is the first reported case of peginterferon-induced interstitial pneumonia showing exacerbation due to UDCA therapy.

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“…Therefore, Ribavirin is absolutely contraindicated for both HCVinfected childbearing women and HCV-infected male partners of pregnant women unless they take effective contraceptive measures. In addition, since Ribavirininduced spermatogenic abnormalities (cell toxicity, mutagenicity and a decreased epididymal sperm count) reverted only 4-8 mo after treatment withdrawal in all animal species studied [29,30] , women are advised to avoid pregnancy for at least 6 mo after partners of men taking Ribavirin treatment [26,27] .…”

Section: The Past Of Antiviral Therapy: Peg-ifn/ribavirin and Peg-ifnmentioning

confidence: 99%

Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women?

Spera

Eldin

Tosone

et al. 2016

WJH

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population, with the highest prevalence in individuals under 40. The prevalence in pregnant women varies with geographical distribution (highest in developing countries). Prevalence also increases in sub-populations of women at high risk for blood-transmitted infections. HCV infection in pregnancy represents a non-negligible problem. However, most of the past antiviral regimens cannot be routinely offered to pregnant or breastfeeding women because of their side effects. We briefly reviewed the issue of treatment of HCV infection in pregnant/breastfeeding women focusing on the effects of the new direct-acting antivirals on fertility, pregnancy and lactation in animal studies and on the potential risk for humans based on the pharmacokinetic properties of each drug. Currently, all new therapy regimens are contraindicated in this setting because of lack of sufficient safety information and adequate measures of contraception are still routinely recommended for female patients of childbearing potential. Core tip: Until recently, the only drugs available for the treatment of hepatitis C virus infection had a welldocumented teratogenic effect limiting their use in childbearing women. Recently, new generation drugs, designated the direct-acting antivirals have been approved. There are no studies available describing their effects on pregnant and lactating women. We here will try to analyze their pharmacokinetic properties and data from animal studies to try to predict their potential use pregnancy.Spera AM, Kamal Eldin T, Tosone G, Orlando R. Antiviral therapy for hepatitis C: Has anything changed for pregnant/ Anna Maria Spera, Tarek Kamal Eldin, Grazia Tosone, Raffaele Orlando Anna Maria Spera, Tarek Kamal Eldin, Grazia Tosone, Raffaele Orlando, Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples Federico II, 80131 Napoli, ItalyAuthor contributions: Spera AM designed and wrote the review; Kamal Eldin T analyzed pharmacological and clinical data; Tosone G and Orlando R overview the manuscript.Conflict-of-interest statement: All authors declare any conflicting interests (including but not limited to commercial, personal, political, intellectual or religious interests). In addition, reviewers have not potential conflicting interests related to any particular paper they maybe are asked to review.

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Ribavirin and pegylated interferon treatment for hepatitis C was associated not only with semen alterations but also with sperm deoxyribonucleic acid fragmentation in humans

Cited by 45 publications

References 36 publications

Mild induced testicular and epididymal hyperthermia alters sperm chromatin integrity in men

Mild induced testicular and epididymal hyperthermia alters sperm chromatin integrity in men

Ursodeoxycholic acid exacerbates peginterferon-induced interstitial pneumonia in a patient with hepatitis C

Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women?

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