No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome

Abstract

BackgroundSingle nucleotide polymorphisms (SNP) in the promoter region of the interleukin (IL)-10 genes have a role in determining hepatitis B virus (HBV) outcome.ObjectivesThis study evaluates the correlation between HBV infection and SNP in IL-10 gene promoter.Patients and MethodsNinety-six HBV-infected patients (32 chronic hepatitis B infection patients, 34 healthy carriers, 30 spontaneously recovered cases) and 31 healthy controls were enrolled. Three biallelic (-819,-592,-1082) regions in the IL-10 gene promoter were sequenced for all patients.ResultsGenotypes and haplotypes of IL-10 gene promoter region at position -1082, -819 and -592 were not significantly different among controls, HBV recovered cases, carriers and chronic HBV patients. Nevertheless, A/A genotype at position -592 and T/T genotype at position -819 were more frequently seen in the HBV clearance group, while frequency of G/G genotype at position -1082 was more prevalent in the persistence group. GCC/GCC and GCC/ACC haplotypes were significantly observed in anti-HBe positive individuals.ConclusionsOur findings showed that IL-10 promoter polymorphisms were not correlated with HBV infection prognosis. Nevertheless, individuals carrying high and intermediate producer of IL-10 haplotypes had a better ability to develop anti-HBe than low producer carriers.

Association between cytokine gene polymorphisms and outcome of hepatitis B virus infection in southern Brazil

“…This seemed to corroborate previous studies performed in China showing an increased frequency of the AA genotype in subjects with viral clearance [Wang et al, ] and an association of the GG genotype to chronicity [Xiang et al, ]. However, the difference of genotype frequencies observed here was not statistically significant, and divergent findings have also been reported [Cheong et al, ; Sofian et al, ]. The real influence of the IL10‐592C/A polymorphism on the outcome of HBV infection has to be confirmed.…”

Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis

“…IL-10 genetic variants are associated with higher IL-10 production (Turner et al, 1997;Suarez et al, 2003;López et al, 2010;Sofian et al, 2013). Sofian et al (2013) reported that IL-10 promoter polymorphisms were not associated with HBV infection, and the A/A genotype at position -592 and the T/T genotype at position -819 were more frequently observed in patients with HBV.…”

“…IL-10 genetic variants are associated with higher IL-10 production (Turner et al, 1997;Suarez et al, 2003;López et al, 2010;Sofian et al, 2013). Sofian et al (2013) reported that IL-10 promoter polymorphisms were not associated with HBV infection, and the A/A genotype at position -592 and the T/T genotype at position -819 were more frequently observed in patients with HBV. Moreover, IL-10 mRNA polymorphisms are associated with hepatocellular carcinoma, particularly in HBV-and HCVinfected individuals (Shin et al, 2003;Wang et al, 2006;Yang et al, 2011;Wei et al, 2011).…”

There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment

“…Controversial results have been observed in the majority of studies that have compared genotype distributions of polymorphisms of the IL-10 gene promoter with fibrosis severity (12) (14) (15) . Jin et al (14) investigated the role of IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G gene polymorphisms in the development of liver cirrhosis in Asian populations, demonstrating that the IL-10-592 A/C gene polymorphism enhances the risk of liver cirrhosis, and that this gene variant interacts with chronic hepatitis B infection in this population.…”

“…On the other hand, Sofi an et al (15) studied 96 patients infected with the hepatitis B virus (HBV) from a reference center for hepatitis in Central Iran, as well as and 31 healthy controls from a blood transfusion organization. The authors sought to evaluate the correlation between HBV and polymorphism (-G1082A) IL-10.…”