No. 292-Abnormal Uterine Bleeding in Pre-Menopausal Women

A Review of Clinical Guidelines on the Management of Iron Deficiency and Iron-Deficiency Anemia in Women with Heavy Menstrual Bleeding

“…Most guidelines (15/22) included guidance on screening women with HMB for anemia (Table 2) [4,5,[50][51][52][53][54][55][56][57][58][59][60][61][62]. However, the guidance varied with respect to the universal use of screening versus criteria-led testing, identifying relevant symptoms, and diagnostic Hb level.…”

“…However, the guidance varied with respect to the universal use of screening versus criteria-led testing, identifying relevant symptoms, and diagnostic Hb level. Thirteen guidelines recommended routine initial assessment of Hb levels or a full blood count for all women presenting with HMB [4,5,[50][51][52][53][54][55][56][57][58][59][60]. Two further guidelines recommended routine assessment of Hb or a full blood count for women with HMB who also met specific criteria-namely an appropriate medical history and/or bleeding score [61], or the presence of physical or psychological symptoms indicative of ID/IDA [62].…”

“…Of the 15 guidelines that recommended quantification of Hb or a full blood count, only four specified a threshold Hb level indicative of anemia (\ 12 g/ dL [5,51,57] and \ 10 g/dL [50], respectively). Although six of the guidelines recommended evaluating symptoms of ID/IDA/anemia during the initial assessment [50-52, 56, 61, 62], only four of these described the specific signs and symptoms of anemia or ID/IDA to check for in the patient [50,51,56,62]. In these four guidelines, pallor [50,51], shortness of breath with or without activity [50,56], and lightheadedness/dizziness [50,56,62] were the most commonly stated signs and symptoms.…”

Label-Free Proteomic Analysis Uncovers SMC1A Expression is Down-regulated in AUB-E Patients

“…While AUB is a prevalent symptom among women seeking gynecologic care, endometrial function in the context of menstruation and its disorders is still not fully understood [16]. For the present, the diagnosis of AUB-E depends on careful history taking and exclusion of other contributors [4,17].…”

Outpatient uterine assessment and treatment unit in patients with abnormal uterine bleeding: an economic modelling study

“…The care represents general gynecology practice guided by the Society of Obstetricians and Gynaecologists of Canada guideline. 22 In the usual care branch of our model, management includes the patient's initial consultation followed by further assessments (tests, imaging, repeat visits and surgery, if indicated) until diagnosis and treatment has been reached based on the experiences of the 200 women included in the chart review.…”