A Review of Clinical Guidelines on the Management of Iron Deficiency and Iron-Deficiency Anemia in Women with Heavy Menstrual Bleeding

Mansour, Diana; Hofmann, Axel; Gemzell‐Danielsson, Kristina

doi:10.1007/s12325-020-01564-y

Cited by 84 publications

(65 citation statements)

References 74 publications

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“…On the other hand, no difference was found between the daily zinc intake of women in the premenopause and postmenopausal groups. However, all women should be supported in dietary terms for iron and zinc (40).…”

Section: Discussionmentioning

confidence: 99%

The relationship between nutritional status, anthropometric measurements and hemogram parameters in preobese and obese women before and after menopause

Özçeli̇k

Karaman

Tanoğlu

et al. 2021

Journal of Health Sciences and Medicine

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Objective: The nutritional status of pre-obese and obese women in the premenopausal and postmenopausal period is thought to be associated with anemia. In this study, we aimed to reveal the extent to which they meet their daily energy and nutrient needs and the relationship with the development of anemia by examining the food consumption records of women in the premenopausal and postmenopausal periods. Material and Method: Women who applied to the Ataşehir District Health Directorate Healthy Nutrition and Active Life Unit for "Nutrition and Diet Consultancy" between May-July 2019 were included in the study. Women were divided into two groups as premenopause (36-45 years old) and postmenopause (46-73 years old) and their anthropometric measurements and nutritional status were evaluated. Serum glucose, blood urea nitrogen (BUN), creatinine, total-cholesterol, triglyceride, HDL, LDL, AST, ALT, iron, iron binding capacity, ferritin, vitamin B12, TSH, free T4, vitamin D and hemogram parameters of all participants were recorded. Results: The waist circumference of 67.5% of the women in the premenopause group and 75% of the women in the postmenopausal group were above 88 cm. The blood BUN and HDL levels of premenopausal women were found to be lower than those in the postmenopausal period (BUN: 10.6±3.51 versus 15.06±4.96 and HDL: 54.1±9.1 versus 59, respectively. 3±13.5; p <0.05). Premenopausal women had lower blood ferritin levels and higher iron binding capacity (WBC) compared to postmenopausal women (Ferritin: 15.8±11.5 versus 33.5±25.4 and DBT: 311.12±61.7 vs 287.50±41.93; p <0.05). One of the important results of the study was the higher levels for vitamin D, AST and ALT in women in the post-menopausal period (p <0.05). Conclusion:It was determined that women in the premenopausal period did not receive enough iron and vitamin D to meet their needs. For this reason, daily food consumption should be adjusted accordingly, and lifestyle changes should be made to acquire healthy eating habits.

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Section: Discussionmentioning

confidence: 99%

The relationship between nutritional status, anthropometric measurements and hemogram parameters in preobese and obese women before and after menopause

Özçeli̇k

Karaman

Tanoğlu

et al. 2021

Journal of Health Sciences and Medicine

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“…Heavy blood loss from menstruation is a potential contributor to iron deficiency anemia [ 8 ]. Defined as a blood loss of ~80 mL during one menstrual cycle [ 9 ], studies have shown that heavy menstrual bleeding affects ~18–38% of women of reproductive age [ 10 ]. However, the proportion of women thought to experience heavy menstrual bleeding is likely even higher due to underdiagnosis [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Defined as a blood loss of ~80 mL during one menstrual cycle [ 9 ], studies have shown that heavy menstrual bleeding affects ~18–38% of women of reproductive age [ 10 ]. However, the proportion of women thought to experience heavy menstrual bleeding is likely even higher due to underdiagnosis [ 10 ]. Prolonged heavy menstrual blood may lead to decreased iron stores in women, especially if women are not consuming a sufficient amount of dietary iron [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Iron-Containing Oral Contraceptives and Their Effect on Hemoglobin and Biomarkers of Iron Status: A Narrative Review

2021

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Oral contraceptive use has been associated with decreased menstrual blood losses; thus, can independently reduce the risk of anemia and iron deficiency in women. Manufacturers have recently started to include supplemental iron in the non-hormonal placebo tablets of some contraceptives. The aims of this narrative review are: (i) to describe the relationship between oral contraceptive use and both anemia and iron status in women; (ii) to describe the current formulations of iron-containing oral contraceptives (ICOC) available on the market; and (iii) to systematically review the existing literature on the effect of ICOC on biomarkers of anemia and iron status in women. We discovered 21 brands of ICOC, most commonly including 25 mg elemental iron as ferrous fumarate, for seven days, per monthly tablet package. Our search identified one randomized trial evaluating the effectiveness of ICOC use compared to two non-ICOC on increasing hemoglobin (Hb) and iron status biomarker concentrations in women; whereafter 12 months of contraception use, there were no significant differences in Hb concentration nor markers of iron status between the groups. ICOC has the potential to be a cost-effective solution to address both family planning needs and iron deficiency anemia. Yet, more rigorous trials evaluating the effectiveness of ICOC on improving markers of anemia and iron deficiency, as well as investigating the safety of its consumption among iron-replete populations, are warranted.

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“…Acute and chronic blood loss might not only be surrogates of yet undiagnosed diseased which require further workup but also might be considered as an illness itself which requires haemostasis management (8,9). In emergency patients with acute blood loss, fast assessment of a multitude of blood components, a.o.…”

Section: Introductionmentioning

confidence: 99%

“…The technique has been successfully applied to evaluate tumor characteristics non-invasively (4). While several studies showed the bene ts of radiomics in solid tissue and predominantly cancer research (5-7), its potential to assess owing structures and moving tissues has not yet been investigated.Acute and chronic blood loss might not only be surrogates of yet undiagnosed diseased which require further workup but also might be considered as an illness itself which requires haemostasis management (8,9). In emergency patients with acute blood loss, fast assessment of a multitude of blood components, a.o.…”

mentioning

confidence: 99%

Potential of High Dimensional Radiomic Features to Assess Flowing Blood Components in Non-contrast CT Scans

Mahmoudi¹,

Martin²,

Ackermann³

et al. 2021

Preprint

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Background: To assess the potential of radiomic features to quantify components of flowing blood to non-invasively predict moderate-to-severe anemia in non-contrast enhanced CT scans. Methods: One hundred patients (median age, 69 years; range, 19–94 years) who received CT scans of the thoracolumbar spine and blood-testing for hemoglobin and hematocrit levels ± 24h between 08/2018 and 11/2019 were retrospectively included. Intraaortic blood was segmented using a spherical volume of interest with consecutive radiomic analysis. Feature selection was performed applying analysis of correlation and collinearity. The final feature set was obtained to differentiate moderate-to-severe anemia. Random forest machine learning was applied and predictive performance was assessed. A decision-tree was obtained to propose a cut-off value of CT Hounsfield units (HU).Results: High correlation with hemoglobin and hematocrit levels was shown for first-order radiomic features (p<0.001 to p=0.032). The top 3 features showed high correlation to hemoglobin values (p) and minimal collinearity (r) to the top ranked feature Median (p<0.001), Energy (p=0.002, r=0.387), Minimum (p=0.032, r=0.437). Median (p<0.001) and Minimum (p=0.003) differed in moderate-to-severe anemia compared to non-anemic state. Median yielded superiority to the combination of Median and Minimum (p(AUC)=0.015, p(precision)=0.017, p(accuracy)=0.612) in the predictive performance employing random forest analysis. A Median HU value ≤ 36.5 indicated moderate-to-severe anemia (accuracy=0.90, precision=0.80).Conclusions: First-order radiomic features correlate with hemoglobin levels and may be feasible for the prediction of moderate-to-severe anemia. High dimensional radiomic features did not inherit the potential to augment the data in our exemplary use case of flowing blood component assessment.Trial registration: Retrospectively registered.

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A Review of Clinical Guidelines on the Management of Iron Deficiency and Iron-Deficiency Anemia in Women with Heavy Menstrual Bleeding

Cited by 84 publications

References 74 publications

The relationship between nutritional status, anthropometric measurements and hemogram parameters in preobese and obese women before and after menopause

The relationship between nutritional status, anthropometric measurements and hemogram parameters in preobese and obese women before and after menopause

Iron-Containing Oral Contraceptives and Their Effect on Hemoglobin and Biomarkers of Iron Status: A Narrative Review

Potential of High Dimensional Radiomic Features to Assess Flowing Blood Components in Non-contrast CT Scans

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