NMR techniques in drug delivery: Application to zein protein complexes

Sousa, Francisco Fábio Oliveira de; Luzardo-Álvarez, Asteria; Blanco-Méndez, J.; Martín-Pastor, Manuel

doi:10.1016/j.ijpharm.2012.09.046

Cited by 43 publications

(24 citation statements)

References 46 publications

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“…In the development of drug delivery systems, the release behavior is a key factor in establishing their applicability. 21 Formulations containing only zein and T4OL released 55.9% of the drug in 7 h (Figure 3). Oleic acid-based NPs exhibited higher release values compared with those that contained limonene (36.5% vs. 27.9% in 7 h).…”

Section: Resultsmentioning

confidence: 99%

“…21 Thus, the objective of this study was to optimize a biodegradable and biocompatible nanostructured system for the local delivery of T4OL. Because the skin has natural protection against the penetration of external media, 22 skin penetration enhancers (SPEs) were also added to the formulations to evaluate their effect on the physicochemical properties and in vitro release of T4OL.…”

Section: Introductionmentioning

confidence: 99%

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Biodegradable Nanoparticles Obtained From Zein as a Drug Delivery System for Terpinen-4-Ol

Marini¹,

Martelli²,

Zornio³

et al. 2014

Química Nova

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Biodegradable nanoparticles (NPs) have received considerable attention because of their possible use in the development of strategies for the topical delivery of oils and therapeutic drugs, particularly when drug penetration in dermis is desired. Zein is a prolamine and is a promising material for the design of drug delivery systems. In this study, NPs were prepared with zein and were used to encapsulate and release terpinen-4-ol, which is a therapeutic agent for the treatment of melanoma. The results show that the zein NPs are promising nanostructured systems for the prolonged delivery of T4OL with potential applications in anti-melanoma therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanoparticles Obtained From Zein as a Drug Delivery System for Terpinen-4-Ol

Marini¹,

Martelli²,

Zornio³

et al. 2014

Química Nova

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“…In addition, zein is an amphiphilic protein with an important ability to interact with solutes like drugs [32] or amino acids [33]. Moreover, zein displays mucoadhesive properties [12] and a relatively high resistance to the effect of digestive enzymes [3].…”

Section: Discussionmentioning

confidence: 99%

Zein nanoparticles for oral folic acid delivery

Peñalva

Esparza

González-Navarro

et al. 2015

Journal of Drug Delivery Science and Technology

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“…Zein is a major plant-based storage protein rich in prolamine found in the endosperm of the corn kernel [35]. It is a by-product from the processing of maize corn present in corn gluten meal and from the manufacturing of ethanol during the wet and dry milling processes [36].…”

Section: Protein Materialsmentioning

confidence: 99%

“…All zein fractions have hydrophobic and hydrophilic domains but zein is frequently considered to be a hydrophobic protein due to its insolubility in water and solubility in ethanol, acetone, and acetylacetone. The non-polar helical interiors of the zein protein have glutamine-rich turns and loops that allow it to self-assemble into particles and layers [35]. With successive helical segment folding in an antiparallel arrangement, zein can exhibit chemical and thermoplastic properties that are heat and pH stable [37].…”

Section: Protein Materialsmentioning

confidence: 99%

Protein-Based Drug-Delivery Materials

et al. 2017

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There is a pressing need for long-term, controlled drug release for sustained treatment of chronic or persistent medical conditions and diseases. Guided drug delivery is difficult because therapeutic compounds need to survive numerous transport barriers and binding targets throughout the body. Nanoscale protein-based polymers are increasingly used for drug and vaccine delivery to cross these biological barriers and through blood circulation to their molecular site of action. Protein-based polymers compared to synthetic polymers have the advantages of good biocompatibility, biodegradability, environmental sustainability, cost effectiveness and availability. This review addresses the sources of protein-based polymers, compares the similarity and differences, and highlights characteristic properties and functionality of these protein materials for sustained and controlled drug release. Targeted drug delivery using highly functional multicomponent protein composites to guide active drugs to the site of interest will also be discussed. A systematical elucidation of drug-delivery efficiency in the case of molecular weight, particle size, shape, morphology, and porosity of materials will then be demonstrated to achieve increased drug absorption. Finally, several important biomedical applications of protein-based materials with drug-delivery function—including bone healing, antibiotic release, wound healing, and corneal regeneration, as well as diabetes, neuroinflammation and cancer treatments—are summarized at the end of this review.

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NMR techniques in drug delivery: Application to zein protein complexes

Cited by 43 publications

References 46 publications

Biodegradable Nanoparticles Obtained From Zein as a Drug Delivery System for Terpinen-4-Ol

Biodegradable Nanoparticles Obtained From Zein as a Drug Delivery System for Terpinen-4-Ol

Zein nanoparticles for oral folic acid delivery

Protein-Based Drug-Delivery Materials

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