Zein nanoparticles for oral folic acid delivery

Peñalva, Rebeca; Esparza, Irene; González-Navarro, Carlos J.; Quincoces, Gemma; Peñuelas, Iván; Irache, Juan M.

doi:10.1016/j.jddst.2015.06.012

Cited by 83 publications

(40 citation statements)

References 39 publications

(49 reference statements)

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“…Zein nanoparticles help protect the folic acid from the gastric environment, where free folic acid can precipitate, and act as folic acid carriers for the absorptive membrane of the intestine. The properties of zein would be responsible for an increase in the lifetime of folic acid in the upper gastrointestinal tract, where its absorption is favored (Peñalva et al, 2015).…”

Section: Functional Groupsmentioning

confidence: 99%

“…Torres-Giner, Martinez-Abad, Ocio, and Lagaron (2010) produced zein capsules by an electrospraying process with docosahexaenoic acid (DHA, Omega-3) and reported the delay of oxidation reactions and an increase in chemical stability of the DHA. Peñalva et al (2015), in a study using zein to encapsulate folic acid by spray-drying for pharmaceutical applications, evaluated the ability of zein nanoparticles to improve the bioavailability of folic acid. However, there are no studies on the evaluation of the thermal resistance of folic acid encapsulated with zein by electrospraying or electrospinning at temperatures simulating the processing of food for application in the food industry.…”

Section: Introductionmentioning

confidence: 99%

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Thermal and irradiation resistance of folic acid encapsulated in zein ultrafine fibers or nanocapsules produced by electrospinning and electrospraying

Evangelho

Crizel

Chaves

et al. 2019

Food Research International

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The objectives of this study were to characterize zein fibers and capsules prepared by electrospinning and electrospraying techniques, respectively, and then use them to encapsulate folic acid. Folic acid containing fibers and capsules (0.5, 1.0, and 1.5%, w/v) were submitted to thermal treatment (100, 140, and 180°C) and ultraviolet A light (UVA) irradiation to evaluate the resistance of folic acid. Zein fibers and capsules containing folic acid showed high encapsulation efficiency (> 80%). Unencapsulated folic acid showed a reduction in folic acid content from 17.17 μg/mL to 5.44 μg/mL (approximately 70%) when exposed to 180°C. Photodegradation of unencapsulated folic acid lowered its concentration from 17.17 μg/mL to 12.58 μg/mL (~26% of reduction), when exposed for 1 h to UVA irradiation. However, folic acid concentration when encapsulated in fibers (1.5%) was maintained or only slightly reduced from 9.73 μg/mg to 8.88 μg/mg after thermal treatment at 180°C. The capsules containing 1.5% of folic acid also presented a slight reduction in folic acid concentration from 8.84 μg/ mg to 7.88 μg/mg when exposed to 24 h of UVA irradiation. Zein fibers and capsules containing folic acid present promising characteristics for application in foods that require thermal processing or exposure to irradiation.

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Section: Functional Groupsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thermal and irradiation resistance of folic acid encapsulated in zein ultrafine fibers or nanocapsules produced by electrospinning and electrospraying

Evangelho

Crizel

Chaves

et al. 2019

Food Research International

View full text Add to dashboard Cite

show abstract

“…Bioactivity and bioavailability enhancement through encapsulation of zein protein particles has also been achieved with other nutraceuticals such as i) resveratrol, it was shown that encapsulated resveratrol had stronger antioxidant and anticancer activity than free resveratrol . ii) Folic acid, the encapsulation of folic acid resulted in improved pharmacokinetics (Figure b) and a twofold increase in its oral bioavailability . This was attributed to the muco‐adhesive properties of zein particles that reach the small intestine and develop muco‐adhesive interactions.…”

Section: Emerging Application Of Functional and Engineered Food Colloidsmentioning

confidence: 90%

“…A) Number of citations to scientific articles published per year with the search words “delivery system” and “food” (Web of Science, Thomson Scientific); B) folic acid serum concentration versus time after a single oral administration of 1 mg kg −1 for folic acid solution (FA sol) and folic acid loaded in zein nanoparticles (FA‐NP‐Z); C) naringenin in phosphate buffer (1.1 ×10 −3 m , pH 6.9, 2% ethanol v/v), without β‐lg (left) and with 0.54 ×10 −3 m β‐lg (right); D) SEM micrographs of spray‐dried Bifidobacterium longum microcapsules; and E) SEM images of whey protein particle prepared by two‐step emulsification and heat‐induced gelation at neutral pH . All panels are reproduced with permission . Copyright 2013, 2014, 2015, 2018, Elsevier.…”

Section: Emerging Application Of Functional and Engineered Food Colloidsmentioning

confidence: 99%

Functional and Engineered Colloids from Edible Materials for Emerging Applications in Designing the Food of the Future

Patel

2018

Adv Funct Materials

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Functional and engineered colloids fabricated from edible materials have recently gained a lot of interest for futuristic applications in the field of foods for purposes ranging from microstructure development to delivery of healthpromoting bioactives to manipulation of food-body interactions. This review tackles a very ambitious task of discussing the current understanding of functional colloids within the framework of foods. Physicochemical attributes of several novel complex colloids fabricated from natural, and often, underutilized edible materials are clearly and comprehensively reviewed in this paper. This review not only provides a scientific insight into the advances made in the field of colloid-based food structuring but also touches on the exciting future opportunities in this promising multidisciplinary field.

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“…The antisolvent precipitation method, which is a common method to fabricate the nano-particles suspension, can achieve this goal. Based on the previous literature, the nano particles of zein have been used to deliver the bioactive compounds, such as resveratrol and folic acid (Peñalva et al, 2015;Rebeca et al, 2015). As a shell, zein colloidal was applied for encapsulating peppermint oil, Vitamin D3, and green tea catechins, etc.…”

Section: Introductionmentioning

confidence: 99%

Modification of the physicochemical and structural characteristics of zein suspension by dielectric barrier discharge cold plasma treatment

Jin

et al. 2020

Journal of Food Science

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Owing to the strong hydrophobicity of zein, improved solubility is required to enhance the recovery of bioactive peptides. Using a zein suspension prepared by the antisolvent precipitation method, the impact of varying the voltage during dielectric barrier discharge (DBD) treatment on the physicochemical and conformational properties of zein in water was investigated. Analysis of the particle size, specific surface area, and free sulfhydryl content indicated that the protein solubility was maximized by treatment at 70 V for 70 s. DBD treatment destroyed covalent bonds and introduced some hydrophilic groups onto the zein surface, thus enhancing the contact area with water molecules and leading to a more uniform dispersion. A decrease in the hydrodynamic radius of zein micelles indicated that intermolecular interactions were disrupted, thus improving dispersion stability. A more hydrophilic microenvironment was formed owing to the reduction in hydrophobic interactions. Additionally, evaluation of the secondary structure demonstrated that DBD treatment broke hydrogen bonds, resulting in a loose conformation with more exposed sites of action for water. These results are expected to facilitate the development of technologies for improving utilization of zein. Practical Application Strong hydrophobicity limits the application of zein in the food industry. The study indicated that DBD treatment could promote loose structure, and improve dispersion stability and hydrophilicity of zein suspension prepared by antisolvent precipitation method. This work revealed the potential of cold plasma treatment for modifying zein and other insoluble proteins, which would expand their scope of application.

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Zein nanoparticles for oral folic acid delivery

Cited by 83 publications

References 39 publications

Thermal and irradiation resistance of folic acid encapsulated in zein ultrafine fibers or nanocapsules produced by electrospinning and electrospraying

Thermal and irradiation resistance of folic acid encapsulated in zein ultrafine fibers or nanocapsules produced by electrospinning and electrospraying

Functional and Engineered Colloids from Edible Materials for Emerging Applications in Designing the Food of the Future

Modification of the physicochemical and structural characteristics of zein suspension by dielectric barrier discharge cold plasma treatment

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