NLRP3 RNAi of Injected Synoviocytes Inhibits the Inflammatory Responses in Articular Cavity and Alleviates the Injury of Articular Cartilage in a Rabbit Model

Zhang, Hua; Yang, Junfeng; Zhou, Bengen; Chen, Jianfa; Li, Jie; Li, Qihuo; Xiong, Hao; Liu, Fuyifei

doi:10.1166/jbt.2018.1837

Cited by 2 publications

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“…P300 is a large histone acetyltransferase that regulates various DNA-binding transcription factors [26]. According to Skikama et al, P300 is necessary to develop a cardiac valvular septal structure and coronary vascular system [27].…”

Section: Discussionmentioning

confidence: 99%

A Detailed Study to Discover the Trade between Left Atrial Blood Flow, Expression of Calcium-Activated Potassium Channels and Valvular Atrial Fibrillation

Shen

Ferdous

Wang

et al. 2022

Cells

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Background: The present study aimed to explore the correlation between calcium-activated potassium channels, left atrial flow field mechanics, valvular atrial fibrillation (VAF), and thrombosis. The process of transforming mechanical signals into biological signals has been revealed, which offers new insights into the study of VAF. Methods: Computational fluid dynamics simulations use numeric analysis and algorithms to compute flow parameters, including turbulent shear stress (TSS) and wall pressure in the left atrium (LA). Real-time PCR and western blotting were used to detect the mRNA and protein expression of IKCa2.3/3.1, ATK1, and P300 in the left atrial tissue of 90 patients. Results: In the valvular disease group, the TSS and wall ressure in the LA increased, the wall pressure increased in turn in all disease groups, mainly near the mitral valve and the posterior portion of the LA, the increase in TSS was the most significant in each group near the mitral valve, and the middle and lower part of the back of the LA and the mRNA expression and protein expression levels of IKCa2.3/3.1, AKT1, and P300 increased (p < 0.05) (n = 15). The present study was preliminarily conducted to elucidate whether there might be a certain correlation between IKCa2.3 and LA hemodynamic changes. Conclusions: The TSS and wall pressure changes in the LA are correlated with the upregulation of mRNA and protein expression of IKCa2.3/3.1, AKT1, and P300.

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Section: Discussionmentioning

confidence: 99%

A Detailed Study to Discover the Trade between Left Atrial Blood Flow, Expression of Calcium-Activated Potassium Channels and Valvular Atrial Fibrillation

Shen

Ferdous

Wang

et al. 2022

Cells

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“…These substances can kill or inhibit bacterial growth, lowering the risk of infection. A study utilized photocured hydrogels to repair bone defects and successfully embedded silver nanoparticles with antibacterial activity within them [13]. The results demonstrated that silver nanoparticles effectively inhibited bacterial infections and biofilm formation, thereby enhancing the treatment of bone defects.…”

Section: Drug Delivery and Antibacterial Propertiesmentioning

confidence: 99%

Application of photocured hydrogels in the treatment of bone defect diseases

Liu,

Pei,

Lin

et al. 2023

TNS

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Photocured hydrogels are materials with great potential, offering a novel approach in the treatment of bone defects. They exhibit excellent biocompatibility, tunable degradation characteristics, and the ability to incorporate cells and growth factors. This paper explores the mechanisms and advantages of photocured hydrogel applications in the treatment of bone defects, focusing on bone formation promotion, drug-loading and antimicrobial properties, and enhancement of vascularization in the surrounding tissues. Research indicates that photocured hydrogels can serve as scaffolds, drug delivery systems, and tissue engineering materials, promoting bone cell proliferation, osteogenic differentiation, inhibiting bone resorption and osteolysis, fostering vascularization, and providing drug-loading antimicrobial effects. Nevertheless, the application of photocured hydrogels in the treatment of bone defect diseases faces challenges, such as long-term stability and interface adaptability. Further research and development are required to overcome these challenges, facilitating the widespread clinical use of photocured hydrogels and improving the treatment outcomes and quality of life for patients with bone defects.

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NLRP3 RNAi of Injected Synoviocytes Inhibits the Inflammatory Responses in Articular Cavity and Alleviates the Injury of Articular Cartilage in a Rabbit Model

Cited by 2 publications

References 0 publications

A Detailed Study to Discover the Trade between Left Atrial Blood Flow, Expression of Calcium-Activated Potassium Channels and Valvular Atrial Fibrillation

A Detailed Study to Discover the Trade between Left Atrial Blood Flow, Expression of Calcium-Activated Potassium Channels and Valvular Atrial Fibrillation

Application of photocured hydrogels in the treatment of bone defect diseases

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