Application of photocured hydrogels in the treatment of bone defect diseases

Abstract

Photocured hydrogels are materials with great potential, offering a novel approach in the treatment of bone defects. They exhibit excellent biocompatibility, tunable degradation characteristics, and the ability to incorporate cells and growth factors. This paper explores the mechanisms and advantages of photocured hydrogel applications in the treatment of bone defects, focusing on bone formation promotion, drug-loading and antimicrobial properties, and enhancement of vascularization in the surrounding tissues. Research indicates that photocured hydrogels can serve as scaffolds, drug delivery systems, and tissue engineering materials, promoting bone cell proliferation, osteogenic differentiation, inhibiting bone resorption and osteolysis, fostering vascularization, and providing drug-loading antimicrobial effects. Nevertheless, the application of photocured hydrogels in the treatment of bone defect diseases faces challenges, such as long-term stability and interface adaptability. Further research and development are required to overcome these challenges, facilitating the widespread clinical use of photocured hydrogels and improving the treatment outcomes and quality of life for patients with bone defects.