Nitrous oxide reduces the cost of intravenous anaesthesia

Heath, K. J.; Sadler, P.; Winn, J. H.; McFadzean, William

doi:10.1097/00003643-199607000-00011

Cited by 14 publications

(13 citation statements)

References 7 publications

(2 reference statements)

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“…Katoh and Ikeda found that the addition of 63.5% nitrous oxide allowed a reduction of the sevoflurane MAC by 61% (7). It has also been shown that nitrous oxide decreases the need for intravenous anaesthetics (4). Our finding that the sevoflurane consumption decreased by about 60% in this clinical setting is therefore not very surprising.…”

Section: Discussionsupporting

confidence: 66%

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The sevoflurane‐sparing effect of nitrous oxide: a clinical study

Jakobsson

Heidvall

Davidson

1999

Acta Anaesthesiol Scand

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Section: Discussionsupporting

confidence: 66%

“…The cost-benefit ratio of anaesthetics is becoming an increasingly important factor in the choice of anaesthetic technique (4,5). We found that nitrous oxide decreased the consumption of sevoflurane by about 60%.…”

Section: Discussionmentioning

confidence: 81%

The sevoflurane‐sparing effect of nitrous oxide: a clinical study

Jakobsson

Heidvall

Davidson

1999

Acta Anaesthesiol Scand

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“…Propofol has been used for total intravenous anaesthesia because of its favourable pharmacokinetic profile [1]. Nitrous oxide reduces the dose of propofol required for the induction and maintenance of anaesthesia [2, 3]. This co‐administration can reduce the cost of anaesthesia [3].…”

mentioning

confidence: 99%

Effects of nitrous oxide on haemodynamic and electroencephalographic responses induced by tetanic electrical stimulation during propofol anaesthesia

Inada¹,

Shingu²,

Nakao³

et al. 1999

Anaesthesia

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SummaryWe studied the effect of nitrous oxide on haemodynamic and electroencephalographic responses caused by noxious stimulation during propofol anaesthesia. Thirty-four patients (ASA I-II) were anaesthetised with propofol 3 mg.kg ¹1 and were randomly allocated to receive either 60% nitrous oxide in oxygen or 40% oxygen in air. Anaesthesia was maintained using propofol infusion of 10 mg.kg ¹1 .h ¹1 for the first 10 min, 8 mg.kg ¹1 .h ¹1 for the next 10 min and 6 mg.kg ¹1 .h ¹1 thereafter. Thirty minutes after the induction of anaesthesia, tetanic electrical stimulation (80 mA, 100 Hz) was applied to the ulnar nerve. Tetanic stimulation significantly increased blood pressure and heart rate in both groups (p < 0.005 or less), but did not induce any arousal pattern on the electroencephalograph. Nitrous oxide significantly attenuated the tetanic stimulation-induced increase in blood pressure (p < 0.05 or less), but not the heart rate.

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“…Both techniques significantly reduce the consumption of anaesthetics and must be standardised within a study design. 26,27 To assess whether there is a true difference in resource use, other than acquisition costs, between different agents it is necessary to obtain accurate information on resource use for the anaesthetic and postanaesthetic periods. Costing the anaesthetic period is complicated, since most operating theatre management systems have no information about the cost of providing general anaesthesia.…”

Section: Economic Evidencementioning

confidence: 99%

Which anaesthetic agents are cost-effective in day surgery? Literature review, national survey of practice and randomised controlled trial

Elliott

Payne

Moore

et al. 2002

Health Technol Assess

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Nitrous oxide reduces the cost of intravenous anaesthesia

Cited by 14 publications

References 7 publications

The sevoflurane‐sparing effect of nitrous oxide: a clinical study

The sevoflurane‐sparing effect of nitrous oxide: a clinical study

Effects of nitrous oxide on haemodynamic and electroencephalographic responses induced by tetanic electrical stimulation during propofol anaesthesia

Which anaesthetic agents are cost-effective in day surgery? Literature review, national survey of practice and randomised controlled trial

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