Nitroimidazole derivative incorporated liposomes for hypoxia-triggered drug delivery and enhanced therapeutic efficacy in patient-derived tumor xenografts

Li, Yi; Lu, Ailing; Long, Mengmeng; Cui, Lei; Chen, Zhongping; Zhu, Li

doi:10.1016/j.actbio.2018.10.029

Cited by 82 publications

(43 citation statements)

References 59 publications

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“…To overcome these obstacles, nanoscale drug delivery systems (DDSs) have attracted more and more attention and been extensively investigated (Chen et al, 2014), such as polymeric micelles (PMs), nanoparticles (NPs), prodrug, and liposome (Zhang et al, 2016;Zylberberg & Matosevic, 2016;Huang et al, 2018;Li et al, 2018;Dong et al, 2019). These effective DDSs are used to deliver hydrophobic or hydrophilic therapeutics which exhibit poor pharmacokinetics and high cytotoxicity to the site of tumor (Wang et al, 2016;Qin et al, 2017;Li et al, 2019). Recently, multilayered liposome-polymer NPs prepared by layer-bylayer (LbL) deposition technique appear as the more promising nano-sized carriers for targeted drug delivery and controlled release (Ariga et al, 2014;Borges & Mano, 2014;Sakr et al, 2016;Olszyna et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

et al. 2020

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In this work, a pH-sensitive liposome-polymer nanoparticle (NP) composed of lipid, hyaluronic acid (HA) and poly(b-amino ester) (PBAE) was prepared using layer-by-layer (LbL) method for doxorubicin (DOX) targeted delivery and controlled release to enhance the cancer treatment efficacy. The NP with pH-sensitivity and targeting effect was successfully prepared by validation of charge reversal and increase of hydrodynamic diameter after each deposition of functional layer. We further showed the DOX-loaded NP had higher drug loading capacity, suitable particle size, spherical morphology, good uniformity, and high serum stability for drug delivery. We confirmed that the drug release profile was triggered by low pH with sustained release manner in vitro. Confocal microscopy research demonstrated that the NP was able to effectively target and deliver DOX into human non-small cell lung carcinoma (A549) cells in comparison to free DOX. Moreover, the blank NP showed negligible cytotoxicity, and the DOX-loaded NP could efficiently induce the apoptosis of A549 cells as well as free DOX. Notably, in vivo experiment results showed that the DOX-loaded NPs effectively inhibited the growth of tumor, enhanced the survival of tumor-bearing mice and improved the therapeutic efficacy with reduced side-effect comparing with free drug. Therefore, the NP could be a potential intelligent anticancer drug delivery carrier for cancer chemotherapy, and the LbL method might be a useful strategy to prepare multi-functional platform for drug delivery.

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Section: Introductionmentioning

confidence: 99%

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

et al. 2020

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“…Nanotechnology has been widely investigated for the diagnosis and treatment of diseases, especially for cancer. Ultrasound microbubbles, 1 lipid nanoparticles, 2,3 liposomes, 4 polymer micelles, 5–7 mesoporous silica nanoparticles, 8–10 mesoporous carbon nanoparticles, 11,12 metal oxide nanoparticles, 13–16 and so on have been studied. The conventional nanoscale preparation can be passively ingested into the vascular endothelial space of the tumor and transmits the chemotherapeutic drugs to the tumor tissue.…”

Section: Introductionmentioning

confidence: 99%

Preparation of paclitaxel-folic acid functionalized gelatin grafted mesoporous hollow carbon nanospheres for enhancing antitumor effects toward liver cancer (SMMC-7721) cell lines

Gao

Liu

et al. 2019

J Biomater Appl

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Folic acid functionalized gelatin-coated mesoporous hollow carbon nanospheres (FGMCN) were synthesized and applied to enhance the antitumor curative effect of paclitaxel (PTX) for human liver cancer cell lines (SMMC-7721). PTX was loaded in FGMCN by the adsorption method and the PTX-loaded samples (PTX-FGMCN) had a drug content of 29.8 ± 1.06%. The PTX-FGMCN with a sustained release effect was characterized by X-ray diffraction and differential scanning calorimeter in order to analyze the PTX state in FGMCN. In vitro cell experiments showed that FMHSN improves the uptake of PTX and promotes apoptosis due to the nano-targeting effect of FMHSN. An in vivo tumor bearing experiment in mice indicated that the PTX-FGMCN significantly inhibited the growth of tumors. All of these results suggested that the PTX-FGMCN may be an effective anti-hepatoma drug in the future.

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“…Their usage is already well established, and recent efforts are focused on enhancing their selectivity, which is typically completed by using pH-sensitive systems, modifying the materials with cancer-specific molecules, [72] (A); Schematic representation of the different types of liposomes [67] (B); Schematic representation of liposome-based drug delivery system for cancer therapy [68] (C); Schematic illustration for triggered release of hypoxia-responsive liposomal drug delivery system (D) [196] or introducing additional molecules that can combat the chemoresistance. Some studies combine all three approaches.…”

Section: Liposomesmentioning

confidence: 99%

Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

Benko¹

2020

CDR

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Cancer is one of the biggest healthcare concerns in our century, a disease whose treatment has become even more difficult following reports of drug-resistant tumors. When this happens, chemotherapy treatments fail or decrease in efficiency, leading to catastrophic consequences to the patient. This discovery, along with the fact that drug resistance limits the efficacy of current treatments, has led to a new wave of discovery for new methods of treatment. The use of nanomedicine has been widely studied in current years as a way to effectively fight drug resistance in cancer. Research in the area of cancer nanotechnology over the past decades has led to tremendous advancement in the synthesis of tailored nanoparticles with targeting ligands that can successfully attach to chemotherapy-resistant cancer by preferentially accumulating within the tumor region through means of active and passive targeting. Consequently, these approaches can reduce the off-target accumulation of their payload and lead to reduced cytotoxicity and better targeting. This review explores some categories of nanocarriers that have been used in the treatment of drug-resistant cancers, including polymeric, viral, lipid-based, metal-based, carbon-based, and magnetic nanocarriers, opening the door for an exciting field of discovery that holds tremendous promise in the treatment of these tumors.

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Nitroimidazole derivative incorporated liposomes for hypoxia-triggered drug delivery and enhanced therapeutic efficacy in patient-derived tumor xenografts

Cited by 82 publications

References 59 publications

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

Preparation of paclitaxel-folic acid functionalized gelatin grafted mesoporous hollow carbon nanospheres for enhancing antitumor effects toward liver cancer (SMMC-7721) cell lines

Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

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