Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

Abstract

Cancer is one of the biggest healthcare concerns in our century, a disease whose treatment has become even more difficult following reports of drug-resistant tumors. When this happens, chemotherapy treatments fail or decrease in efficiency, leading to catastrophic consequences to the patient. This discovery, along with the fact that drug resistance limits the efficacy of current treatments, has led to a new wave of discovery for new methods of treatment. The use of nanomedicine has been widely studied in current years as a way to effectively fight drug resistance in cancer. Research in the area of cancer nanotechnology over the past decades has led to tremendous advancement in the synthesis of tailored nanoparticles with targeting ligands that can successfully attach to chemotherapy-resistant cancer by preferentially accumulating within the tumor region through means of active and passive targeting. Consequently, these approaches can reduce the off-target accumulation of their payload and lead to reduced cytotoxicity and better targeting. This review explores some categories of nanocarriers that have been used in the treatment of drug-resistant cancers, including polymeric, viral, lipid-based, metal-based, carbon-based, and magnetic nanocarriers, opening the door for an exciting field of discovery that holds tremendous promise in the treatment of these tumors.

Niosomes in cancer treatment: A focus on curcumin encapsulation

“…Various therapeutic moiety delivery technologies for cancer chemotherapy have been investigated and analysed. There are multiple difficulties in cancer treatment, such as non-targeted delivery, short drug release profiles, and drug resistance tumor interactions [ 18 ]. Hence, cancer treatment techniques vary to support the efficiency and effectiveness of treatments targeting cancer cells.…”

“…Despite accessible formulations and an abundance of drugs, cancer treatment remains a major challenge for researchers. One of the primary challenges in developing and curating innovative drug delivery systems for targeting cancer cells is in improving the cancer cell elimination efficiency while retaining sufficient systematic biocompatibility in vivo [ 18 ] . In the context of using niosomes as the delivery system for curcumin for cancer treatments, the influences of parameters such as the niosome formulation, pH condition, membrane surface charge, nature of the surfactant, and temperature of the dispersion medium remain unclear.…”

Nanodelivery systems: An efficient and target‐specific approach for drug‐resistant cancers

“…Interestingly, Guo et al used magnetic particles to obtain high resolution and contrast imaging of malignancies 143 . These therapies make the cancer cells more receptive to additional therapies, allowing for the efficient delivery of higher therapeutic agent doses while reducing the possibility of unfavorable side effects 145 …”

“… 143 These therapies make the cancer cells more receptive to additional therapies, allowing for the efficient delivery of higher therapeutic agent doses while reducing the possibility of unfavorable side effects. 145 …”

Anticancer Potential of Temozolomide-Loaded Eudragit-Chitosan Coated Selenium Nanoparticles: In Vitro Evaluation of Cytotoxicity, Apoptosis and Gene Regulation

“…Several strategies have been proposed to overcome resistance to cancer chemotherapies. Nanocarriers have the potential to limit drug toxicity, achieve tumor localization, and overcome drug resistance [ 18 , 19 ]. On the other hand, brain drug delivery and passing the blood–brain barrier (BBB) are directly affected by particle size.…”