Nitrofurazone‐loaded PVA–PEG semi‐IPN for application as hydrogel dressing for normal and burn wounds

Abstract

Hydrogels have been used in a wide variety of biomedical devises, particularly in the field of drug delivery, tissue engineering, and wound healing. In this study, a polyvinyl alcohol (PVA)–polyethylene glycol (PEG) semi‐interpenetrating hydrogel network (IPN)‐based wound dressing system containing nitrofurazone (NFZ) was synthesized by chemical crosslinking technique. The introduction of PEG to PVA matrix led to reduction in the water vapor transmission rate, which in‐turn resulted in improved healing activity. Drug‐loaded IPNs were prepared by mixing aqueous solution of NFZ with the optimized PVA–PEG formulation subsequent to the crosslinking step. The in vitro diffusion studies of NFZ indicated a relatively slow release of drug resulting from its microencapsulation in the polymeric matrix. Subsequently, in vivo wound healing efficacy toward acute and burn wound healing in experimental rats was investigated. Semi‐IPN hydrogel loaded with NFZ dressing improved the overall healing rate in both acute and burn wounds, as evidenced by significant increase in total protein, hydroxyproline and hexosamine contents. Histological examinations also correlated well with the biochemical findings. A faster wound contraction was also observed in hydrogel treated acute and burn wounds. The results indicated that PVA–PEG semi‐IPN hydrogel based dressing systems containing NFZ could be used as an effective wound dressing material. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

Nitrofurazone-loaded electrospun PLLA/sericin-based dual-layer fiber mats for wound dressing applications

“…50) and the cumulative release percentage of NFZ at various times was determined based on the calibration curve (eqn (3)) which obtained from different concentrations of NFZ from 0.0001 to 0.01 mg mL À1 in PBS (pH 7.4). The test solution was replenished with 1.0 mL fresh PBS.…”

“…41,42 Sericin is a good biomaterial because of its specic functional properties such as biocompatibility, antioxidant, moisture absorption, antibacterial, UV resistance and biodegradability. 50 The drug release proles could be controlled by adjusting the drug amount in the PLLA/sericin blend ber layer and pure PLLA ber layer. Moreover, an electrospun three-dimensional PCL/ sericin porous nanobrous scaffold was produced and the hydrophilic capability increased with the sericin addition, which improved human primary skin broblast cells adhesion and proliferation on the scaffolds.…”

Mechanical properties and drug release rate of poly(vinyl alcohol)/poly(ethylene glycol)/clay nanocomposite hydrogels: Correlation with structure and physical properties

“…The cumulative mass percentage‐time curves for the drug (curcumin) released in distilled water from the hydrogels with the various amounts of the nanoclay are shown in Figure . Although the pH of chronic wounds could be in the range from 5.5 to 8, the drug‐releasing behavior of the hydrogel samples with the application for healing normal wounds were usually evaluated in a neutral environment such as distilled water applied in this research. Moreover, it should be noted that as reported by other researchers, the PVA hydrogels are not so sensitive to pH stimuli and a treatment is necessary to obtain the pH sensitive PVA hydrogels …”

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

“…It is well established that, wound healing requires certain ideal conditions, such as a suitable microenvironment (free of pathogenic microorganisms), inflammation control (dosage control 2 drug control) 10 that can be accomplished through the use of nontoxic polymeric materials with low immunogenicity. These materials can favor the partial pressure of oxygen, 11 which helps to improve revascularization, migration, and replication of fibroblasts, in addition increases the rate of collagen production. 12 Polymer systems in the form of semi-interpenetrating polymer networks (semi-IPNs) are composed of at least one chemically crosslinked polymer network and a linear polymer (uncrosslinked).…”