Nitric oxide and iron: effect of iron overload on nitric oxide production in endotoxemia

Galleano, Mónica; Simontacchi, Marcela; Puntarulo, Susana

doi:10.1016/j.mam.2004.02.015

Cited by 53 publications

(28 citation statements)

References 73 publications

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“…OGG1 activity is inhibited by an inflammatory process that was shown to be produced in response to the administration of a high iron dose in rats. 54 In this study, piglets supplemented with a single high dose of FeDex were found to be particularly prone to unbalanced DNA repair activity. Since the differences in the repair rate of the two studied enzymes were smaller following a split dose of iron, this modified supplementation protocol may be beneficial.…”

Section: Discussionmentioning

confidence: 77%

Benefits and Risks of Iron Supplementation in Anemic Neonatal Pigs

Lipiński¹,

Starzyński²,

Canonne‐Hergaux³

et al. 2010

The American Journal of Pathology

126

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Iron deficiency is a common health problem. The most severe consequence of this disorder is iron deficiency anemia (IDA), which is considered the most common nutritional deficiency worldwide. Newborn piglets are an ideal model to explore the multifaceted etiology of IDA in mammals, as IDA is the most prevalent deficiency disorder throughout the early postnatal period in this species and frequently develops into a critical illness. Here, we report the very low expression of duodenal iron transporters in pigs during the first days of life. We postulate that this low expression level is why the iron demands of the piglet body are not met by iron absorption during this period. Interestingly, we found that a low level of duodenal divalent metal transporter 1 and ferroportin, two iron transporters located on the apical and basolateral membrane of duodenal absorptive enterocytes, respectively, correlates with abnormally high expression of hepcidin, despite the poor hepatic and overall iron status of these animals. Parenteral iron supplementation by a unique intramuscular administration of large amounts of iron dextran is current practice for the treatment of IDA in piglets. However, the potential toxicity of such supplemental iron implies the necessity for caution when applying this treatment. Here we demonstrate that a modified strategy for iron supplementation of newborn piglets with iron dextran improves the piglets' hematological status, attenuates the induction of hepcidin expression, and minimizes the toxicity of the administered iron. (Am J Pathol

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Section: Discussionmentioning

confidence: 77%

Benefits and Risks of Iron Supplementation in Anemic Neonatal Pigs

Lipiński¹,

Starzyński²,

Canonne‐Hergaux³

et al. 2010

The American Journal of Pathology

126

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“…In addition, increased lipid peroxidation during liver damage was reported (29,30,36). It has been demonstrated that imbalance between oxidant and antioxidant factors, occurred in the iron overload condition, which resulted in reduction of enzyme activity such as catalase (31,34). In the current study, iron overload resulted in various adverse effects, such as increase in ALT, AST, and ALP activity and MDA level, as well as decreased CAT activity, which indicates liver damage.…”

Section: Discussionmentioning

confidence: 53%

“…Treatment of experimental animals with iron-dextran, similar to hemochromatosis, resulted in, iron loaded anemia (34). In order to exclude the probability of iron chelation before adsorption or direct hindrance of absorption by extract in the intestine, it was preferred to use IP injection of iron dextran for iron-overload induction.…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, iron overload resulted in various adverse effects, such as increase in ALT, AST, and ALP activity and MDA level, as well as decreased CAT activity, which indicates liver damage. These changes may be the result of the production of ROS and oxidative damage by hepatic iron accumulation, which, finally, may result in chronic diseases (30) and leakage of cellular enzymes into the circulation due to increased liver membrane permeability (31,34). However, after treatment with hydro-alcoholic extract of C. sativum, reduction of theses liver biomarkers was observed.…”

Section: Discussionmentioning

confidence: 99%

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The Protective Effects of Hydro-Alcoholic Extract of Coriandrum sativum in Rats with Experimental Iron-Overload Condition

Talaei

Kheirollah

Babaahmadi‐Rezaei

et al. 2017

Jundishapur J Nat Pharm Prod

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Background: Development of a new iron-chelating medication may eventually serve as treatment of iron overload diseases, such as thalassemia and other iron related disorders. Coriander sativum, a plant rich of phenol and flavonoids, has an iron-chelating effect in-vitro. The ethanolic extract of C. sativum was investigated for its in-vivo ameliorating effect on hepatic damage in rats with experimental iron overload. Methods: Twenty-four adult male wistar rats were randomly divided to 4 groups: healthy control, iron overload, iron overload treated with deferoxamine, and 200 mg/kg of C. sativum extract, respectively. Assessments were performed for serum iron, ferritin, and serum markers of hepatic and cardiac damages, antioxidant enzyme, and lipid peroxidation levels. Results:The results indicated serum iron and ferritin concentration were significantly increased in the iron overload group compared to healthy controls (P < 0.05). Treatment with C. sativum extract significantly decreased iron and ferritin concentration (P < 0.05). Histopathological changes in the liver, kidney, and the cardiac system, and iron accumulation in the liver were observed in the iron overload group compared to healthy controls (P < 0.05). Treatment with C. sativum extract significantly decreased biochemical parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and Creatinine phosphokinase (CPK), and improved tissue damage and decreased iron accumulation in the liver compared to the iron overload group (P < 0.05). Conclusions:The study showed that the hydro-alcoholic extract of C. sativum has iron-chelating and liver protective effects similar to deferoxamine against experimental iron overload condition in rats.

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“…Several mechanisms has been proposed whereby excess hepatic Fe causes cellular injury, but Fe-induced peroxidative injury to phospholipids of organelle membranes is a potential unifying mechanisms underlying the major theories of cellular injury in Fe overload [49]. With progressively increasing Fe deposition, the capacity to maintain Fe in storage forms is exceeded resulting in a transient increase in the hepatic LIP [50]. Moreover, Fe-catalyzed generation of ROS has been implicated in the pathogenesis of many disorders including atherosclerosis [51,52], cancer [53], ischaemia reperfusion injury [54,55] besides in Fe overload [56], such as haemochromatosis [57].…”

Section: Fe Overload In Mammalsmentioning

confidence: 99%