The Protective Effects of Hydro-Alcoholic Extract of Coriandrum sativum in Rats with Experimental Iron-Overload Condition

Talaei, Rahman; Kheirollah, Alireza; Babaahmadi‐Rezaei, Hossein; Mansouri, Esrafil; Mohammadzadeh, Ghorban

doi:10.5812/jjnpp.65028

Cited by 6 publications

(2 citation statements)

References 36 publications

(45 reference statements)

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“…The iron content was also notably higher in fresh as well as dried leaves, and also in the extracts prepared by using the soxhlet extraction method, indicating the leaves of C. sativum and P. crispum are significant iron sources. On the other hand, the extracts of coriander leaves showed an effective chelating nature with iron [ 31 ], indicating the iron metabolism can be influenced by coriander leaves, whereas parsley leaves are proved to have components involved in the treatment of anxiety and depression [ 32 ]. The nanoparticles produced from the parsley leaves may be used effectively against iron deficiency, anemia condition, in rats [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Efficiency of Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) in Enhancing Iron Absorption: An In Silico and In Vitro Approach

Sangeetha

Ibrahim²,

Deepa³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) are the common herbs used for culinary purposes in daily life. The chlorophyll pigment in plants is being identified with various medicinal values, whereas iron is an essential micronutrient for the proper metabolism of the human body. The current research has been aimed at predicting the role of C. sativum and P. crispum in enhancing iron absorption via an in vitro approach. C. sativum and P. crispum have been analyzed for their capability of being a source of chlorophyll and iron concentration. The extracts prepared from solvents like carbinol, petroleum ether, and water were subjected to the identification of phytoconstituents through gas chromatography-mass spectrometry analysis, and the identified compounds were subjected to in silico studies against the iron-binding receptor, transferrin, to depict the binding affinity of the identified compounds. The carbinol extract was then put through in vitro analytical studies in Caco2 cell lines with a concentration of 500 µg/ml. Current research has shown that the leaves of C. sativum and P. crispum are an excellent source of chlorophyll and iron and has also suggested that these herbs efficiently enhance the absorption of iron in human intestinal cells.

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Section: Discussionmentioning

confidence: 99%

Efficiency of Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) in Enhancing Iron Absorption: An In Silico and In Vitro Approach

Sangeetha

Ibrahim²,

Deepa³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, inhibition of lipid peroxidation is considered one of the major strategies for treating hepatic damage under iron overload conditions 31 .…”

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confidence: 99%

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2022

IJPSR

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Iron overload has toxic effects on the body. Hepatotoxicity is a common finding in iron-overloaded patients, resulting from iron deposition in hepatocytes. Angiotensinɪɪ is involved in developing hepatic damage through its prooxidative properties. Therefore, the current study aimed to investigate the therapeutic effect of the ACE inhibitor, lisinopril, against ferrous sulfate-induced hepatic functional disorders and histological damages in rats, due to its inhibitory effect on angiotensin II and its ability to scavenge free radicals in-vitro. 23 male adult rats were randomly classified into three groups and treated as follows: Normal control group: received daily 1 ml/day distilled water as an intraperitoneal injection for 14 days, Iron overload non-treated group: received ferrous sulfate at a daily dose of 30 mg/kg/day i.p. for 14 days, Iron overload treated with lisinopril group: received ferrous sulfate at a dose of 30 mg/kg/day followed by lisinopril at a dose of 1 mg/kg/day daily i.p. for 14 days. Compared to the control group, administration of ferrous sulfate resulted in liver dysfunction, as evidenced by significantly higher serum hepatic markers levels, increased malondialdehyde levels, and histological damages. Treatment with lisinopril significantly reversed the elevated serum hepatic enzyme levels and lipid peroxidation marker in the liver. All these changes were corroborated by histological observations of the liver (P<0.05). Our study suggests that lisinoprilprotects against iron overload-induced hepatotoxicity through inhibition of lipid peroxidation.

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Hepatic Response to the Interaction Between Thymoquinone and Iron-Dextran: an In Vitro and In Vivo Study

Ghasemi

Ghaffari

Omidifar

et al. 2022

Biol Trace Elem Res

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The Protective Effects of Hydro-Alcoholic Extract of Coriandrum sativum in Rats with Experimental Iron-Overload Condition

Cited by 6 publications

References 36 publications

Efficiency of Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) in Enhancing Iron Absorption: An In Silico and In Vitro Approach

Efficiency of Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) in Enhancing Iron Absorption: An In Silico and In Vitro Approach

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Hepatic Response to the Interaction Between Thymoquinone and Iron-Dextran: an In Vitro and In Vivo Study

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