Efficiency of Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) in Enhancing Iron Absorption: An In Silico and In Vitro Approach

Abstract

Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) are the common herbs used for culinary purposes in daily life. The chlorophyll pigment in plants is being identified with various medicinal values, whereas iron is an essential micronutrient for the proper metabolism of the human body. The current research has been aimed at predicting the role of C. sativum and P. crispum in enhancing iron absorption via an in vitro approach. C. sativum and P. crispum have been analyzed for their capability of being a source of chlorophyll and iron concentration. The extracts prepared from solvents like carbinol, petroleum ether, and water were subjected to the identification of phytoconstituents through gas chromatography-mass spectrometry analysis, and the identified compounds were subjected to in silico studies against the iron-binding receptor, transferrin, to depict the binding affinity of the identified compounds. The carbinol extract was then put through in vitro analytical studies in Caco2 cell lines with a concentration of 500 µg/ml. Current research has shown that the leaves of C. sativum and P. crispum are an excellent source of chlorophyll and iron and has also suggested that these herbs efficiently enhance the absorption of iron in human intestinal cells.

Petroselinum Crispum (Mill.) Fuss (Parsley), a Food and Medicinally Important Plant: A Review of Recent Studies Between 2013-2023

“…No cytotoxicity was detected in ethanol, methanol, and aqueous extract [101]. It was determined that the carbinol extract of P. crispum seeds at different concentrations (62.5-1000 μl) did not show toxicity in Caco-2 cells by MTT assay [64].…”

“…The extract enabled 8.24% of the iron applied to Caco-2 cells to be absorbed by the cells and showed lower permeability (2.01×10 7 cm/s). It was concluded that parsley is a good of chlorophyll and iron and increases the absorption of iron from human intestinal cells [64].…”