NIR photothermal therapy using polyaniline nanoparticles

Zhou, Jing; Lü, Zhengliang; Zhu, Xingjun; Wang, Xuejiao; Liao, Yi; Ma, Zhanfang; Li, Fuyou

doi:10.1016/j.biomaterials.2013.08.075

Cited by 342 publications

(257 citation statements)

References 43 publications

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“…Promising results with these nanoparticles were obtained in our laboratory for in vivo assays with apoptosis and necrosis as the responsible mechanisms of cell death (Ibarra et al 2013). Previous studies of polyaniline nanoparticles in PTT showed similar results in different cancer cell lines (Yang et al 2011;Zhou et al 2013). Apparently, the uptakes of both PANINps and the laser dosage are the controlling factors for thermally induced cytotoxicity.…”

Section: Laser Treatment Of Tumor Cells With Pani-npssupporting

confidence: 50%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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Polyaniline nanoparticles (PANI-Nps) have been used in several applications; however, there are few publications related to the use in the photothermal therapy. PANI-Nps have high optical absorbance in the near-infrared region and in this wavelength range, biological systems are relatively transparent. For this reason, these materials can be used to absorb energy and to generate heat that destroys cancer cells selectively. PANI-Nps with average size of ca. 200 nm and neutral zeta potential were synthesized and characterized by DLS, SEM, and zeta potential. The kinetics of incorporation of PANINps into LM2 cell line was monitored using UV-Vis spectrophotometry. The analysis of cell viability after PANI-Nps exposure shows that these nanoparticles are not cytotoxic even at high concentration and show no change in cell morphology and metabolic activity. Furthermore, we found that nanoparticle cell uptake reaches the maximum value c.a. 3 h after incubation. Cells were targeted by Pani-Nps and irradiated, resulting in significant elevation of intracellular ROS and heat production. One of the mechanisms of PANINps-mediated photothermal killing of cancer cells apparently involved oxidative stress resulting in apoptotic cell death.

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Section: Laser Treatment Of Tumor Cells With Pani-npssupporting

confidence: 50%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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“…In vivo photothermal imaging was performed with an FLIR E40 equipment, in conjunction with an 808 nm laser illuminator, which were set up by Zhou et al 30 NU/NU nude mice bearing tumor were anesthetized (with 10% chloral hydrate, 100 µL), and PBS solution of UCNPs-PANPs (50 µL, 1 mg mL…”

Section: Photothermal Imaging In Vivomentioning

confidence: 99%

“…According to the equations, the η value for the UCNPs-PANPs was determined as 47.8% ( Figure 4D and E), which is quite similar to that of previously reported PANPs. 30 The photostability of the UCNP-PANP solution was also studied using a photothermal imaging system. The temperatures of the UCNPs-PANPs remained at the same level after five cycles of NIR laser-induced heating (808 nm laser at 1.20 W cm −2 , 2 minutes laser irradiation for each cycle; Figure 4F).…”

Section: Photothermal Conversion Efficiency Of Ucnps-panpsmentioning

confidence: 99%

“…For bioapplications, UCNPs-PANPs were further capped with F127 according to a previous study. 30 Zeta potential and hydrodynamic diameter were also measured. The zeta potential of the UCNPs-PANPs was ~0 and dynamic light scattering measurements showed that the effective hydrodynamic diameter of the UCNPs-PANPs was ~120 nm ( Figure S1).…”

Section: Photothermal Conversion Efficiency Of Ucnps-panpsmentioning

confidence: 99%

“…For bioapplication, UCNPsPANPs were further capped with F127 according to the previous literature. 30 …”

Section: Synthesis Of Ucnps-panpsmentioning

confidence: 99%

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Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy

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et al. 2016

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In this study, we developed a nanosystem based on upconversion nanoparticles (UCNPs) coated with a layer of polyaniline nanoparticles (PANPs). The UCNP induces upconversion luminescence for imaging and photothermal conversion properties are due to PANPs. In vitro experiments showed that the UCNPs-PANPs were nontoxic to cells even at a high concentration (800 µg mL −1 ). Blood analysis and histological experiments demonstrated that the UCNPs-PANPs exhibited no apparent toxicity in mice in vivo. Besides their efficacy in photothermal cancer cell ablation, the UCNP-PANP nanosystem was found to achieve an effective in vivo tumor ablation effect after irradiation using an 808 nm laser. These results demonstrate the potential of the hybrid nanocomposites for use in imaging-guided photothermal therapy.

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Conducting Polymers

Uribe

Palma-Cando

2022

Kirk-Othmer Encyclopedia of Chemical Technology

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This article gives valuable information about the history and the different families, synthesis, and characteristics of the most used conducting polymers, namely, polyphenylenes, polypyrroles, polythiophenes, poly(arylene‐vinylenes), polyanilines, and polycarbazoles, and diverse conducting polymers (liquid crystalline conducting polymers (LCCPs), conducting polymer blends, composites, and colloids). Also discussed are the information about the fundamental aspects of the conducting process including charge carriers, doping processes, optical properties, and electrical conduction properties and, finally, the practical information regarding stability and applications.

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NIR photothermal therapy using polyaniline nanoparticles

Cited by 342 publications

References 43 publications

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy

Conducting Polymers

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