Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy

Abstract

In this study, we developed a nanosystem based on upconversion nanoparticles (UCNPs) coated with a layer of polyaniline nanoparticles (PANPs). The UCNP induces upconversion luminescence for imaging and photothermal conversion properties are due to PANPs. In vitro experiments showed that the UCNPs-PANPs were nontoxic to cells even at a high concentration (800 µg mL −1 ). Blood analysis and histological experiments demonstrated that the UCNPs-PANPs exhibited no apparent toxicity in mice in vivo. Besides their efficacy in photothermal cancer cell ablation, the UCNP-PANP nanosystem was found to achieve an effective in vivo tumor ablation effect after irradiation using an 808 nm laser. These results demonstrate the potential of the hybrid nanocomposites for use in imaging-guided photothermal therapy.

Photothermal Disintegration of 3T3 Derived Fat Droplets by Irradiated Silica Coated Upconversion Nanoparticles

“…Temperature rise in the colloidal solutions of the UCNPs was measured as a function of time under 980 nm illumination and its decay following the laser turned OFF (Figure S5, Supporting Information). Photothermal conversion efficiency was then calculated to be 64% and 61% for the UCNP (in hexane) and UCNP@SiO 2 (in water), respectively, which is in good agreement with previous work . In comparison, the plasmonic AuNRs and graphene oxide have PT efficiencies of around 50% and (58 ± 5)%, respectively …”

“…Our results show that the photoactive UCNPs have unmatched photostability (Figure S4b, Supporting Information), compared to common dyes, and quantum dots, and may be used for PTT in biomedical applications. We have calculated the photothermal conversion efficiencies of the UCNPs and UCNPs@SiO 2 using a standard protocol . Temperature rise in the colloidal solutions of the UCNPs was measured as a function of time under 980 nm illumination and its decay following the laser turned OFF (Figure S5, Supporting Information).…”

“…Methods—Photothermal Conversion Efficiency : Photothermal conversion efficiency measurements were performed in solutions of core and core–shell UCNPs in hexane, and water, respectively. A temperature probe, with digital readout (HT‐720 Pt, New Lab Instruments Co. Ltd., Taiwan) was inserted in the cuvette containing 1 mL of the colloidal solution, and the cuvette sealed.…”

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

“…In addition, the manufacturing of liposomal products employs rather sophisticated technologies. Various inorganic nanoscale objects are considered as components of targeted drug delivery systems; these include metal, oxide or complex oxide objects, and some other types of nanoparticles [14][15][16][17][18][19][20][21][22][23][24][25], as well as carbon clusters (fullerenes, nanotubes, graphene, and nanodiamonds) . These objects can be used, for instance, as shells or cores of nanocapsules, providing the release of drugs, for example, under local electromagnetic influence.…”

The use of nanocluster polyoxometalates in the bioactive substance delivery systems

“…In some cases, the factor contributing to the release of the transported drug from the nanocapsules may be the changing pH of the medium into which they find themselves. By their composition, the metal-containing biomedical nanoparticles are usually divided into purely metallic, e.g., gold copper, silver, and nanoparticles with a complex composition, for example, based on oxides of iron, copper, zinc, titanium, tungsten, on cerium and zirconium dioxides, including those containing rare earth metals [70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86], etc.…”