NIR Light Propulsive Janus‐like Nanohybrids for Enhanced Photothermal Tumor Therapy

Yang, Peipei; Zhai, Yuling; Qi, Guobin; Lin, Yao‐Xin; Luo, Qiang; Yang, Yang; Xu, Anping; Yang, Chao; Li, Yongsheng; Wang, Lei; Wang, Hao

doi:10.1002/smll.201601965

Cited by 68 publications

(66 citation statements)

References 39 publications

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“…Among them, gold nanoparticles have received extensive attention due to their excellent photothermal characteristics. For example, Yang et al [103] have prepared Page 12 of 19 https://doi.org/10.1007/s40820-019-0350-5 © The authors Au-BP7@SP Janus nanohybrids which show thermophoresis with active motion and enhanced PT effect (Fig. 9a).…”

Section: Cancer Cells Phototherapymentioning

confidence: 99%

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A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy

et al. 2019

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HIGHLIGHTS• Recent advances of micro/nanomotors in the field of cancer-targeted delivery, diagnosis, and imaging-guided therapy are summarized.• Challenges and outlook for the future development of micro/nanomotors toward clinical applications are discussed.ABSTRACT Micro/nanomotors have been extensively explored for efficient cancer diagnosis and therapy, as evidenced by significant breakthroughs in the design of micro/nanomotors-based intelligent and comprehensive biomedical platforms. Here, we demonstrate the recent advances of micro/nanomotors in the field of cancer-targeted delivery, diagnosis, and imaging-guided therapy, as well as the challenges and problems faced by micro/nanomotors in clinical applications. The outlook for the future development of micro/nanomotors toward clinical applications is also discussed. We hope to highlight these new advances in micro/nanomotors in the field of cancer diagnosis and therapy, with the ultimate goal of stimulating the successful exploration of intelligent micro/nanomotors for future clinical applications.

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Section: Cancer Cells Phototherapymentioning

confidence: 99%

“…Schematic illustration of a self-propulsion Au-BP@SP Janus nanoparticle for cancer cell treatment under NIR laser irradiation. Adapted from Ref [103]. with permission, copyright Wiley Ltd., 2016. b Light-guided nanomotor systems for autonomous photothermal cancer therapy.…”

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confidence: 99%

A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy

et al. 2019

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“…These composites showed thermophoretic motion, but also photothermal effects after NIR irradiation. The Janus nanohybrids had higher cell killer efficacy than Au@SP at the same concentration, probably because the active motion enhances the temperature of the treated cells even further, leading to better results [142]. Xuan et al used the traditional Janus geometry made of mesoporous silica in combination with a Au shell, while the inert half is covered with macrophage cell membranes to increase speed and circulation time, overcome biofouling and enhance target recognition of on cancer cells.…”

Section: Propulsion Strategiesmentioning

confidence: 99%

Nano-and Micromotors Designed for Cancer Therapy

2019

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Research on nano- and micromotors has evolved into a frequently cited research area with innovative technology envisioned for one of current humanities’ most deadly problems: cancer. The development of cancer targeting drug delivery strategies involving nano-and micromotors has been a vibrant field of study over the past few years. This review aims at categorizing recent significant results, classifying them according to the employed propulsion mechanisms starting from chemically driven micromotors, to field driven and biohybrid approaches. In concluding remarks of section 2, we give an insight into shape changing micromotors that are envisioned to have a significant contribution. Finally, we critically discuss which important aspects still have to be addressed and which challenges still lie ahead of us.

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“…Janus NMs are synthesized through an approach based on microfluidics, and therefore loading of the particles with proteins can be realized during synthesis [ 283 ]. Janus NMs can furthermore be filled with nanoparticles e.g., gold nanoaggregates that plays a role in enhancing photothermic tumor therapy [ 284 ]. Transport of NMs can be achieved using chemotaxis as previously considered, pH-taxis or external magnetic guidance [ 285 ].…”

Section: Towards Biomedical and Fluidic Micromachinesmentioning

confidence: 99%

Geometry Design, Principles and Assembly of Micromotors

et al. 2018

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Discovery of bio-inspired, self-propelled and externally-powered nano-/micro-motors, rotors and engines (micromachines) is considered a potentially revolutionary paradigm in nanoscience. Nature knows how to combine different elements together in a fluidic state for intelligent design of nano-/micro-machines, which operate by pumping, stirring, and diffusion of their internal components. Taking inspirations from nature, scientists endeavor to develop the best materials, geometries, and conditions for self-propelled motion, and to better understand their mechanisms of motion and interactions. Today, microfluidic technology offers considerable advantages for the next generation of biomimetic particles, droplets and capsules. This review summarizes recent achievements in the field of nano-/micromotors, and methods of their external control and collective behaviors, which may stimulate new ideas for a broad range of applications.

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NIR Light Propulsive Janus‐like Nanohybrids for Enhanced Photothermal Tumor Therapy

Cited by 68 publications

References 39 publications

A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy

A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy

Nano-and Micromotors Designed for Cancer Therapy

Geometry Design, Principles and Assembly of Micromotors

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