A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy

Wang, Jiajia; Dong, Renfeng; Wu, Huasheng; Cai, Yue‐Peng; Ren, Biye

doi:10.1007/s40820-019-0350-5

Cited by 109 publications

(73 citation statements)

References 107 publications

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“…Moreover, there are severe risks of systemic toxicity associated with uncontrollable proliferation of cell-based strategies inside the body. By contrast, synthetic microrobots have the possibility to integrate any kind of material-organic or inorganicfor improved actuation, cargo-release, imaging and sensing tasks 3,170,[195][196][197][198] and enhanced controllability. However, potential toxicity effects need to be considered, e.g.…”

Section: Discussionmentioning

confidence: 99%

Engineering microrobots for targeted cancer therapies from a medical perspective

et al. 2020

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Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approaches have been developed to overcome these issues. However, targeted delivery of therapeutics remains challenging. Engineering microrobots is increasingly receiving attention in this regard. Their functionalities, particularly their motility, allow microrobots to penetrate tissues and reach cancers more efficiently. Here, we highlight how different microrobots, ranging from tailor-made motile bacteria and tiny bubble-propelled microengines to hybrid spermbots, can be engineered to integrate sophisticated features optimised for precision-targeting of a wide range of cancers. Towards this, we highlight the importance of integrating clinicians, the public and cancer patients early on in the development of these novel technologies.

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Section: Discussionmentioning

confidence: 99%

Engineering microrobots for targeted cancer therapies from a medical perspective

et al. 2020

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“…Chemical gradients more than others have been largely exploited for the autonomous propulsion of motors at the nanoscale [184] and chemically controlled nanoparticles have shown incredible performances when applied for biomedical purposes [185,186]. This is mainly achieved through the combination of nanoparticles with biodegradable and biocompatible polymers [187] that can complete their task and in some cases disassemble into safe products [188].…”

Section: Self-propelling Active Npsmentioning

confidence: 99%

Green Plasmonic Nanoparticles and Bio-Inspired Stimuli-Responsive Vesicles in Cancer Therapy Application

et al. 2020

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In the last years, there is a growing interest in the application of nanoscaled materials in cancer therapy because of their unique physico-chemical properties. However, the dark side of their usability is limited by their possible toxic behaviour and accumulation in living organisms. Starting from this assumption, the search for a green alternative to produce nanoparticles (NPs) or the discovery of green molecules, is a challenge in order to obtain safe materials. In particular, gold (Au NPs) and silver (Ag NPs) NPs are particularly suitable because of their unique physico-chemical properties, in particular plasmonic behaviour that makes them useful as active anticancer agents. These NPs can be obtained by green approaches, alternative to conventional chemical methods, owing to the use of phytochemicals, carbohydrates, and other biomolecules present in plants, fungi, and bacteria, reducing toxic effects. In addition, we analysed the use of green and stimuli-responsive polymeric bio-inspired nanovesicles, mainly used in drug delivery applications that have revolutionised the way of drugs supply. Finally, we reported the last examples on the use of metallic and Au NPs as self-propelling systems as new concept of nanorobot, which are able to respond and move towards specific physical or chemical stimuli in biological entities.

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“…Apart from bioimaging, MNMs assisted biosensing was also well discussed and accepted in disease diagnosis (Jurado-Sánchez and Escarpa 2017; Kong et al 2018). Some efforts have been made to fulfill the need of early-stage tumor detection with the MNMs (Gao et al 2018;Wang et al 2019a). Ju and co-workers recently developed a jellyfish-like micromotor with DNA detecting assembly and biocompatible enzyme catalase, which was decorated on the concave surface of the motor (Fig.…”

Section: Imaging and Biosensingmentioning

confidence: 99%

Biofriendly micro/nanomotors operating on biocatalysis: from natural to biological environments

et al. 2020

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Micro/nanomotors (MNMs) are tiny motorized objects that can autonomously navigate in complex fluidic environments under the influence of an appropriate source of energy. Internal energy-driven MNMs are composed of certain reactive materials that are capable of converting chemical energy from the surroundings into kinetic energy. Recent advances in smart nanomaterials design and processing have endowed the internal energy-driven MNMs with different geometrical designs and various mechanisms of locomotion, with remarkable traveling speed in diverse environments ranging from environmental water to complex body fluids. Among the different design principals, MNM systems that operate from biocatalysis possess biofriendly components, efficient energy conversion, and mild working condition, exhibiting a potential of stepping out of the proof-of-concept phase for addressing many real-life environmental and biotechnological challenges. The biofriendliness of MNMs should not only be considered for in vivo drug delivery but also for environmental remediation and chemical sensing that only environmentally friendly intermediates and degraded products are generated. This review aims to provide an overview of the recent advances in biofriendly MNM design using biocatalysis as the predominant driving force, towards practical applications in biotechnology and environmental technology.

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A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy

Cited by 109 publications

References 107 publications

Engineering microrobots for targeted cancer therapies from a medical perspective

Engineering microrobots for targeted cancer therapies from a medical perspective

Green Plasmonic Nanoparticles and Bio-Inspired Stimuli-Responsive Vesicles in Cancer Therapy Application

Biofriendly micro/nanomotors operating on biocatalysis: from natural to biological environments

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