NIR-light-controlled G-quadruplex hydrogel for synergistically enhancing photodynamic therapy via sustained delivery of metformin and catalase-like activity in breast cancer

Sun, Yuhua; Fang, Kang; Hu, Xiaochun; Yang, Jingxian; Jiang, Zhengyang; Feng, Lei; Li, Ruihao; Rao, Yiming; Shi, Shuo; Dong, Chunyan

doi:10.1016/j.mtbio.2022.100375

Cited by 22 publications

(19 citation statements)

References 56 publications

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“…Recently, smart hydrogels with stimulus-responsive functions have attracted considerable attention. Briefly, stimulus-responsive hydrogels can respond to internal physiological signals (i.e., temperature [ 28 , 29 ], pH [ 30 , 31 ], redox [ 32 , 33 ], glucose [ 34 , 35 ], or enzymes [ 36 , 37 ]), external stimuli (i.e., temperature [ 38 , 39 ], magnetic field [ 40 , 41 ], pressure [ 42 , 43 ], reactive oxygen species (ROS) [ 44 , 45 ], light [ 46 , 47 ] and electric field [ 48 , 49 ]) or a combination of the above, which can reversibly or irreversibly change the physical properties or chemical structure ( Fig. 2 ).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in responsive hydrogels for diabetic wound healing

Zhang

Qin

et al. 2023

Materials Today Bio

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Section: Introductionmentioning

confidence: 99%

Recent advances in responsive hydrogels for diabetic wound healing

Zhang

Qin

et al. 2023

Materials Today Bio

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“…Zhang et al demonstrated both the bioimaging capabilities of IR775-loaded PLGA using BALB/c mice with CT26 tumors and showed that the therapeutic modalities of particles led to the tumor growth inhibition of 87.28% [ 50 ]. The heptamethine cyanine derivative, IR775 dye (2-[2-[2-chloro-3-[2-(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-ethylidene]-1-cyclohexen-1-yl]-ethenyl]-1,3,3-trimethyl-3H-indolium chloride), was shown to be one of the most effective PDT sensitizers, especially within the composition of different nanoparticles due to its hydrophobic nature [ 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…The anti-cancer efficacy is mediated by the loading of the photosensitizer, IR775 dye, into PLGA nanoparticle structure. The heptamethine cyanine derivative IR775 is one of the most effective photosensitizers, especially inside polymer nanoparticles, due to its hydrophobic nature; under external light irradiation in the near-infrared window in biological tissue, it produces reactive oxygen species (ROS) leading to cancer cell death, thus affecting only the specific tissue site only on demand under light exposure [ 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo

et al. 2022

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The extreme aggressiveness and lethality of many cancer types appeal to the problem of the development of new-generation treatment strategies based on smart materials with a mechanism of action that differs from standard treatment approaches. The targeted delivery of nanoparticles to specific cancer cell receptors is believed to be such a strategy; however, there are no targeted nano-drugs that have successfully completed clinical trials to date. To meet the challenge, we designed an alternative way to eliminate tumors in vivo. Here, we show for the first time that the targeting of lectin-equipped polymer nanoparticles to the glycosylation profile of cancer cells, followed by photodynamic therapy (PDT), is a promising strategy for the treatment of aggressive tumors. We synthesized polymer nanoparticles loaded with magnetite and a PDT agent, IR775 dye (mPLGA/IR775). The magnetite incorporation into the PLGA particle structure allows for the quantitative tracking of their accumulation in different organs and the performing of magnetic-assisted delivery, while IR775 makes fluorescent in vivo bioimaging as well as light-induced PDT possible, thus realizing the theranostics concept. To equip PLGA nanoparticles with targeting modality, the particles were conjugated with lectins of different origins, and the flow cytometry screening revealed that the most effective candidate for breast cancer cell labeling is ConA, a lectin from Canavalia ensiformis. In vivo experiments showed that after i.v. administration, mPLGA/IR775–ConA nanoparticles efficiently accumulated in the allograft tumors under the external magnetic field; produced a bright fluorescent signal for in vivo bioimaging; and led to 100% tumor growth inhibition after the single session of PDT, even for large solid tumors of more than 200 mm3 in BALB/c mice. The obtained results indicate that the mPLGA/IR775 nanostructure has great potential to become a highly effective oncotheranostic agent.

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“…In Vitro ROS Detection: In vitro ROS detection was monitored using DCFH as the indicator. [34] 5 μL DCFH (4 × 10 −3 m) and 5 μL DPCIT (4 mg mL −1 ) were added into 980 μL PBS buffer (pH 7.4) in a quartz cuvette, and a laser irradiation (808 nm, 1.5 W cm −2 ) was used to irradiate the above solution for 300 s, and the fluorescence spectrum of mixture were collected at 30 s intervals.…”

Section: Methodsmentioning

confidence: 99%

A Phase‐Change Mediated Intelligent Nanoplatform for Chemo/Photothermal/Photodynamic Therapy of Cancer

et al. 2022

Adv Healthcare Materials

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Up to now, chemotherapy is still the main strategy for cancer treatment. However, the emergence of chemo‐resistance and systemic side effects often seriously affects the treatment and prognosis. Herein, an intelligent nanoplatform based on dendritic mesoporous organosilica nanoparticles (DMON) is constructed. The encapsulated phase‐change material, 1‐tetradecanol (TD) can serve as a “doorkeeper” and enable the responsive release of drugs based on the temperature changes. Meanwhile, polyethylene glycol (PEG) is used to improve the dispersibility and biocompatibility. Cisplatin is chosen as the model of chemotherapy drug, which is co‐loaded with indocyanine green (ICG) in DMON to produce DMON‐PEG‐cisplatin/ICG‐TD (DPCIT). Exciting, the hyperthermia and reactive oxygen species induced by ICG under the NIR‐laser irradiation will initiate a phase transition of TD to release cisplatin, thus leading a combined therapy (chemo/photothermal/photodynamic therapy). The results indicated that under laser irradiation, DPCIT can kill cancer cells and inhibit tumor growth efficiently. In addition, the designed nanoplatform reveals minimal systemic toxicity in vivo, in contrast, the distinct liver damage can be observed by the direct treatment of cisplatin. Overall, this research may provide a general approach for the targeted delivery and controlled release of chemotherapy drugs to realize a cooperatively enhanced multimodal tumor therapy.

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NIR-light-controlled G-quadruplex hydrogel for synergistically enhancing photodynamic therapy via sustained delivery of metformin and catalase-like activity in breast cancer

Cited by 22 publications

References 56 publications

Recent advances in responsive hydrogels for diabetic wound healing

Recent advances in responsive hydrogels for diabetic wound healing

Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo

A Phase‐Change Mediated Intelligent Nanoplatform for Chemo/Photothermal/Photodynamic Therapy of Cancer

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