A Phase‐Change Mediated Intelligent Nanoplatform for Chemo/Photothermal/Photodynamic Therapy of Cancer

Abstract

Up to now, chemotherapy is still the main strategy for cancer treatment. However, the emergence of chemo‐resistance and systemic side effects often seriously affects the treatment and prognosis. Herein, an intelligent nanoplatform based on dendritic mesoporous organosilica nanoparticles (DMON) is constructed. The encapsulated phase‐change material, 1‐tetradecanol (TD) can serve as a “doorkeeper” and enable the responsive release of drugs based on the temperature changes. Meanwhile, polyethylene glycol (PEG) is used to improve the dispersibility and biocompatibility. Cisplatin is chosen as the model of chemotherapy drug, which is co‐loaded with indocyanine green (ICG) in DMON to produce DMON‐PEG‐cisplatin/ICG‐TD (DPCIT). Exciting, the hyperthermia and reactive oxygen species induced by ICG under the NIR‐laser irradiation will initiate a phase transition of TD to release cisplatin, thus leading a combined therapy (chemo/photothermal/photodynamic therapy). The results indicated that under laser irradiation, DPCIT can kill cancer cells and inhibit tumor growth efficiently. In addition, the designed nanoplatform reveals minimal systemic toxicity in vivo, in contrast, the distinct liver damage can be observed by the direct treatment of cisplatin. Overall, this research may provide a general approach for the targeted delivery and controlled release of chemotherapy drugs to realize a cooperatively enhanced multimodal tumor therapy.

Embedding Atomically Dispersed Manganese/Gadolinium Dual Sites in Oxygen Vacancy‐Enriched Biodegradable Bimetallic Silicate Nanoplatform for Potentiating Catalytic Therapy

“…Then, photogenerated electrons in the CB of PMn SA GMSNs-V can capture O 2 to further produce • O 2 − . While photogenerated holes in the VB of PMn SA GMSNs-V cannot directly convert H 2 O into • OH, but holes can combine with • O 2 − and convert it into 1 O 2 (11). [2b] Benefiting from atomic dispersed Mn sites in PMn SA GMSNs-V, PMn SA GMSNs-V can generate • OH and • O 2 − by POD-like and OXD-like activities, respectively.…”

“…[10] PDT, which relies on external energy to convert O 2 into ROS, is one of the most optimum anticancer therapies because of its minimal side effects, good therapeutic effect, and strong spacetime specificity. [11] Due to its high singlet quantum yield, strong tissue penetration, high biocompatibility, and good PDT efficiency, Chlorin e6 (Ce6) has been widely employed for PDT. [12] However, low ROS generation induced by hypoxia TME and quick energy attenuation often leads to limited PDT effects.…”

A Novel Polymer Enabled by Polymerized Small Molecule Strategy for Tumor Photothermal and Photodynamic Therapy

“…Next, the ROS generation from PYT NPs was further evaluated under the uorescent inverted microscope. 2,7-dichlorodi-hydro uorescein diacetate (DCFH-DA) is used to detect intracellular ROS level [22][23][24]. As shown in Fig.…”

A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy

“…Next, the ROS generation from PYT NPs was further evaluated under the fluorescent inverted microscope. 2,7-dichlorodi-hydrofluorescein diacetate (DCFH-DA) was used to detect intracellular ROS level [39][40][41]. As shown in Fig.…”