Nimesulide induced Stevens Johnson syndrome (SJS); managed successfully with combined approach of steroids, intravenous immunoglobulin and placentrex gel: A case report

Raj, Rakesh Tilak; Kaur, Baljinder; Lochan, Krishan Kumar; Bahl, Rakesh Kumar

doi:10.7241/ourd.20144.68

Cited by 3 publications

(2 citation statements)

References 18 publications

(16 reference statements)

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“…The placental extract possesses anti-inflammatory, antioxidative, and antiplatelet effects. It also enhances the impact of cell-mediated and humoral-mediated immunity (Cianfarani et al, 2006, Raj et al, 2014, Shing et al, 2017. In this context, the present research was designed to evaluate the effectiveness of placental extract gel in the treatment of minor recurrent aphthous ulcers.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Placental Extract Gel in the Treatment of Recurrent Aphthous Stomatitis: Randomized Clinical

Morsy

2022

Egyptian Dental Journal

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Background:The most frequent oral ulcer that affects non keratinized oral mucosa is recurrent Aphthous stomatitis (RAS). The goal of the current investigation was to determine the effectiveness of the topical application of placental extract gel (PEG) in the treatment of RAS.Materials and methods: 40 patients with RAS participated in this research. They were randomly allocated into two groups. Group I (control): include 20 patients treated with topical application of benzydamine hydrochloride gel and group II (test group) include 20 patients treated with topical application of placental extract gel. The effectiveness of the treatment modalities was assessed by measuring pain intensity, ulcer size at baseline, 3 rd day and 7 th day.Results: both treated groups showed a statistically significant decrease (P≤ 0.001) in pain intensity and ulcer size at days 3 and 7 compared to baseline data. However, the RAS treated with PEG showed statistical significant decrease (P≤ 0.001) in pain intensity and ulcer size at days 3 and 7 compared to the control group. Conclusion:Topical PEG is an effective topical agent in RAS treatment, which enhances the patient's normal activities and daily life events.

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Section: Discussionmentioning

confidence: 99%

The Effectiveness of Placental Extract Gel in the Treatment of Recurrent Aphthous Stomatitis: Randomized Clinical

Morsy

2022

Egyptian Dental Journal

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“…3 In India, Nimesulide is easily available as an over the counter drug (OTC), different cutaneous reactions associated with, Nimesulide including Angioedema, maculo-popular rash, severe urticaria, pityriasis rosea and worsening of preexisting psoriasis. 4 Indian government restricted its use in 2011 for paediatric purposes in the age group of less than 12 years 4 . Hereby presenting a case of SJS/TEN overlap due to Nimesulide.…”

Section: Introductionmentioning

confidence: 99%

A case report of Steven Johnson’s Syndrome (SJS) /Toxic Epidermal Necrolysis(TEN) overlap caused by Nimesulide

Chirag U Nayee,

Amita R Kubavat

2024

World J. Bio. Pharm. Health Sci.

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Introduction: Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare, acute and life-threatening mucocutaneous diseases that are nearly always drug-related. Incidence of SJS and TEN is 0.05 to 2 persons per million populations per year. In India, Nimesulide is easily available as an over the counter drug (OTC), different cutaneous reactions associated with, Nimesulide including angioedema, maculo-papular rash, severe urticaria, pityriasis rosea and worsening of preexisting psoriasis. Patient concern (Case summary): A 17 years old female patient complained about fever and she was prescribed with Tab.Nimesulide twice daily by private practitioner. On the 3rd day of intake of oral Nimesulide, patient developed skin lesions over face, trunk, back and all four limbs. This reaction was diagnosed as Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) overlap by Nimesulide based on clinical picture and drug history. Interventions: Tab. Nimesulide was stopped and patient was admitted in dermatology ward. Patient was treated with Inj.Hydrocortisone sodium succinate 100mg iv twice daily, Inj.Cefotaxime 1gm iv thrice a daily, Inj. Metronidazole 500mg once a day and Liquid Cyclosporine 50mg twice a day for 10days. Other treatments included Inj. Albumin 100ml i.v slowly for 3 days given. Patient recovered and was discharged after 10 days. Conclusion: We are presenting a case of SJS-TEN overlap caused by Nimesulide, which is commonly used as an over the counter drug (OTC). Our aims to minimize this type of serious ADR by making alert to physicians and other healthcare professionals, we can avoid hospital admissions because of ADR, reduce economic burden of the patients and health related quality of life of the patient can be improved.

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Does Topical Application of Placental Extract Gel on Postoperative Fibrotomy Wound Improve Mouth Opening and Wound Healing in Patients With Oral Submucous Fibrosis?

Thakur

Thomas

Bhargava

et al. 2015

Journal of Oral and Maxillofacial Surgery

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Nimesulide induced Stevens Johnson syndrome (SJS); managed successfully with combined approach of steroids, intravenous immunoglobulin and placentrex gel: A case report

Cited by 3 publications

References 18 publications

The Effectiveness of Placental Extract Gel in the Treatment of Recurrent Aphthous Stomatitis: Randomized Clinical

The Effectiveness of Placental Extract Gel in the Treatment of Recurrent Aphthous Stomatitis: Randomized Clinical

A case report of Steven Johnson’s Syndrome (SJS) /Toxic Epidermal Necrolysis(TEN) overlap caused by Nimesulide

Does Topical Application of Placental Extract Gel on Postoperative Fibrotomy Wound Improve Mouth Opening and Wound Healing in Patients With Oral Submucous Fibrosis?

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