Does Topical Application of Placental Extract Gel on Postoperative Fibrotomy Wound Improve Mouth Opening and Wound Healing in Patients With Oral Submucous Fibrosis?

Thakur, Gagan; Thomas, Shaji; Bhargava, Darpan; Pandey, Ankit

doi:10.1016/j.joms.2015.03.020

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…Daily wound debridement was done, supplemented by the application of placentrex gel which aids in faster granulation. In our experience placentrex gel has a very good effect on the healing of oral wounds and should be used more frequently [13]. …”

Section: Discussionmentioning

confidence: 99%

Our Experience in the Management of Traumatic Wound Myiasis: Report of 3 Cases and Review of the Literature

Shukla

Kamath

Kudva

et al. 2016

Case Reports in Dentistry

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Section: Discussionmentioning

confidence: 99%

Our Experience in the Management of Traumatic Wound Myiasis: Report of 3 Cases and Review of the Literature

Shukla

Kamath

Kudva

et al. 2016

Case Reports in Dentistry

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“…Thakur et al performed a fibrotomy followed by applying placental extract gel topically over the wound in 10 patients where the mouth opening was less than 20 mm and a buccal pad of fat was used for reconstruction. They found that the median postoperative improvement in mouth opening after four weeks was 15 mm [ 4 ]. The mouth opening in the above-mentioned series was much better than the outcome in our study.…”

Section: Discussionmentioning

confidence: 99%

“…The study was approved by the institutional ethics committee The sample size was estimated based on the mean difference in mouth opening pre-operatively and postoperatively as reported in the study by Thakur et al [4]. The study reported an average variance estimate of 2.7 in the mouth opening score with 80% power and an alpha error of 5%.…”

Section: Methodsmentioning

confidence: 99%

“…Various methods of treatment have been tried in these cases, like steroids, hyaluronic acid, lycopene, curcumin, turmeric, aloe vera, pentoxifylline, iron supplements, fibrinolytic agents, fibrotomy, and removal of fibrous bands using light amplification by stimulated emission of radiation (LASER), with varying degrees of success [ 3 , 4 ]. In the early stages of OSMF, conservative management like cessation of habits and medical management like antioxidants, nutritional, iron, and vitamin supplements, along with corticosteroids, are considered [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparison Between Clinical Outcome of Intralesional Human Placental Extract Alone and Topical Application of Placental Extract Gel After Fibrotomy in Oral Submucous Fibrosis

Zuali,

Mohiyuddin,

et al. 2023

Cureus

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Background: Oral submucous fibrosis (OSMF) is a premalignant condition prevalent in our country. Juxtaepithelial inflammation with progressive hyalinization of the lamina propria results in stiffness and fibrosis of the oral mucosa, characterised by trismus, ankyloglossia, and a burning sensation. Various methods of treatment have been tried in these cases, which include placental extract injections and the cutting of fibrous bands. In this study, we aim to compare the outcome of intra-lesional placental extract injection with fibrotomy and placental extract gel application in OSMF.Methodology: This prospective interventional study included 58 patients clinically diagnosed with OSMF grades II and III at a rural tertiary care hospital between January 2021 and August 2022. The patients were randomised into two groups: group I received 1 ml of intra-lesional human placental extract injection in the submucosal plane of the buccal mucosa and retro-molar trigone (RMT) once a week for five consecutive weeks, and group II was subjected to a transverse division of fibrotic bands in the submucosal plane under general anaesthesia. The surgical wound was left open, and swabs soaked in human-purified placental extract gel were placed in the wound for two hours twice daily until the surgical wound was epithelialized and healed. The patients in both groups I and II were advised to do jaw opening exercises, and weekly followup was done. Findings with regard to maximum mouth opening, colour of mucosa, and burning sensation in the oral cavity based on a Likert scale were documented. At the end of five months, the pre-treatment and post-treatment results documented were compared.Results: All patients were between 20 and 60 years of age and were addicted to chewing areca nuts with tobacco. Bilateral involvement was present in all patients, with extension into the RMT and soft palate seen in 31%. Improvement in mouth opening was between 4 mm and 6 mm in group II, and relief of burning sensation and mucosal colour was better in group I.Conclusion: Intra-lesional placental extract injections help in the improvement of the mucosa and relief from the burning sensation. Fibrotomy with placental extract gel application is better at relieving trismus in OSMF. Aggressive mouth-opening exercises may improve mouth opening following the above procedures.

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“…ГПЧ применяются для лечения подслизистого фиброза полости рта -хронического, прогрессирующего заболевания, ассоциированного с болевым синдромом, ограничениями при открытии рта и повышенным риском злокачественных новообразований [64]. Топическое применение ГПЧ улучшало раскрытие рта и заживление ран у пациентов с подслизистым фиброзом, прошедшими фибротомию с короноидэктомией [65]. В частности, разработан способ лечения хронического процесса при воспалительных заболеваниях слизистой оболочки рта с элементами гиперкератоза.…”

Section: заживление ран поддержание состояния кожи и её придатковunclassified

Worldwide experience of the therapeutic use of the human placental hydrolytes

Торшин

Громова

2020

jour

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Here we present the results of a systematic analysis of publications on the clinical and the experimental pharmacology of human placental hydrolyzates (HPH). Searches were performed in the PUBMED, ELIBRARY and RSL databases. The results of the analyses of the peptide composition of HPH allowed us to formulate a number of previously unknown molecular mechanisms of their action. In the article we examine the effects of HPH in the therapy of liver diseases, atopic dermatitis, herpetic infection, viral hepatitis, joint diseases, iron overload, chronic fatigue syndrome and consider the general regenerative abilities of the HPH.

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Does Topical Application of Placental Extract Gel on Postoperative Fibrotomy Wound Improve Mouth Opening and Wound Healing in Patients With Oral Submucous Fibrosis?

Cited by 8 publications

References 8 publications

Our Experience in the Management of Traumatic Wound Myiasis: Report of 3 Cases and Review of the Literature

Our Experience in the Management of Traumatic Wound Myiasis: Report of 3 Cases and Review of the Literature

Comparison Between Clinical Outcome of Intralesional Human Placental Extract Alone and Topical Application of Placental Extract Gel After Fibrotomy in Oral Submucous Fibrosis

Worldwide experience of the therapeutic use of the human placental hydrolytes

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