Nikolaj Nikolajewitsch Anitschkow (1885–1964) established the cholesterol-fed rabbit as a model for atherosclerosis research

Finking, Gerald; Hanke, Hartmut

doi:10.1016/s0021-9150(97)00161-5

Cited by 134 publications

(107 citation statements)

References 62 publications

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“…The atheromatose lesions in this animal are similar to those in humans also in sequence, as confirmed en aortic atherosclerosis [116], making this animal a universal model for studying the anti-atherogenic activity of many drugs [117][118][119][120]. For the characteristics detailed below, the New Zealand rabbit is an excellent model to reproduce human atheromatosis because: i) it is possible to induce hypercholesterolaemia in a few days after administration of a highcholesterol diet [121]; ii) it is sensitive to the induction of atheromatose lesions [116]; iii) hypercholesterolaemia results from excess LDL [122]; iv) excess cholesterol is eliminated from the tissues to be incorporated in high-density lipoproteins (HDL) [4]; vi) it is capable of forming cholesterol-HDL complexes associated with apoE which are transported by the blood to the liver [4]; vii) the lipoprotein profile is similar in size to that of humans in the highest range, with HDl being practically the same [123]; viii) it presents postprandial hyperlipaemia for the existence of chilomicron remnants [124]; ix) the hyperlipaemic diet increases apoE [125]; and x) the sustained alteration of lipids after feeding with a cholesterolrich diet is reversible when the diet is replaced by a normal one [121].…”

Section: Rabbitsmentioning

confidence: 73%

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

Sebastián¹,

Corral²,

Montañana³

et al. 2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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Section: Rabbitsmentioning

confidence: 73%

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

Sebastián¹,

Corral²,

Montañana³

et al. 2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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“…In 1908, Ignatowski showed that meat -containing the pro-oxidant iron -fed to adult rabbits, or milk and egg yolks fed to weanling rabbits, induced atherosclerosis (48). In 1913, Anitschkov established the cholesterol-fed rabbit as a model for dietary atherosclerosis (49). Cholesterol feeding in rabbits not only causes cholesterol accumulation in plasma and the arterial wall but also promotes inflammation and cell proliferation, which may be blocked by the anti-inflammatory agent cortisone to prevent the formation of raised atherosclerotic lesions (50).…”

Section: Adverse Effects Of Dietary Cholesterolmentioning

confidence: 99%

Dietary cholesterol and egg yolks: Not for patients at risk of vascular disease

Spence¹,

Jenkins

Davignon³

2010

Canadian Journal of Cardiology

121

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“…The cholesterol-fed rabbit has been used as an animal model of atherosclerosis since 1913 when Anitchkow first demonstrated that a cholesterol diet induced vascular lesions (Bocan, 1998;Fan & Watanabe, 2000;Finking & Hanke, 1997;Moghadasian, 2002). More recently, the cholesterol-fed rabbit has been proposed as an animal model of Alzheimer's disease (Ghribi, Larsen, Schrag, & Herman, 2006;Sjogren, Mielke, Gustafson, Zandi, & Skoog, 2006 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication.…”

Section: Cholesterol Enhances Rabbit Heart Rate Conditioningmentioning

confidence: 99%

Cholesterol enhances classical conditioning of the rabbit heart rate response

Schreurs

Smith-Bell

Darwish

et al. 2007

Behavioural Brain Research

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The cholesterol-fed rabbit is a model of atherosclerosis and has been proposed as an animal model of Alzheimer's disease. Feeding rabbits cholesterol has been shown to increase the number of beta amyloid immunoreactive neurons in the cortex. Addition of copper to the drinking water of cholesterol-fed rabbits can increase this number still further and may lead to plaque-like structures. Classical conditioning of the nictitating membrane response in cholesterol-fed rabbits is retarded in the presence of these plaque-like structures but may be facilitated in their absence. In a factorial design, rabbits fed 2% cholesterol or a normal diet (0% cholesterol) for 8 weeks with or without copper added to the drinking water were given trace classical conditioning using a tone and periorbital electrodermal stimulation to study the effects of cholesterol and copper on classical conditioning of heart rate and the nictitating membrane response. Cholesterol-fed rabbits showed significant facilitation of heart rate conditioning and conditioning-specific modification of heart rate relative to normal diet controls. Consistent with previous research, cholesterol had minimal effects on classical conditioning of the nictitating membrane response when periorbital electrodermal stimulation was used as the unconditioned stimulus. Immunohistochemical analysis showed a significant increase in the number of beta amyloid positive neurons in the cortex, hippocampus and amygdala of the cholesterol-fed rabbits. Supplementation of drinking water with copper increased the number of beta amyloid positive neurons in the cortex of cholesterol-fed rabbits but did not produce plaque-like structures or have a significant effect on heart rate conditioning. The data provide additional support for our finding that, in the absence of plaques, dietary cholesterol may facilitate learning and memory. Cholesterol enhances rabbit heart rate conditioningThe cholesterol-fed rabbit has been used as an animal model of atherosclerosis since 1913 when Anitchkow first demonstrated that a cholesterol diet induced vascular lesions (Bocan, 1998;Fan & Watanabe, 2000;Finking & Hanke, 1997;Moghadasian, 2002). More recently, the cholesterol-fed rabbit has been proposed as an animal model of Alzheimer's disease (Ghribi, Larsen, Schrag, & Herman, 2006;Sjogren, Mielke, Gustafson, Zandi, & Skoog, 2006 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Sparks, 1997;Sparks, Martin, Gross, & Hunsaker III, 2000;Zatta, Zambenedetti, Stella, & Licastro, 2002). Based on the observation that patients with heart disease had beta amyloid st...

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Nikolaj Nikolajewitsch Anitschkow (1885–1964) established the cholesterol-fed rabbit as a model for atherosclerosis research

Cited by 134 publications

References 62 publications

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

Dietary cholesterol and egg yolks: Not for patients at risk of vascular disease

Cholesterol enhances classical conditioning of the rabbit heart rate response

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