Nigella Sativa Oil as a Pulp Medicament for Pulpotomized Teeth: A Histopathological Evaluation

Abstract

Purpose: Concerns about the safety of formocresol (FC) as a pulpotomy agent in Pediatric Dentistry have lead to the search of new capping medicaments. Indigenous plant medicines such as Nigella Sativa (NS) have been the focus of many researches. Therefore the purpose of this study was to investigate histo-pathologically the pulp response to NS oil and FC in dogs. Method: Forty teeth in 4 male dogs of undefined breed aging 12-14 months were used in this study. Coronal access cavities were performed on the upper and lower premolars so that both medicaments were tested in the same animal in alternate sides of the mouth. Four weeks after treatment the animals were sacrificed, paraffin sections were prepared for histological, histochemical and immuno-histochemical staining. Results: specimens in the NS group showed mild to moderate vasodilatation. Few specimens showed scattered inflammatory cell infiltration and the odontoblastic layer was continuous. While the FC group showed moderate to severe vasodilatation with high inflammatory cell infiltrate and degenerative changes. Conclusions: NS possesses an anti-inflammatory effect and the pulp maintains its vitality after its application, which could qualify its use as a pulp medicament for pulpotomized teeth in clinical practice.

Comparative Evaluation of Pulpal Response to Tri-antibiotic Paste and Allium Sativum with Formacresol as Pulpotomy Medication in Primary Teeth:An in vivo Study

“…The results of current study revealed that there was moderate to sever inflammation in formacresol treated group and presence of sever pulpal fibrosis.These findings are in agreement with Omar et al, (25) . Moreover, there was internal root resorption in formacresol group and there were partial and complete necrosis in 66.6% of cases because it increases the inflammation of pulp tissues and formations of abscess (26) .…”

Evaluation of Medicinal Plant Extract Versus Traditional Medicament Used for Vital Pulpotomy of Primary Molars

“…Abscess formation was also observed in the pulp space, this is because formocresol leaves the pulp chronically inflamed which increase the susceptibility of abscess formation (17) . This finding is similar to an earlier study which reported abscess formation in pulp treated with formocresol (18) .…”

In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention

“…Thymoquinone (TQ) is the major ingredient in N. sativa seed essential oil, which has been proved to have broad medical benefits [ 43 , 44 , 45 ]. In addition, N. sativa seed extract has been tested recently in the dental field for a potential therapeutic effect against dental caries [ 46 ], pulpal diseases [ 47 ], gingival and periodontal diseases [ 48 ], and oral ulcerations [ 49 ].…”