Nicotine-induced memory impairment by increasing brain oxidative stress

Hrițcu, Lucian; Ciobîcă, Alin; Gorgan, Lucian

doi:10.2478/s11535-009-0029-x

Cited by 30 publications

(28 citation statements)

References 46 publications

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“…Chronic usage of morphine diminishes mitochondrial GPx activity and various dosage regimens of morphine can block this effect ( Figure 5). Previous studies have demonstrated that reduced GPx activity can be used as a marker for oxidative stress [41]. GPx plays a prominent role in scavenging free radicals and inhibiting lipid peroxidation [42].…”

Section: Discussionmentioning

confidence: 99%

The effect of various morphine weaning regimens on the sequelae of opioid tolerance involving physical dependency, anxiety and hippocampus cell neurodegeneration in rats

Motaghinejad

Karimian

Motaghinejad

et al. 2015

Fundamemntal Clinical Pharma

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Chronic consumption of morphine induces physical dependency, anxiety, and neurodegeneration. In this study, morphine on its own has been used for the management of morphine-induced dependency, oxidative stress, and apoptosis. Forty-eight male rats were randomly divided into six groups. Rats in groups 1-5 were made morphine dependent by an increasing manner of morphine for 7 days (15-45 mg/kg). For the next 14 days, morphine was administered using the following regimen: (i) once daily 45 mg/kg (positive controls), (ii) the same dose at additional intervals (6 h longer than the previous intervals each time), (iii) 45 mg/kg of morphine at irregular intervals like of 12, 24, 36 h, (iv) decreasing dose once daily (every time 2.5 mg/kg less than the former dosage). Group 5 received 45 mg/kg of morphine and 10 mg/kg of SOD mimetic agent (M40401) injection per day. Group 6 (negative control) received saline solution only. On day 22, all animals received naloxone (3 mg/kg) and their Total Withdrawal Index (TWI) and blood cortisol levels were measured. After drug treatment, hippocampus cells were isolated, and oxidative, antioxidative, and apoptotic factors were evaluated. Various regimens of morphine reduced TWI, cortisol levels, Bax activity, caspase-3, caspase-9, TNF-α, and IL-1β and lipid peroxidation. In all treatment groups, GSH level, superoxide dismutase, glutathione peroxidase, and Bcl-2 activity were significantly increased. Furthermore, SOD mimetic agent c diminished morphine effect on SOD activity. Thus, varying the dosage regimen of morphine can reduce the severity of morphine-induced dependency and neurodegeneration.

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Section: Discussionmentioning

confidence: 99%

The effect of various morphine weaning regimens on the sequelae of opioid tolerance involving physical dependency, anxiety and hippocampus cell neurodegeneration in rats

Motaghinejad

Karimian

Motaghinejad

et al. 2015

Fundamemntal Clinical Pharma

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“…Asap rokok mampu menurunkan kadar SOD paru-paru mencit karena dalam asap rokok sebagai radikal terdapat senyawa-senyawa yang dapat merusak aktivitas enzim endogen yang berperan sebagai prooksidan. Penurunan kadar SOD akibat paparan asap rokok didukung penelitian Hritchu dkk [24] dimana dalam asap rokok yang mengandung nikotin dan diberikan pada tikus dapat menurunkan aktivitas SOD dan GPX. Penelitian Arumugam dkk [25] yang menyatakan penurunan tingkat SOD merupakan perwujudan dalam kerusakan hepatoseluler akibat adanya peningkatan produksi ROS (Reactive Oxygen Species) pada tingkat yang melebihi kemampuan akibat induksi etanol jangka panjang.…”

Section: Kadar Superoksida Dismutase (Sod) Pada Paru-paru Mencitunclassified

Pengaruh Ekstrak Etanol 90% terhadap Kadar Malondialdehid (MDA) dan Superoksida Dismutase (SOD) Mencit Tikus yang Dipapar Asap Rokok

Prayitno

Kusnadi²,

Muritni³

2018

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<pre>Cigarette smoke is a source of free radicals which cause human body organs damage when it is exposed. Cigarette smoke as a medium that causes oxidative stress that has the potential to cause oxidative damage. In addition, cigarette smoke also has potency to reduce SOD (Superoxide dismutase) levels and increase MDA (Malondialdehyde) levels especially in lung tissue. To control or prevent the presence of free radicals in the body, antioxidant compounds are needed by the body. The purpose of this research is to know the effect of the extract of red betle on SOD and MDA content of mice exposed to cigarette smoke. Red betle was extracted by maceration using ethanol. The exposed mice were treated with red betle extract for 14 days. Lung tissue of the mice was analyzed SOD and MDA conentrations. The results showed that SOD levels tend to increase and decrease MDA levels in mice test animals exposed to cigarette smoke. The optimal dose to decrease MDA levels and increase SOD is 230.4 mg/g weight/day. Histopatology result showed there is different figure of lung tissue (alveoli) before and after red betle extract treatment.</pre> Asap rokok adalah sumber radikal bebas yang dapat mengakibatkan rusaknya organ dalam tubuh manusia apabila terpapar. Asap rokok sebagai media penyebab terjadinya stress oksidatif yang berpotensi menyebabkan kerusakan oksidatif. Selain itu, asap rokok juga berpotensi dalam menurukan kadar SOD (Superoksida Dismutase) dan meningkatkan kadar MDA (Malondialdehida) terutama pada jaringan paru. Untuk mengendalikan atau mencegah adanya radikal bebas ke dalam tubuh maka senyawa antioksidan dibutuhkan oleh tubuh. Tujuan penelitian adalah adalah mengetahui pengaruh ekstrak etanol daun sirih merah terhadap kadar SOD dan MDA mencit yang dipapar asap rokok. Daun sirih merah diekstrak menggunakan metode maserasi. Mencit yang telah dipapar asap rokok diberi perlakuan ekstrak selama 14 hari. Jaringan paru-paru dianalisis kadar MDA dan SOD. Hasil penelitian menunjukan kadar SOD cenderung mengalami peningkatan dan kadar MDA mengalami penurunan pada hewan uji mencit yang dipapar asap rokok. Dosis yang paling optimal untuk menurunkan kadar MDA dan menaikan SOD adalah dosis 230,4 mg/g bb/hari. Hasil histopatologi menunjukkan terdapat perbedaan gambaran jaringan paru-paru (alveoli) sebelum dan setelah perlakuan ekstrak.

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“…Afterwards, samples were centrifuged at 3000 rpm for 10 min and supernatant absorbance read at 532 nm. The signal was read against an MDA standard curve and the results were expressed as nmol/mg protein [30,31].…”

Section: Malondialdehyde Measurementmentioning

confidence: 99%

The interactions between the cholinergic and catecholaminergic systems - focusing on memory and oxidative stress

Ciobîcă¹,

Lefter²,

Stoica³

2017

Fiziol Zh

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Nicotine-induced memory impairment by increasing brain oxidative stress

Cited by 30 publications

References 46 publications

The effect of various morphine weaning regimens on the sequelae of opioid tolerance involving physical dependency, anxiety and hippocampus cell neurodegeneration in rats

The effect of various morphine weaning regimens on the sequelae of opioid tolerance involving physical dependency, anxiety and hippocampus cell neurodegeneration in rats

Pengaruh Ekstrak Etanol 90% terhadap Kadar Malondialdehid (MDA) dan Superoksida Dismutase (SOD) Mencit Tikus yang Dipapar Asap Rokok

The interactions between the cholinergic and catecholaminergic systems - focusing on memory and oxidative stress

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