Nickel ions bind to HSP90β and enhance HIF-1α-mediated IL-8 expression

Asakawa, Shuichi; Onodera, Ryo; Kasai, Koji; Kishimoto, Y.; Sato, Taiki; Segawa, Ryosuke; Mizuno, Natsumi; Ogasawara, Kunio; Moriya, Takuya; Hiratsuka, Masahiro; Hirasawa, Noriyasu

doi:10.1016/j.tox.2018.01.006

Cited by 18 publications

(9 citation statements)

References 37 publications

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“…Nickel (II) inhibited LPS‐induced production of IL‐6, but not that of tumour necrosis factor‐α (TNF‐α) both in vivo and in vitro . In another study by the same group (Asakawa et al., 2018), it was shown that nickel ions bind to the heat‐shock protein 90‐β and enhance HIF‐1α‐mediated IL‐8 expression.…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of postimplantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL 10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 lg/kg bw. Eczematous flare-up reactions in the skin elicited in nickel-sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest-observed-adverse-effect-level of 4.3 lg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel-sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.

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Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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“…In fact, Vanadate- a vanadium oxoanion, is known to induce expression of HIF-1α in a hypoxia-like manner, which in turn leads to progression and metastasis of cancer by increasing expression of vascular endothelial growth factor (VEGF) [ 74 ]. Nickel is also known to cause sustained activation of HIF-1α in different human cells [ 75 , 76 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of arsenic and heavy metals on metabolic pathways in cells of human origin: Similarities and differences

et al. 2021

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“…Nickel is a metal that easily induces allergic responses and inflammation. It binds to proteins making novel antigens and also activates transcription factor hypoxia-induced factors [45,46] by inhibiting its degradation. Because the nickel-induced allergic response is classified mainly as a type-IV allergy and because there is no good experimental model, the roles of histamine in metal inflammation and allergy have not been thoroughly examined.…”

Section: Histamine Production In Vivo and The Functions Of Inducedmentioning

confidence: 99%

Expression of Histidine Decarboxylase and Its Roles in Inflammation

Hirasawa

2019

IJMS

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Histamine is a well-known mediator of inflammation that is released from mast cells and basophils. To date, many studies using histamine receptor antagonists have shown that histamine acts through four types of receptors: H1, H2, H3, and H4. Thus, histamine plays more roles in various diseases than had been predicted. However, our knowledge about histamine-producing cells and the molecular mechanisms underlying histamine production at inflammatory sites is still incomplete. The histamine producing enzyme, histidine decarboxylase (HDC), is commonly induced at inflammatory sites during the late and chronic phases of both allergic and non-allergic inflammation. Thus, histamine levels in tissues are maintained at effective concentrations for hours, enabling the regulation of various functions through the production of cytokines/chemokines/growth factors. Understanding the regulation of histamine production will allow the development of a new strategy of using histamine antagonists to treat inflammatory diseases.

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Nickel ions bind to HSP90β and enhance HIF-1α-mediated IL-8 expression

Cited by 18 publications

References 37 publications

Update of the risk assessment of nickel in food and drinking water

Update of the risk assessment of nickel in food and drinking water

Effects of arsenic and heavy metals on metabolic pathways in cells of human origin: Similarities and differences

Expression of Histidine Decarboxylase and Its Roles in Inflammation

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