Expression of Histidine Decarboxylase and Its Roles in Inflammation

Hirasawa, Noriyasu

doi:10.3390/ijms20020376

Cited by 58 publications

(47 citation statements)

References 85 publications

(82 reference statements)

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“…Histamine is a crucial inflammatory mediator produced by many cell types, such as mast cells, basophils, macrophages, and neurons [ 1 ]. In patients with allergic rhinitis (AR), the cross-linking of IgE on mast cells/basophils by antigens induces degranulation and histamine release, causing sneezing reactions, nasal discharge, and nasal obstruction [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling

Iwasaki¹,

Shimizu²,

Oikawa³

et al. 2021

PLoS ONE

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Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine. Moreover, recent studies have revealed that macrophages, especially alternatively activated macrophages (M2) induced by T helper 2 (Th2) cytokines, such as interleukin (IL)-4 and IL-13, participate in the pathogenesis of allergic diseases. The major source of Th2 cytokines is antigen-specific Th2 cells. To elucidate the relationship between histamine, macrophages, and Th2 cells in allergic inflammation, we established a macrophage-Th2 cell co-culture model in vitro and an antigen-specific Th2 cell transfer mouse model of rhinitis. In vitro analyses indicated that macrophages produce histamine by interacting with antigen-specific Th2 cells through the antigen. Furthermore, Th2 cells and macrophages cooperatively elicited rhinitis in the mouse model. We determined that histamine induces Th2- and macrophage-elicited sneezing responses through H1 receptor signaling, whereas it induces nasal eosinophil infiltrations through H4 receptor signaling. Collectively, these results indicate a novel histamine production mechanism by macrophages, in which Th2 cells and macrophages cooperatively induce nasal allergic inflammation through histamine signaling.

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Section: Introductionmentioning

confidence: 99%

Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling

Iwasaki¹,

Shimizu²,

Oikawa³

et al. 2021

PLoS ONE

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“…Therefore, cytokine involvement may already have occurred by the time the treatment agent was introduced, and the in ammatory response would have started shifting toward mediator synthesis and degranulation. Dexamethasone is known to strongly inhibit histamine synthesis (N Hirasawa et al, 2001;Noriyasu Hirasawa, 2019). This may explain the high rate of protection seen with dexamethasone in the therapeutic model but not the prophylactic.…”

Section: Discussionmentioning

confidence: 99%

Hydro ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation

Antwi¹,

Oduro-Mensah²,

Obiri³

et al. 2020

Preprint

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Background: Holarrhena floribunda stem bark has anecdotal use in Ghanaian folk medicine for management of inflammatory conditions. This study was conducted to investigate the in vivo anti-inflammatory activity of the bark extract using models of acute inflammation in male Sprague Dawley rats, C57BL/6 mice and 36 ICR mice. Methods: A 70 % hydro-ethanol extract of the stem bark (HFE) was evaluated at doses of 5–500 mg/kg bw. Local anaphylaxis was modelled by the pinnal cutaneous anaphylactic test. Systemic anaphylaxis or sepsis were modeled by compound 48/80 or lipopolysaccharide, respectively. Clonidine-induced catalepsy was used to investigate effect on histamine signaling. Anti-oedematogenic effect was assessed by induction with carrageenan. Effects on mediators of biphasic acute inflammation were studied using histamine and serotonin (early phase) or prostaglandin E2 (late phase).Results: HFE demonstrated anti-inflammatory and/or anti-oedematogenic activity comparable to standard doses of aspirin and diclofenac (inhibitors of cyclooxygenases-1 and -2), chlorpheniramine (histamine H1-receptor antagonist), dexamethasone (glucocorticoid receptor agonist), granisetron (serotonin receptor antagonist) and sodium cromoglycate (inhibitor of mast cell degranulation). All observed HFE bioactivities increased with dose.Conclusions: The data provide evidence that the extract of H. floribunda stem bark has anti-anaphylactic and anti-oedematogenic effects; by interfering with signalling or metabolism of histamine, serotonin and prostaglandin E2 which mediate progression of inflammation. The anti-inflammatory and antihistaminic activities of HFE may be relevant in the context of management of COVID-19.

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“…The number of ECL cells found in the gastric body in our study using anti-HDC IHC was lower than the numbers of D cells found in the control group and in the PPI group, with or without HP infection. The HDC enzyme converts histidine into histamine 9 , 12 , 13 . HDC is also expressed in mastocytes and basophils, wherein histamine is stored in granules 12 , these are cells with different morphological characteristics than ECL cells.…”

Section: Discussionmentioning

confidence: 99%

“…The HDC enzyme converts histidine into histamine 9 , 12 , 13 . HDC is also expressed in mastocytes and basophils, wherein histamine is stored in granules 12 , these are cells with different morphological characteristics than ECL cells.…”

Section: Discussionmentioning

confidence: 99%

Chronic Use of Proton Pump Inhibitors and the Quantity of G, D, and Ecl Cells in the Stomach

Camilo

Almeida

Sousa

et al. 2020

ABCD, arq. bras. cir. dig.

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Background: Acid inhibition from chronic proton pump inhibitor use and a possible increase in gastrin can lead to changes in the regulation of hydrochloric acid production. However, it has not known whether such chronic use changes the presence of gastrin, delta, and enterochromaffin-like cells in the stomach or the relationship between gastrin and delta cells. Aim: To analyze the number of gastrin-producing gastrin cells, somatostatin-producing cells, and histamine-producing cells in patients who were chronic users of proton pump inhibitor, with or without related Helicobacter pylori infection. Methods: Biopsies from 105 patients, including 81 chronic proton pump inhibitor users (experimental group) and 24 controls, were processed immunohistochemically and subjected to counting of gastrin, delta, and enterochromaffin-like cells in high-magnification microscopic fields and in 10 glands. Results: Gastrin cell, delta cell, and enterochromaffin-like cells counts were similar across the groups and appeared to be unaffected by Helicobacter pylori infection. The ratio between gastrin cells and delta cells was higher in the chronic users of proton pump inhibitor group than in controls. Conclusion: Chronic users of proton pump inhibitor does not affect gastrin cell, delta cell, and enterochromaffin-like cell counts significantly, but may alter the ratio between gastrin cells and delta cells.

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Expression of Histidine Decarboxylase and Its Roles in Inflammation

Cited by 58 publications

References 85 publications

Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling

Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling

Hydro ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation

Chronic Use of Proton Pump Inhibitors and the Quantity of G, D, and Ecl Cells in the Stomach

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