Nickel-induced oxidative stress and effect of antioxidants in human lymphocytes

Chen, Chang-Yu; Wang, Yifen; Lin, Yan-Ting; Yen, Shu-Fang

doi:10.1007/s00204-002-0427-6

Cited by 87 publications

(50 citation statements)

References 24 publications

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“…It has been reported that administration of nickel resulted in the accumulation of iron, which in turn generate ROS via Haber-Weiss and Fenton's reaction [35,46]. The significant decrease in reduced glutathione in nickel treated group was correspondingly with previous reports [47,48]. The results showed also that nickel administration induced a significant decrease SOD, CAT and GSH-Px activities.…”

Section: Discussionsupporting

confidence: 78%

Effect of Silymarin Extracted From Silybum Marianum on Nickel Hematotoxicity and Nephrotoxicity in Male Albino Wistar Rats

Bouhalit

Kechrid

Elfeki

2017

Int J Pharm Pharm Sci

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Objective: The objective of this study was to investigate the effect of silymarin extract from Silybum marianum against nickel-induced alterations in haematological indices, kidney dysfunction and renal antioxidant defence system. Methods:Male albino Wistar rats were divided into four groups seven each. Control, silymarin, nickel and nickel plus silymarin. Silymarin was administrated orally (100 mg/kg b. wt) and nickel as nickel sulfate (NiSO4 6H2 Results:The treatment with nickel led to a significant decrease in body weight with an increase in both absolute and relative kidney weights and a significant increase in renal markers, which confirmed by histopathological alteration. A microcytic anemia was also observed, which was manifested by a reduction of red blood cells count (RBC), hemoglobin (Hb) concentration, platelet counts (Plt), hematocrit and white blood cells counts (WBC). The level of lipid peroxidation was increased. Whereas, GSH concentration and enzymatic antioxidants SOD, GSH-Px and CAT activities were decreased. The co-treatment with methanolic extract of milk thistle attenuated the variation in the hematological and renal markers, decreasing renal lipid peroxidation (p<0.05) with a concomitant increasing reduced glutathione content (p<0.01) and restoring the antioxidant enzymes (SOD, CAT, GSH-Px) in kidney, as well as an improvement in histological changes compared to those previously noticed in nickel group. 0) was given intraperitoneally (20 mg/kg b. wt) at alternative days. The experiment continued for three consecutive weeks. Body weight was recorded regularly. After overnight fasting, animals were killed and serum creatinine, serum urea, serum uric acid, hematological parameters and renal antioxidant markers were determined. Conclusion:To conclude, these findings demonstrated that silymarin extract effectively improved heamatotoxicity and nephrotoxicity caused by nickel.

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Section: Discussionsupporting

confidence: 78%

Effect of Silymarin Extracted From Silybum Marianum on Nickel Hematotoxicity and Nephrotoxicity in Male Albino Wistar Rats

Bouhalit

Kechrid

Elfeki

2017

Int J Pharm Pharm Sci

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“…NiCl 2 -induced human lymphocyte toxicity may be mediated by oxygen radical intermediates [15]. Our previous studies have also shown that dietary NiCl 2 causes intestinal and splenic oxidative damage [12] [16].…”

mentioning

confidence: 91%

Effects of Nickel Chloride on Histopathological Lesions and Oxidative Damage in the Thymus

Tang¹,

Li²,

Yin³

et al. 2014

Health

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The purpose of this study was to observe the histopathological lesions and oxidative damage induced by dietary nickel chloride (NiCl 2 ) in the thymus. A total of 280 one-day-old avian broilers were divided into four groups and fed on a corn-soybean basal diet as the control diet or the same basal diet supplemented with 300, 600, and 900 mg/kg of NiCl 2 for 42 days. In the NiCl 2 -treated groups, the broiler weight and thymic relative weight were significantly (P < 0.05 or P < 0.01) decreased. Histopathologically, thymic corpuscles were increased and enlarged; the reticular cells were degenerate and necrotic, and lymphocytes were slightly decreased and loosely arranged in the medulla of thymus in the 600 mg/kg and 900 mg/kg groups. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and the ability to inhibit hydroxy radical and glutathione (GSH) content were significantly (P < 0.05 or P < 0.01) lower in the NiCl2-treated groups than those in the control group, while MDA content was higher. The abovementioned results demonstrated that dietary NiCl 2 in excess of 300 mg/kg could reduce the broiler weight and thymic relative weight, and cause histopathological lesions and oxidative damage in the thymus, which finally impaired the thymic function.

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“…Symptoms of Ni toxicity (e.g., reduced photosynthesis and respiration rate, lower germination of seeds and decrease in root biomass) are observed at 0.19-0.85 lmol kg -1 . Nickel toxicity is also accompanied by impaired nutrient uptake, metabolism, and gas exchanges in plants (Molas, 1997;Chen and Lin, 2003;Duman andOturk, 2009). Song-Tao et al (2010) showed that Ni at 100, 200, 400, and 800 lM levels resulted in significant decrease of plant root and shoot fresh weight.…”

Section: Introductionmentioning

confidence: 98%

Stimulating and toxicity effects of nickel on growth, yield, and fruit quality of cucumber supplied with different nitrogen sources

Khoshgoftarmanesh

Bahmanziari

2012

Z. Pflanzenernähr. Bodenk.

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Limited information is available on biological effects of various levels of nickel (Ni) (deficiency to toxicity levels) on growth and yield of certain crops, particularly vegetables. In this sand-culture study, we investigated the effects of four levels of Ni (0, 50, 100, and 200 lM) on growth, yield, and fruit-quality attributes of two cucumber cultivars (Cucumis sativus L. cvs. Super Dominus and Negin) supplied with urea or NH 4 NO 3 as nitrogen source. Addition of 50 lM Ni to the nutrient solution resulted in a significant increase of shoot and root dry-matter yield of cv. Negin although this increase was greater in the urea-fed plants than those fed with NH 4 NO 3 . In both cultivars, addition of 50 lM Ni increased urease activity and thereby decreased the urea concentration in the urea treatment. Addition of 100 and 200 lM Ni caused a significant decrease in root and shoot growth of cucumber although this decrease was insignificant for cv. Super Dominus in the 100 lM treatment. The highest fruit yield, total soluble solids (TSS), and fruit firmness were achieved at the 50 lM Ni treatment. Regardless of nitrogen source, Ni addition proportional to the concentration used increased leaf Ni concentration and fruit acid ascorbic concentration. The concentration of Ni required for optimum growth and yield of cucumber varied with cultivars. The level of 50 lM was sufficient for optimum growth of cv. Negin in nutrient-solution culture while lower concentration of Ni was required for cv. Super Dominus. While the beneficial effects of sufficient levels of Ni on growth and yield of urea-fed plants was greater than with NH 4 NO 3 -fed plants, the toxic effects of Ni in these plants were also greater.

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Nickel-induced oxidative stress and effect of antioxidants in human lymphocytes

Cited by 87 publications

References 24 publications

Effect of Silymarin Extracted From Silybum Marianum on Nickel Hematotoxicity and Nephrotoxicity in Male Albino Wistar Rats

Effect of Silymarin Extracted From Silybum Marianum on Nickel Hematotoxicity and Nephrotoxicity in Male Albino Wistar Rats

Effects of Nickel Chloride on Histopathological Lesions and Oxidative Damage in the Thymus

Stimulating and toxicity effects of nickel on growth, yield, and fruit quality of cucumber supplied with different nitrogen sources

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